Expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the European eel (Anguilla anguilla) and tilapia (Oreochromis mossambicus)
Myo‐inositol is a major osmolyte, which plays an important role in cyto‐protection in many organisms exposed to a variety of environmental stresses. Myo‐inositol monophosphatase (IMPA) de‐phosphorylates any myo‐inositol 1‐phosphate recycled from the membrane phospholipid pool or synthesised de novo...
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crwiley:10.1096/fasebj.26.1_supplement.881.11 2024-06-02T07:55:12+00:00 Expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the European eel (Anguilla anguilla) and tilapia (Oreochromis mossambicus) Kalujnaia, Svetlana Gellatly, Steven Cramb, Gordon 2012 http://dx.doi.org/10.1096/fasebj.26.1_supplement.881.11 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The FASEB Journal volume 26, issue S1 ISSN 0892-6638 1530-6860 journal-article 2012 crwiley https://doi.org/10.1096/fasebj.26.1_supplement.881.11 2024-05-03T11:08:49Z Myo‐inositol is a major osmolyte, which plays an important role in cyto‐protection in many organisms exposed to a variety of environmental stresses. Myo‐inositol monophosphatase (IMPA) de‐phosphorylates any myo‐inositol 1‐phosphate recycled from the membrane phospholipid pool or synthesised de novo from glucose‐6 phosphate to generate myo‐inositol. Studies have identified changes in expression of a number of Impa isoforms when euryhaline fish move between freshwater (FW) and seawater (SW), however these changes in gene expression are isoform‐ and species‐specific. The Impa1 isoform is primarily expressed in epithelial tissues exposed to the aquatic environment. In eels and tilapia, Impa1 expression was located throughout the basal/germinal cell layers within the stratified epithelia of the oesophagus, skin, fin and epithelia of the branchial arch and primary filaments, the interstitial cells and/or glomerulae between renal tubules and, specifically in eels, also in branchial and ray fin chondrocytes. In all tissues examined from eels and tilapia, Impa1 expression and inositol contents were markedly up‐regulated after transfer of fish to SW. These results suggest that increased inositol concentrations promotes renal water retention and maintains the cell volume of epithelial and epidermal tissues when fish are exposed to the dehydrating effects of the SW environment. Article in Journal/Newspaper Anguilla anguilla European eel Wiley Online Library The FASEB Journal 26 S1 |
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Wiley Online Library |
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language |
English |
description |
Myo‐inositol is a major osmolyte, which plays an important role in cyto‐protection in many organisms exposed to a variety of environmental stresses. Myo‐inositol monophosphatase (IMPA) de‐phosphorylates any myo‐inositol 1‐phosphate recycled from the membrane phospholipid pool or synthesised de novo from glucose‐6 phosphate to generate myo‐inositol. Studies have identified changes in expression of a number of Impa isoforms when euryhaline fish move between freshwater (FW) and seawater (SW), however these changes in gene expression are isoform‐ and species‐specific. The Impa1 isoform is primarily expressed in epithelial tissues exposed to the aquatic environment. In eels and tilapia, Impa1 expression was located throughout the basal/germinal cell layers within the stratified epithelia of the oesophagus, skin, fin and epithelia of the branchial arch and primary filaments, the interstitial cells and/or glomerulae between renal tubules and, specifically in eels, also in branchial and ray fin chondrocytes. In all tissues examined from eels and tilapia, Impa1 expression and inositol contents were markedly up‐regulated after transfer of fish to SW. These results suggest that increased inositol concentrations promotes renal water retention and maintains the cell volume of epithelial and epidermal tissues when fish are exposed to the dehydrating effects of the SW environment. |
format |
Article in Journal/Newspaper |
author |
Kalujnaia, Svetlana Gellatly, Steven Cramb, Gordon |
spellingShingle |
Kalujnaia, Svetlana Gellatly, Steven Cramb, Gordon Expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the European eel (Anguilla anguilla) and tilapia (Oreochromis mossambicus) |
author_facet |
Kalujnaia, Svetlana Gellatly, Steven Cramb, Gordon |
author_sort |
Kalujnaia, Svetlana |
title |
Expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the European eel (Anguilla anguilla) and tilapia (Oreochromis mossambicus) |
title_short |
Expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the European eel (Anguilla anguilla) and tilapia (Oreochromis mossambicus) |
title_full |
Expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the European eel (Anguilla anguilla) and tilapia (Oreochromis mossambicus) |
title_fullStr |
Expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the European eel (Anguilla anguilla) and tilapia (Oreochromis mossambicus) |
title_full_unstemmed |
Expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the European eel (Anguilla anguilla) and tilapia (Oreochromis mossambicus) |
title_sort |
expression and functions of inositol monophosphatase in seawater adapted euryhaline teleosts such as the european eel (anguilla anguilla) and tilapia (oreochromis mossambicus) |
publisher |
Wiley |
publishDate |
2012 |
url |
http://dx.doi.org/10.1096/fasebj.26.1_supplement.881.11 |
genre |
Anguilla anguilla European eel |
genre_facet |
Anguilla anguilla European eel |
op_source |
The FASEB Journal volume 26, issue S1 ISSN 0892-6638 1530-6860 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1096/fasebj.26.1_supplement.881.11 |
container_title |
The FASEB Journal |
container_volume |
26 |
container_issue |
S1 |
_version_ |
1800746797351567360 |