The carbon isotope ratio of RBC alanine is a biomarker of sugar‐sweetened beverage (SSB) intake
We are developing biomarkers of sugar‐sweetened beverage (SSB) intake for application in a Yup'ik Eskimo population, to detect associations with chronic disease risk. The naturally‐occurring carbon isotope ratio of human serum and RBC has been proposed as a biomarker of SSB intake, based on the...
Published in: | The FASEB Journal |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2012
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1096/fasebj.26.1_supplement.131.2 |
id |
crwiley:10.1096/fasebj.26.1_supplement.131.2 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1096/fasebj.26.1_supplement.131.2 2024-06-02T08:06:11+00:00 The carbon isotope ratio of RBC alanine is a biomarker of sugar‐sweetened beverage (SSB) intake OˈBrien, Diane Marie Choy, Kyungcheol Nash, Sarah 2012 http://dx.doi.org/10.1096/fasebj.26.1_supplement.131.2 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The FASEB Journal volume 26, issue S1 ISSN 0892-6638 1530-6860 journal-article 2012 crwiley https://doi.org/10.1096/fasebj.26.1_supplement.131.2 2024-05-03T11:33:37Z We are developing biomarkers of sugar‐sweetened beverage (SSB) intake for application in a Yup'ik Eskimo population, to detect associations with chronic disease risk. The naturally‐occurring carbon isotope ratio of human serum and RBC has been proposed as a biomarker of SSB intake, based on the elevated carbon isotope ratio of corn syrup and cane sugar. However, the marker's utility is diminished by a concurrent relationship with meat from corn‐fed animals. Here we evaluated the association of SSB intake and the carbon isotope ratio of individual amino acids in RBC, to investigate whether one might provide a biomarker that was more specific to SSB intake. The carbon isotope ratio of alanine was strongly (r = 0.70) associated with SSB intake but not associated with intake of corn‐fed market meat. Alanine can be readily synthesized in cells from pyruvate, which derives from glucose. We suggest that this synthetic pathway allows the capture of carbon from dietary sugars in tissue proteins, such as RBC, providing a stable biomarker of intake. This study was funded by a Center of Biomedical Research Excellence grant from the NIH NCRR (P20 RR16430‐10) and NIH NIDDK R01DK07442 Article in Journal/Newspaper eskimo* Yup'ik Wiley Online Library The FASEB Journal 26 S1 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
We are developing biomarkers of sugar‐sweetened beverage (SSB) intake for application in a Yup'ik Eskimo population, to detect associations with chronic disease risk. The naturally‐occurring carbon isotope ratio of human serum and RBC has been proposed as a biomarker of SSB intake, based on the elevated carbon isotope ratio of corn syrup and cane sugar. However, the marker's utility is diminished by a concurrent relationship with meat from corn‐fed animals. Here we evaluated the association of SSB intake and the carbon isotope ratio of individual amino acids in RBC, to investigate whether one might provide a biomarker that was more specific to SSB intake. The carbon isotope ratio of alanine was strongly (r = 0.70) associated with SSB intake but not associated with intake of corn‐fed market meat. Alanine can be readily synthesized in cells from pyruvate, which derives from glucose. We suggest that this synthetic pathway allows the capture of carbon from dietary sugars in tissue proteins, such as RBC, providing a stable biomarker of intake. This study was funded by a Center of Biomedical Research Excellence grant from the NIH NCRR (P20 RR16430‐10) and NIH NIDDK R01DK07442 |
format |
Article in Journal/Newspaper |
author |
OˈBrien, Diane Marie Choy, Kyungcheol Nash, Sarah |
spellingShingle |
OˈBrien, Diane Marie Choy, Kyungcheol Nash, Sarah The carbon isotope ratio of RBC alanine is a biomarker of sugar‐sweetened beverage (SSB) intake |
author_facet |
OˈBrien, Diane Marie Choy, Kyungcheol Nash, Sarah |
author_sort |
OˈBrien, Diane Marie |
title |
The carbon isotope ratio of RBC alanine is a biomarker of sugar‐sweetened beverage (SSB) intake |
title_short |
The carbon isotope ratio of RBC alanine is a biomarker of sugar‐sweetened beverage (SSB) intake |
title_full |
The carbon isotope ratio of RBC alanine is a biomarker of sugar‐sweetened beverage (SSB) intake |
title_fullStr |
The carbon isotope ratio of RBC alanine is a biomarker of sugar‐sweetened beverage (SSB) intake |
title_full_unstemmed |
The carbon isotope ratio of RBC alanine is a biomarker of sugar‐sweetened beverage (SSB) intake |
title_sort |
carbon isotope ratio of rbc alanine is a biomarker of sugar‐sweetened beverage (ssb) intake |
publisher |
Wiley |
publishDate |
2012 |
url |
http://dx.doi.org/10.1096/fasebj.26.1_supplement.131.2 |
genre |
eskimo* Yup'ik |
genre_facet |
eskimo* Yup'ik |
op_source |
The FASEB Journal volume 26, issue S1 ISSN 0892-6638 1530-6860 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1096/fasebj.26.1_supplement.131.2 |
container_title |
The FASEB Journal |
container_volume |
26 |
container_issue |
S1 |
_version_ |
1800751081872949248 |