Postprandial changes in GI‐tract peptide hormones in the teleost Atlantic salmon
The spatial distribution of two isoforms of Ghrelin (Ghrelin‐1 and ‐2), two isoforms of Cholecystokinin (CCK‐L and ‐N) and peptide YY (PYY) was assessed by Q‐PCR in four GI‐tract segments covering stomach, pyloric caeca, midgut and hindgut after feeding a single meal to Atlantic salmon. Both CCK‐L a...
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crwiley:10.1096/fasebj.24.1_supplement.lb620 2024-06-02T08:03:33+00:00 Postprandial changes in GI‐tract peptide hormones in the teleost Atlantic salmon Ronnestad, Ivar Valen, Ragnhild Murashita, Koji Jordal, Ann‐Elise Olderbakk 2010 http://dx.doi.org/10.1096/fasebj.24.1_supplement.lb620 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The FASEB Journal volume 24, issue S1 ISSN 0892-6638 1530-6860 journal-article 2010 crwiley https://doi.org/10.1096/fasebj.24.1_supplement.lb620 2024-05-03T11:37:31Z The spatial distribution of two isoforms of Ghrelin (Ghrelin‐1 and ‐2), two isoforms of Cholecystokinin (CCK‐L and ‐N) and peptide YY (PYY) was assessed by Q‐PCR in four GI‐tract segments covering stomach, pyloric caeca, midgut and hindgut after feeding a single meal to Atlantic salmon. Both CCK‐L and CCK‐N levels increased within 1.5 hours past feeding (hpf). At this time the stomach was still ca 80% full (the gastric evacuation half‐time was 4.5 hrs), the gallbladder was almost completely empty and chyme had started to be transferred into the midgut. During the 24 hpf there were both temporal and spatial differences between the expression profile of the CCK isoforms. PYY expression increased at 1.5 hpf, and then decreased after 3 hpf. Feeding had only minor effects on the Ghrelin isoforms expression. Taken together this suggests that CCK and PYY have in part similar roles in regulating digestive processes to that observed in higher vertebrates. The two isoforms of CCK appear to have different functions. The data did not identify a role for Ghrelin related to digestion or appetite comparable to the orexigenic role described in humans. Article in Journal/Newspaper Atlantic salmon Wiley Online Library The FASEB Journal 24 S1 |
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Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
The spatial distribution of two isoforms of Ghrelin (Ghrelin‐1 and ‐2), two isoforms of Cholecystokinin (CCK‐L and ‐N) and peptide YY (PYY) was assessed by Q‐PCR in four GI‐tract segments covering stomach, pyloric caeca, midgut and hindgut after feeding a single meal to Atlantic salmon. Both CCK‐L and CCK‐N levels increased within 1.5 hours past feeding (hpf). At this time the stomach was still ca 80% full (the gastric evacuation half‐time was 4.5 hrs), the gallbladder was almost completely empty and chyme had started to be transferred into the midgut. During the 24 hpf there were both temporal and spatial differences between the expression profile of the CCK isoforms. PYY expression increased at 1.5 hpf, and then decreased after 3 hpf. Feeding had only minor effects on the Ghrelin isoforms expression. Taken together this suggests that CCK and PYY have in part similar roles in regulating digestive processes to that observed in higher vertebrates. The two isoforms of CCK appear to have different functions. The data did not identify a role for Ghrelin related to digestion or appetite comparable to the orexigenic role described in humans. |
format |
Article in Journal/Newspaper |
author |
Ronnestad, Ivar Valen, Ragnhild Murashita, Koji Jordal, Ann‐Elise Olderbakk |
spellingShingle |
Ronnestad, Ivar Valen, Ragnhild Murashita, Koji Jordal, Ann‐Elise Olderbakk Postprandial changes in GI‐tract peptide hormones in the teleost Atlantic salmon |
author_facet |
Ronnestad, Ivar Valen, Ragnhild Murashita, Koji Jordal, Ann‐Elise Olderbakk |
author_sort |
Ronnestad, Ivar |
title |
Postprandial changes in GI‐tract peptide hormones in the teleost Atlantic salmon |
title_short |
Postprandial changes in GI‐tract peptide hormones in the teleost Atlantic salmon |
title_full |
Postprandial changes in GI‐tract peptide hormones in the teleost Atlantic salmon |
title_fullStr |
Postprandial changes in GI‐tract peptide hormones in the teleost Atlantic salmon |
title_full_unstemmed |
Postprandial changes in GI‐tract peptide hormones in the teleost Atlantic salmon |
title_sort |
postprandial changes in gi‐tract peptide hormones in the teleost atlantic salmon |
publisher |
Wiley |
publishDate |
2010 |
url |
http://dx.doi.org/10.1096/fasebj.24.1_supplement.lb620 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
The FASEB Journal volume 24, issue S1 ISSN 0892-6638 1530-6860 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1096/fasebj.24.1_supplement.lb620 |
container_title |
The FASEB Journal |
container_volume |
24 |
container_issue |
S1 |
_version_ |
1800748106739875840 |