Enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals
The objective of this study was to examine the metabolic plasticity of skeletal and cardiac muscle when exposed to varying temperatures. When faced with extreme temperature variation, activities of metabolic enzymes in homeothermic terrestrial mammals are directly correlated with temperature. We inv...
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crwiley:10.1096/fasebj.22.1_supplement.757.27 2024-06-02T08:07:46+00:00 Enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals Pearson, Linnea E. Gullett, Keyona C. Florant, Gregory L. Kanatous, Shane B. 2008 http://dx.doi.org/10.1096/fasebj.22.1_supplement.757.27 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor The FASEB Journal volume 22, issue S1 ISSN 0892-6638 1530-6860 journal-article 2008 crwiley https://doi.org/10.1096/fasebj.22.1_supplement.757.27 2024-05-03T11:41:34Z The objective of this study was to examine the metabolic plasticity of skeletal and cardiac muscle when exposed to varying temperatures. When faced with extreme temperature variation, activities of metabolic enzymes in homeothermic terrestrial mammals are directly correlated with temperature. We investigated the physiological adaptations in two extreme mammalian conditions; a diving mammal, a homeotherm, able to maintain function at low temperature and a hibernator, a heterotherm that decreases activity in response to a decrease in temperature. We measured the enzyme activity of citrate synthase, lactate dehydrogenase and catalase at 10, 25, 37 and 40°C in cardiac and skeletal muscle of the golden mantle ground squirrel (hibernator), harbor seal (diving mammal) and rat (terrestrial mammal). Surprisingly, our results indicate there is no direct correlation between temperature and enzymatic activity in the homeothermic diving mammal. In addition, the enzyme activity of the diving mammal showed a similar pattern of activity in response to temperature variation as the ground squirrel. And as expected, due to its smaller size, the ground squirrel had greater overall enzyme activity. Our results suggest there are similar adaptations in the cardiac and skeletal muscles of diving and hibernating mammals under varying temperatures that preserve enzyme function even at low environmental temperatures. Article in Journal/Newspaper harbor seal Wiley Online Library The FASEB Journal 22 S1 |
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English |
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The objective of this study was to examine the metabolic plasticity of skeletal and cardiac muscle when exposed to varying temperatures. When faced with extreme temperature variation, activities of metabolic enzymes in homeothermic terrestrial mammals are directly correlated with temperature. We investigated the physiological adaptations in two extreme mammalian conditions; a diving mammal, a homeotherm, able to maintain function at low temperature and a hibernator, a heterotherm that decreases activity in response to a decrease in temperature. We measured the enzyme activity of citrate synthase, lactate dehydrogenase and catalase at 10, 25, 37 and 40°C in cardiac and skeletal muscle of the golden mantle ground squirrel (hibernator), harbor seal (diving mammal) and rat (terrestrial mammal). Surprisingly, our results indicate there is no direct correlation between temperature and enzymatic activity in the homeothermic diving mammal. In addition, the enzyme activity of the diving mammal showed a similar pattern of activity in response to temperature variation as the ground squirrel. And as expected, due to its smaller size, the ground squirrel had greater overall enzyme activity. Our results suggest there are similar adaptations in the cardiac and skeletal muscles of diving and hibernating mammals under varying temperatures that preserve enzyme function even at low environmental temperatures. |
format |
Article in Journal/Newspaper |
author |
Pearson, Linnea E. Gullett, Keyona C. Florant, Gregory L. Kanatous, Shane B. |
spellingShingle |
Pearson, Linnea E. Gullett, Keyona C. Florant, Gregory L. Kanatous, Shane B. Enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals |
author_facet |
Pearson, Linnea E. Gullett, Keyona C. Florant, Gregory L. Kanatous, Shane B. |
author_sort |
Pearson, Linnea E. |
title |
Enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals |
title_short |
Enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals |
title_full |
Enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals |
title_fullStr |
Enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals |
title_full_unstemmed |
Enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals |
title_sort |
enzyme activities in mammals adapted to extreme environments: hibernators and divers versus terrestrial mammals |
publisher |
Wiley |
publishDate |
2008 |
url |
http://dx.doi.org/10.1096/fasebj.22.1_supplement.757.27 |
genre |
harbor seal |
genre_facet |
harbor seal |
op_source |
The FASEB Journal volume 22, issue S1 ISSN 0892-6638 1530-6860 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1096/fasebj.22.1_supplement.757.27 |
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The FASEB Journal |
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22 |
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S1 |
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1800752892266676224 |