Intraperitoneal myriocin upregulates transforming growth factor b1 (tgf‐b1) expression in murine destabilization of the medial meniscus model of osteoarthritis—evidence for a role of ceramide species in cartilage homeostasis

Ceramides are biologically active sphingolipids known to play a role in numerous physiological and pathological processes. In particular, ceramides are known mediators in insulin resistance, and are found in increased abundance in osteoarthritic synovial fluid. Given the comorbidity between osteoart...

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Bibliographic Details
Published in:The FASEB Journal
Main Authors: Rose, Brandon J, Goodman, Michael A, Kooyman, David L
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2018
Subjects:
Online Access:http://dx.doi.org/10.1096/fasebj.2018.32.1_supplement.lb579