Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)
Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune‐stimulating and antiallergic activity as well....
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crwiley:10.1093/ecam/nen072 2024-09-15T17:46:33+00:00 Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. 2011 http://dx.doi.org/10.1093/ecam/nen072 http://downloads.hindawi.com/journals/ecam/2011/738131.pdf http://downloads.hindawi.com/journals/ecam/2011/738131.xml https://onlinelibrary.wiley.com/doi/pdf/10.1093/ecam/nen072 en eng Wiley http://creativecommons.org/licenses/by/3.0/ Evidence-Based Complementary and Alternative Medicine volume 2011, issue 1 ISSN 1741-427X 1741-4288 journal-article 2011 crwiley https://doi.org/10.1093/ecam/nen072 2024-07-23T04:15:20Z Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune‐stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(‐related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea . Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis‐inducing amyloid peptide fragment β ‐fragment 25–35 (A β 25–35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth‐promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives. Article in Journal/Newspaper Antarc* Antarctica Snow Petrels Wiley Online Library Evidence-Based Complementary and Alternative Medicine 2011 1 |
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Wiley Online Library |
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language |
English |
description |
Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune‐stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(‐related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea . Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis‐inducing amyloid peptide fragment β ‐fragment 25–35 (A β 25–35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth‐promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives. |
format |
Article in Journal/Newspaper |
author |
Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. |
spellingShingle |
Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
author_facet |
Aiello, Anna Fattorusso, Ernesto Menna, Marialuisa Vitalone, Rocco Schröder, Heinz C. Müller, Werner E. G. |
author_sort |
Aiello, Anna |
title |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_short |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_full |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_fullStr |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_full_unstemmed |
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity) |
title_sort |
mumijo traditional medicine: fossil deposits from antarctica (chemical composition and beneficial bioactivity) |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1093/ecam/nen072 http://downloads.hindawi.com/journals/ecam/2011/738131.pdf http://downloads.hindawi.com/journals/ecam/2011/738131.xml https://onlinelibrary.wiley.com/doi/pdf/10.1093/ecam/nen072 |
genre |
Antarc* Antarctica Snow Petrels |
genre_facet |
Antarc* Antarctica Snow Petrels |
op_source |
Evidence-Based Complementary and Alternative Medicine volume 2011, issue 1 ISSN 1741-427X 1741-4288 |
op_rights |
http://creativecommons.org/licenses/by/3.0/ |
op_doi |
https://doi.org/10.1093/ecam/nen072 |
container_title |
Evidence-Based Complementary and Alternative Medicine |
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2011 |
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1 |
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1810494790344638464 |