Residue Depletion of Tritium‐Labeled Ivermectin in the Muscle Tissues of Aquacultured Atlantic Salmon, Tilapia, and Catfish following Oral Treatment
Abstract The residue depletion and metabolism profiles of tritium‐labeled ivermectin in the muscle tissues of aquacultured Atlantic salmon Salmo salar , hybrid tilapia (Nile tilapia Oreochromis niloticus × Mozambique tilapia O. mossambicus hereafter, “tilapia”) and channel catfish Ictalurus punctatu...
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Online Access: | http://dx.doi.org/10.1080/15222055.2011.638417 https://afspubs.onlinelibrary.wiley.com/doi/pdf/10.1080/15222055.2011.638417 |
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crwiley:10.1080/15222055.2011.638417 2024-06-02T08:03:26+00:00 Residue Depletion of Tritium‐Labeled Ivermectin in the Muscle Tissues of Aquacultured Atlantic Salmon, Tilapia, and Catfish following Oral Treatment Shaikh, Badar Rummel, Nathan Gieseker, Charles Cheely, Christie‐Sue Reimschuessel, Renate 2012 http://dx.doi.org/10.1080/15222055.2011.638417 https://afspubs.onlinelibrary.wiley.com/doi/pdf/10.1080/15222055.2011.638417 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor North American Journal of Aquaculture volume 74, issue 1, page 27-33 ISSN 1522-2055 1548-8454 journal-article 2012 crwiley https://doi.org/10.1080/15222055.2011.638417 2024-05-03T11:19:26Z Abstract The residue depletion and metabolism profiles of tritium‐labeled ivermectin in the muscle tissues of aquacultured Atlantic salmon Salmo salar , hybrid tilapia (Nile tilapia Oreochromis niloticus × Mozambique tilapia O. mossambicus hereafter, “tilapia”) and channel catfish Ictalurus punctatus following oral treatment are reported. Fish were administered 3 H‐ivermectin at the dose level of 0.1 mg/kg of body weight (9–10 μ curies [Ci]) in a gel capsule via a stomach tube. At each postdose withdrawal time (1, 7, 14, 21, and 28 d), six fish of each species were sedated, euthanized, bled, and scaled, and fillets with adhering skin (except for catfish) were collected. The muscle fillets were homogenized in dry ice and an aliquot of each was extracted in acetonitrile followed by a high‐performance liquid chromatographic analysis to determine the presence of parent ivermectin and its potential metabolites. The analysis of the muscle extracts revealed that the parent 3 H‐ivermectin is the major residue present for the three fish species studied. The results showed that the highest radioactive residue concentrations (ivermectin equivalents) of 21 and 6 ng/g were obtained on postdose day 1 for channel catfish and tilapia, respectively. For Atlantic salmon, the highest concentration of 14 ng/g was detected on day 7. By postdose day 21, the ivermectin radioactive residue depleted to less than 10 ng/g for all three species. No significant radioactive residue concentrations of metabolites were detected on any of the sampling days. These results suggest that parent ivermectin could serve as a marker residue to monitor its unauthorized use in Atlantic salmon, tilapia, and channel catfish. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library North American Journal of Aquaculture 74 1 27 33 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract The residue depletion and metabolism profiles of tritium‐labeled ivermectin in the muscle tissues of aquacultured Atlantic salmon Salmo salar , hybrid tilapia (Nile tilapia Oreochromis niloticus × Mozambique tilapia O. mossambicus hereafter, “tilapia”) and channel catfish Ictalurus punctatus following oral treatment are reported. Fish were administered 3 H‐ivermectin at the dose level of 0.1 mg/kg of body weight (9–10 μ curies [Ci]) in a gel capsule via a stomach tube. At each postdose withdrawal time (1, 7, 14, 21, and 28 d), six fish of each species were sedated, euthanized, bled, and scaled, and fillets with adhering skin (except for catfish) were collected. The muscle fillets were homogenized in dry ice and an aliquot of each was extracted in acetonitrile followed by a high‐performance liquid chromatographic analysis to determine the presence of parent ivermectin and its potential metabolites. The analysis of the muscle extracts revealed that the parent 3 H‐ivermectin is the major residue present for the three fish species studied. The results showed that the highest radioactive residue concentrations (ivermectin equivalents) of 21 and 6 ng/g were obtained on postdose day 1 for channel catfish and tilapia, respectively. For Atlantic salmon, the highest concentration of 14 ng/g was detected on day 7. By postdose day 21, the ivermectin radioactive residue depleted to less than 10 ng/g for all three species. No significant radioactive residue concentrations of metabolites were detected on any of the sampling days. These results suggest that parent ivermectin could serve as a marker residue to monitor its unauthorized use in Atlantic salmon, tilapia, and channel catfish. |
format |
Article in Journal/Newspaper |
author |
Shaikh, Badar Rummel, Nathan Gieseker, Charles Cheely, Christie‐Sue Reimschuessel, Renate |
spellingShingle |
Shaikh, Badar Rummel, Nathan Gieseker, Charles Cheely, Christie‐Sue Reimschuessel, Renate Residue Depletion of Tritium‐Labeled Ivermectin in the Muscle Tissues of Aquacultured Atlantic Salmon, Tilapia, and Catfish following Oral Treatment |
author_facet |
Shaikh, Badar Rummel, Nathan Gieseker, Charles Cheely, Christie‐Sue Reimschuessel, Renate |
author_sort |
Shaikh, Badar |
title |
Residue Depletion of Tritium‐Labeled Ivermectin in the Muscle Tissues of Aquacultured Atlantic Salmon, Tilapia, and Catfish following Oral Treatment |
title_short |
Residue Depletion of Tritium‐Labeled Ivermectin in the Muscle Tissues of Aquacultured Atlantic Salmon, Tilapia, and Catfish following Oral Treatment |
title_full |
Residue Depletion of Tritium‐Labeled Ivermectin in the Muscle Tissues of Aquacultured Atlantic Salmon, Tilapia, and Catfish following Oral Treatment |
title_fullStr |
Residue Depletion of Tritium‐Labeled Ivermectin in the Muscle Tissues of Aquacultured Atlantic Salmon, Tilapia, and Catfish following Oral Treatment |
title_full_unstemmed |
Residue Depletion of Tritium‐Labeled Ivermectin in the Muscle Tissues of Aquacultured Atlantic Salmon, Tilapia, and Catfish following Oral Treatment |
title_sort |
residue depletion of tritium‐labeled ivermectin in the muscle tissues of aquacultured atlantic salmon, tilapia, and catfish following oral treatment |
publisher |
Wiley |
publishDate |
2012 |
url |
http://dx.doi.org/10.1080/15222055.2011.638417 https://afspubs.onlinelibrary.wiley.com/doi/pdf/10.1080/15222055.2011.638417 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
North American Journal of Aquaculture volume 74, issue 1, page 27-33 ISSN 1522-2055 1548-8454 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1080/15222055.2011.638417 |
container_title |
North American Journal of Aquaculture |
container_volume |
74 |
container_issue |
1 |
container_start_page |
27 |
op_container_end_page |
33 |
_version_ |
1800747961948307456 |