Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar
Abstract: This study describes the long‐term effects of surgical ablation of the pineal gland on the spine of 3‐yr‐old Atlantic salmon ( Salmo salar L.) with a mean weight of 3.2 kg. Radiographic examinations showed that 82% of the pinealectomized fish developed marked lateral (scoliosis) and dorso‐...
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crwiley:10.1046/j.1600-079x.2003.00109.x 2024-09-15T17:56:11+00:00 Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar Fjelldal, Per Gunnar Grotmol, Sindre Kryvi, Harald Gjerdet, Nils Roar Taranger, Geir Lasse Hansen, Tom Porter, Mark J. R. Totland, Geir K. 2004 http://dx.doi.org/10.1046/j.1600-079x.2003.00109.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1600-079X.2003.00109.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1600-079X.2003.00109.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Pineal Research volume 36, issue 2, page 132-139 ISSN 0742-3098 1600-079X journal-article 2004 crwiley https://doi.org/10.1046/j.1600-079x.2003.00109.x 2024-08-27T04:32:19Z Abstract: This study describes the long‐term effects of surgical ablation of the pineal gland on the spine of 3‐yr‐old Atlantic salmon ( Salmo salar L.) with a mean weight of 3.2 kg. Radiographic examinations showed that 82% of the pinealectomized fish developed marked lateral (scoliosis) and dorso‐ventral spinal curvatures. The proportions of the individual vertebral bodies and their mechanical properties were also altered. The stiffness, yield limit and resilience of the vertebral bodies, as measured by compression in the cranio‐caudal direction, were significantly lower in the pinealectomized than in the sham‐pinealectomized group. Calcium, phosphorous and total mineral content of the vertebral bodies were also significantly lower in the pinealectomized fish, while these parameters were similar in scales in the two groups. Alterations of the spinal curve accompanied by changes in the proportions, mechanical strength and mineral content of the vertebral bodies of the pinealectomized salmon indicate that melatonin has several functions related to vertebral bone growth. As the lesions found in salmon are similar to the spinal malformations observed in avian species and mammals after pinealectomy, this study strengthens the hypothesis of a phylogenetically conserved function of the pineal gland related to skeletal development. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Journal of Pineal Research 36 2 132 139 |
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Wiley Online Library |
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English |
description |
Abstract: This study describes the long‐term effects of surgical ablation of the pineal gland on the spine of 3‐yr‐old Atlantic salmon ( Salmo salar L.) with a mean weight of 3.2 kg. Radiographic examinations showed that 82% of the pinealectomized fish developed marked lateral (scoliosis) and dorso‐ventral spinal curvatures. The proportions of the individual vertebral bodies and their mechanical properties were also altered. The stiffness, yield limit and resilience of the vertebral bodies, as measured by compression in the cranio‐caudal direction, were significantly lower in the pinealectomized than in the sham‐pinealectomized group. Calcium, phosphorous and total mineral content of the vertebral bodies were also significantly lower in the pinealectomized fish, while these parameters were similar in scales in the two groups. Alterations of the spinal curve accompanied by changes in the proportions, mechanical strength and mineral content of the vertebral bodies of the pinealectomized salmon indicate that melatonin has several functions related to vertebral bone growth. As the lesions found in salmon are similar to the spinal malformations observed in avian species and mammals after pinealectomy, this study strengthens the hypothesis of a phylogenetically conserved function of the pineal gland related to skeletal development. |
format |
Article in Journal/Newspaper |
author |
Fjelldal, Per Gunnar Grotmol, Sindre Kryvi, Harald Gjerdet, Nils Roar Taranger, Geir Lasse Hansen, Tom Porter, Mark J. R. Totland, Geir K. |
spellingShingle |
Fjelldal, Per Gunnar Grotmol, Sindre Kryvi, Harald Gjerdet, Nils Roar Taranger, Geir Lasse Hansen, Tom Porter, Mark J. R. Totland, Geir K. Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar |
author_facet |
Fjelldal, Per Gunnar Grotmol, Sindre Kryvi, Harald Gjerdet, Nils Roar Taranger, Geir Lasse Hansen, Tom Porter, Mark J. R. Totland, Geir K. |
author_sort |
Fjelldal, Per Gunnar |
title |
Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar |
title_short |
Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar |
title_full |
Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar |
title_fullStr |
Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar |
title_full_unstemmed |
Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar |
title_sort |
pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in atlantic salmon, salmo salar |
publisher |
Wiley |
publishDate |
2004 |
url |
http://dx.doi.org/10.1046/j.1600-079x.2003.00109.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1600-079X.2003.00109.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1600-079X.2003.00109.x |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Pineal Research volume 36, issue 2, page 132-139 ISSN 0742-3098 1600-079X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1600-079x.2003.00109.x |
container_title |
Journal of Pineal Research |
container_volume |
36 |
container_issue |
2 |
container_start_page |
132 |
op_container_end_page |
139 |
_version_ |
1810432398173667328 |