Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 57
BACKGROUND: Since 1991, five sets of electrophysiological criteria for CIDP have been reported. However, until now, receiver operator characteristic (ROC), such as sensitivity and specificity, of only AAN criteria were investigated, showing a high specificity, but intermediate sensitivity. The appli...
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crwiley:10.1046/j.1529-8027.2003.00057.x 2024-06-02T08:05:48+00:00 Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 57 Cocito, D Chiò, A Isoardo, G Ciaramitaro, P Ghiglione, P Poglio, F Vercellino, M Mutani, R Bergamasco, B 2003 http://dx.doi.org/10.1046/j.1529-8027.2003.00057.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1529-8027.2003.00057.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of the Peripheral Nervous System volume 8, issue 1, page 29-58 ISSN 1085-9489 1529-8027 journal-article 2003 crwiley https://doi.org/10.1046/j.1529-8027.2003.00057.x 2024-05-03T11:59:50Z BACKGROUND: Since 1991, five sets of electrophysiological criteria for CIDP have been reported. However, until now, receiver operator characteristic (ROC), such as sensitivity and specificity, of only AAN criteria were investigated, showing a high specificity, but intermediate sensitivity. The application of these criteria may be useful in clinical trials, but is inadequate in clinical practice, since they preclude immunomodulating treatment in patients who do not meet them. OBJECTIVE: 1) to evaluate the ROC and predictive value of five different electrophysiological criteria for CIDP (AAN, INCAT, Rotta et al, Nicholas et al. and Saperstein et al.); 2) to identify the most informative electrophysiological features indicative of demyelination by mean of the likelihood ratio; 3) to determine, in our series of cases, a set of minimal electrophysiological criteria (albeit aspecific) enough sensitive for CIDP diagnosis. PATIENTS AND METHODS: 20 patients with sensorimotor polyneuropathy, progressive for at least 2 months, with weakness in least two limbs and documented improvement in strength in response to immunotherapy. Other potential causes were excluded, including diabetes and IgM paraproteinemia with or without anti‐MAG reactivity. Twelve patients with axonal polyneuropathy associated with diabetes and 12 patients with amyotrophic lateral sclerosis were included as controls. Nerve conduction studies (NCS) were evaluated according to all five sets of NCS criteria and ROC was calculated. Likelihood ratio for CIDP was evaluated for each set of NCS criteria and for presence of each of the following features in different number of nerves: motor conduction velocities (MCV), conduction blocks/temporal dispersion, distal motor (DML) and F‐wave latencies (FWL). MCV, DML and FWL were considered indicative of demyelination if decreased or increased as suggested by AAN criteria. Results will be discussed. Article in Journal/Newspaper DML Wiley Online Library Journal of the Peripheral Nervous System 8 1 29 58 |
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Wiley Online Library |
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English |
description |
BACKGROUND: Since 1991, five sets of electrophysiological criteria for CIDP have been reported. However, until now, receiver operator characteristic (ROC), such as sensitivity and specificity, of only AAN criteria were investigated, showing a high specificity, but intermediate sensitivity. The application of these criteria may be useful in clinical trials, but is inadequate in clinical practice, since they preclude immunomodulating treatment in patients who do not meet them. OBJECTIVE: 1) to evaluate the ROC and predictive value of five different electrophysiological criteria for CIDP (AAN, INCAT, Rotta et al, Nicholas et al. and Saperstein et al.); 2) to identify the most informative electrophysiological features indicative of demyelination by mean of the likelihood ratio; 3) to determine, in our series of cases, a set of minimal electrophysiological criteria (albeit aspecific) enough sensitive for CIDP diagnosis. PATIENTS AND METHODS: 20 patients with sensorimotor polyneuropathy, progressive for at least 2 months, with weakness in least two limbs and documented improvement in strength in response to immunotherapy. Other potential causes were excluded, including diabetes and IgM paraproteinemia with or without anti‐MAG reactivity. Twelve patients with axonal polyneuropathy associated with diabetes and 12 patients with amyotrophic lateral sclerosis were included as controls. Nerve conduction studies (NCS) were evaluated according to all five sets of NCS criteria and ROC was calculated. Likelihood ratio for CIDP was evaluated for each set of NCS criteria and for presence of each of the following features in different number of nerves: motor conduction velocities (MCV), conduction blocks/temporal dispersion, distal motor (DML) and F‐wave latencies (FWL). MCV, DML and FWL were considered indicative of demyelination if decreased or increased as suggested by AAN criteria. Results will be discussed. |
format |
Article in Journal/Newspaper |
author |
Cocito, D Chiò, A Isoardo, G Ciaramitaro, P Ghiglione, P Poglio, F Vercellino, M Mutani, R Bergamasco, B |
spellingShingle |
Cocito, D Chiò, A Isoardo, G Ciaramitaro, P Ghiglione, P Poglio, F Vercellino, M Mutani, R Bergamasco, B Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 57 |
author_facet |
Cocito, D Chiò, A Isoardo, G Ciaramitaro, P Ghiglione, P Poglio, F Vercellino, M Mutani, R Bergamasco, B |
author_sort |
Cocito, D |
title |
Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 57 |
title_short |
Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 57 |
title_full |
Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 57 |
title_fullStr |
Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 57 |
title_full_unstemmed |
Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 57 |
title_sort |
abstracts of the 8th meeting of the italian peripheral nerve study group: 57 |
publisher |
Wiley |
publishDate |
2003 |
url |
http://dx.doi.org/10.1046/j.1529-8027.2003.00057.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1529-8027.2003.00057.x |
genre |
DML |
genre_facet |
DML |
op_source |
Journal of the Peripheral Nervous System volume 8, issue 1, page 29-58 ISSN 1085-9489 1529-8027 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1529-8027.2003.00057.x |
container_title |
Journal of the Peripheral Nervous System |
container_volume |
8 |
container_issue |
1 |
container_start_page |
29 |
op_container_end_page |
58 |
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1800750687335743488 |