Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA
Abstract Neurons can communicate with each other either via exchange of specific molecules at synapses or by direct electrical connections between the cytoplasm of either cell [for review see Bruzzone et al. (1996) Eur. J. Biochem ., 238 , 1–27]. Although electrical connections are abundant in many...
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crwiley:10.1046/j.1460-9568.2002.02423.x 2024-09-30T14:33:50+00:00 Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA Kelmanson, Ilya V. Shagin, Dmitry A. Usman, Natalia Matz, Mikhail V. Lukyanov, Sergey A. Panchin, Yury V. 2002 http://dx.doi.org/10.1046/j.1460-9568.2002.02423.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1460-9568.2002.02423.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1460-9568.2002.02423.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor European Journal of Neuroscience volume 16, issue 12, page 2475-2476 ISSN 0953-816X 1460-9568 journal-article 2002 crwiley https://doi.org/10.1046/j.1460-9568.2002.02423.x 2024-09-05T05:07:52Z Abstract Neurons can communicate with each other either via exchange of specific molecules at synapses or by direct electrical connections between the cytoplasm of either cell [for review see Bruzzone et al. (1996) Eur. J. Biochem ., 238 , 1–27]. Although electrical connections are abundant in many nervous systems, little is known about the mechanisms which govern the specificity of their formation. Recent cloning of the innexins – gap junction proteins responsible for electrical coupling in invertebrates (Phelan et al. (1998) Trends Genet ., 14 , 348–349], has made it possible to study the molecular mechanisms of patterning of the electrical connections between individual neurons in model systems. Here we demonstrate that intracellular injection of mRNA encoding the molluscan innexin Panx1 (Panchin et al . 2000 Curr. Biol., 10 , R473‐R474) drastically alters the specificity of electrical coupling between identified neurons of the pteropod mollusc Clione limacina . Article in Journal/Newspaper Clione limacina Wiley Online Library European Journal of Neuroscience 16 12 2475 2476 |
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Open Polar |
collection |
Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract Neurons can communicate with each other either via exchange of specific molecules at synapses or by direct electrical connections between the cytoplasm of either cell [for review see Bruzzone et al. (1996) Eur. J. Biochem ., 238 , 1–27]. Although electrical connections are abundant in many nervous systems, little is known about the mechanisms which govern the specificity of their formation. Recent cloning of the innexins – gap junction proteins responsible for electrical coupling in invertebrates (Phelan et al. (1998) Trends Genet ., 14 , 348–349], has made it possible to study the molecular mechanisms of patterning of the electrical connections between individual neurons in model systems. Here we demonstrate that intracellular injection of mRNA encoding the molluscan innexin Panx1 (Panchin et al . 2000 Curr. Biol., 10 , R473‐R474) drastically alters the specificity of electrical coupling between identified neurons of the pteropod mollusc Clione limacina . |
format |
Article in Journal/Newspaper |
author |
Kelmanson, Ilya V. Shagin, Dmitry A. Usman, Natalia Matz, Mikhail V. Lukyanov, Sergey A. Panchin, Yury V. |
spellingShingle |
Kelmanson, Ilya V. Shagin, Dmitry A. Usman, Natalia Matz, Mikhail V. Lukyanov, Sergey A. Panchin, Yury V. Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA |
author_facet |
Kelmanson, Ilya V. Shagin, Dmitry A. Usman, Natalia Matz, Mikhail V. Lukyanov, Sergey A. Panchin, Yury V. |
author_sort |
Kelmanson, Ilya V. |
title |
Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA |
title_short |
Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA |
title_full |
Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA |
title_fullStr |
Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA |
title_full_unstemmed |
Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA |
title_sort |
altering electrical connections in the nervous system of the pteropod mollusc clione limacina by neuronal injections of gap junction mrna |
publisher |
Wiley |
publishDate |
2002 |
url |
http://dx.doi.org/10.1046/j.1460-9568.2002.02423.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1460-9568.2002.02423.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1460-9568.2002.02423.x |
genre |
Clione limacina |
genre_facet |
Clione limacina |
op_source |
European Journal of Neuroscience volume 16, issue 12, page 2475-2476 ISSN 0953-816X 1460-9568 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1460-9568.2002.02423.x |
container_title |
European Journal of Neuroscience |
container_volume |
16 |
container_issue |
12 |
container_start_page |
2475 |
op_container_end_page |
2476 |
_version_ |
1811637618508562432 |