Amoxicillin pharmacokinetics in harbor seals ( Phoca vitulina) and northern elephant seals ( Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing
The pharmacokinetics of sodium amoxicillin after a single intravenous dose of 20 mg/kg were determined in ten harbor seals ( Phoca vitulina ) and ten northern elephant seals ( Mirounga angustirostris ). The seals ranged in age from 1 to 6 months and the mean weights were 11.7 kg (range, 9.5–18.5 kg)...
Published in: | Journal of Veterinary Pharmacology and Therapeutics |
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Online Access: | http://dx.doi.org/10.1046/j.1365-2885.2000.00263.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2885.2000.00263.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2885.2000.00263.x |
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crwiley:10.1046/j.1365-2885.2000.00263.x 2024-06-02T08:06:01+00:00 Amoxicillin pharmacokinetics in harbor seals ( Phoca vitulina) and northern elephant seals ( Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing GULLAND, F. M. STOSKOPF, M. K. JOHNSON, S. P. RIVIERE, J. PAPICH, M. G. 2000 http://dx.doi.org/10.1046/j.1365-2885.2000.00263.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2885.2000.00263.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2885.2000.00263.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Veterinary Pharmacology and Therapeutics volume 23, issue 4, page 223-228 ISSN 0140-7783 1365-2885 journal-article 2000 crwiley https://doi.org/10.1046/j.1365-2885.2000.00263.x 2024-05-03T11:32:46Z The pharmacokinetics of sodium amoxicillin after a single intravenous dose of 20 mg/kg were determined in ten harbor seals ( Phoca vitulina ) and ten northern elephant seals ( Mirounga angustirostris ). The seals ranged in age from 1 to 6 months and the mean weights were 11.7 kg (range, 9.5–18.5 kg) for harbor seals and 47.1 kg (range, 39.5–61.4 kg) for elephant seals. The median half‐life of amoxicillin (quartiles) in harbor seals, 1.5 (1.0–3.1) h, was not statistically different from that of elephant seals, 2.0 (1.4–3.8) h, nor were the differences between the terminal elimination rate constants between the two species. The only statistically significant differences between species were for area‐under‐the‐curve ( AUC ), and total systemic clearance. The lack of statistical significance for differences in the volume of distribution at steady‐state ( V ss) may have been due to minor differences in the time frame of data collection and dose administered between the two groups. A true physiologic difference in drug handling, possibly related to renal perfusion or tubal secretory efficiency could affect amoxicillin kinetics in these species, and longer administration intervals may be appropriate for elephant seals as compared to harbor seals when administering multiple dose amoxicillin therapy at 20 mg/kg. Article in Journal/Newspaper Elephant Seals Phoca vitulina Wiley Online Library Journal of Veterinary Pharmacology and Therapeutics 23 4 223 228 |
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English |
description |
The pharmacokinetics of sodium amoxicillin after a single intravenous dose of 20 mg/kg were determined in ten harbor seals ( Phoca vitulina ) and ten northern elephant seals ( Mirounga angustirostris ). The seals ranged in age from 1 to 6 months and the mean weights were 11.7 kg (range, 9.5–18.5 kg) for harbor seals and 47.1 kg (range, 39.5–61.4 kg) for elephant seals. The median half‐life of amoxicillin (quartiles) in harbor seals, 1.5 (1.0–3.1) h, was not statistically different from that of elephant seals, 2.0 (1.4–3.8) h, nor were the differences between the terminal elimination rate constants between the two species. The only statistically significant differences between species were for area‐under‐the‐curve ( AUC ), and total systemic clearance. The lack of statistical significance for differences in the volume of distribution at steady‐state ( V ss) may have been due to minor differences in the time frame of data collection and dose administered between the two groups. A true physiologic difference in drug handling, possibly related to renal perfusion or tubal secretory efficiency could affect amoxicillin kinetics in these species, and longer administration intervals may be appropriate for elephant seals as compared to harbor seals when administering multiple dose amoxicillin therapy at 20 mg/kg. |
format |
Article in Journal/Newspaper |
author |
GULLAND, F. M. STOSKOPF, M. K. JOHNSON, S. P. RIVIERE, J. PAPICH, M. G. |
spellingShingle |
GULLAND, F. M. STOSKOPF, M. K. JOHNSON, S. P. RIVIERE, J. PAPICH, M. G. Amoxicillin pharmacokinetics in harbor seals ( Phoca vitulina) and northern elephant seals ( Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing |
author_facet |
GULLAND, F. M. STOSKOPF, M. K. JOHNSON, S. P. RIVIERE, J. PAPICH, M. G. |
author_sort |
GULLAND, F. M. |
title |
Amoxicillin pharmacokinetics in harbor seals ( Phoca vitulina) and northern elephant seals ( Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing |
title_short |
Amoxicillin pharmacokinetics in harbor seals ( Phoca vitulina) and northern elephant seals ( Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing |
title_full |
Amoxicillin pharmacokinetics in harbor seals ( Phoca vitulina) and northern elephant seals ( Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing |
title_fullStr |
Amoxicillin pharmacokinetics in harbor seals ( Phoca vitulina) and northern elephant seals ( Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing |
title_full_unstemmed |
Amoxicillin pharmacokinetics in harbor seals ( Phoca vitulina) and northern elephant seals ( Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing |
title_sort |
amoxicillin pharmacokinetics in harbor seals ( phoca vitulina) and northern elephant seals ( mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing |
publisher |
Wiley |
publishDate |
2000 |
url |
http://dx.doi.org/10.1046/j.1365-2885.2000.00263.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2885.2000.00263.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2885.2000.00263.x |
genre |
Elephant Seals Phoca vitulina |
genre_facet |
Elephant Seals Phoca vitulina |
op_source |
Journal of Veterinary Pharmacology and Therapeutics volume 23, issue 4, page 223-228 ISSN 0140-7783 1365-2885 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1365-2885.2000.00263.x |
container_title |
Journal of Veterinary Pharmacology and Therapeutics |
container_volume |
23 |
container_issue |
4 |
container_start_page |
223 |
op_container_end_page |
228 |
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1800750907355299840 |