Single‐dose pharmacokinetics of flumequine in halibut ( Hippoglossus hippoglossus) and turbot ( Scophthalmus maximus)

• Published in: Journal of Veterinary Pharmacology and Therapeutics
• Main Authors: Hansen, Horsberg
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1999
• Subjects: Scophthalmus maximus; Turbot
• Online Access: http://dx.doi.org/10.1046/j.1365-2885.1999.00191.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2885.1999.00191.x; https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2885.1999.00191.x

Flumequine was administered to halibut ( Hippoglossus hippoglossus ) and turbot ( Scophthalmus maximus ) intravenously (i.v.) and orally (p.o.) at a dose of 10 mg/kg bodyweight, and as a bath‐treatment at a dose of 10 mg/L water for 2 h, using identical experimental designs. The study was performed in seawater with a salinity of 3% and a temperature of 10.3 ± 0.4°C (halibut) and 18.0 ± 0.3 °C (turbot). Pharmacokinetic modelling of the data showed that flumequine had quite similar pharmacokinetic properties in halibut and turbot. Following intravenous administration, the volumes of distribution at steady state ( V ss ) were 2.99 L/kg (halibut) and 3.75 L/kg (turbot). Plasma clearances ( Cl ) were 0.12 L/kg (halibut) and 0.17 L/h.kg (turbot) and the elimination half‐lives ( t ½λ z ) were calculated to be 32 h (halibut) and 34 h (turbot). Mean residence times ( MRT ) were 25.1 h (halibut) and 22.2 h (turbot). Following oral administration, the t ½λz were 43 h (halibut) and 42 h (turbot). Maximal plasma concentrations ( t max ) were 1.4 mg/L (halibut) and 1.9 mg/L (turbot), and were observed 7 h post administration in both species. The oral bioavailabilities ( F ) were calculated to 56% (halibut) and 59% (turbot). Following bath administration maximal plasma concentrations were 0.08 mg/L (halibut) and 0.14 mg/L (turbot), and were observed 0 h (halibut) and 3 h (turbot) after the end of the bath. The bioavailability in halibut following a 2‐h bath treatment was 5%.