The association between leptin and proinsulin is lost with central obesity
Abstract. Söderberg S, Ahrén B, Eliasson M, DinesenB, Olsson T (Umeå University, Umeå, Lund University and Luleå Hospital, Lund, Sweden; and Steno Diabetes Center, Gentofte, Denmark). The association between leptin and proinsulin is lost with central obesity. J Intern Med 2002; 252: 140–148. Objecti...
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crwiley:10.1046/j.1365-2796.2002.01018.x 2024-06-02T08:10:12+00:00 The association between leptin and proinsulin is lost with central obesity Söderberg, S. AhrÉn, B. Eliasson, M. Dinesen, B. Olsson, T. 2002 http://dx.doi.org/10.1046/j.1365-2796.2002.01018.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2002.01018.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2002.01018.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Internal Medicine volume 252, issue 2, page 140-148 ISSN 0954-6820 1365-2796 journal-article 2002 crwiley https://doi.org/10.1046/j.1365-2796.2002.01018.x 2024-05-03T10:57:37Z Abstract. Söderberg S, Ahrén B, Eliasson M, DinesenB, Olsson T (Umeå University, Umeå, Lund University and Luleå Hospital, Lund, Sweden; and Steno Diabetes Center, Gentofte, Denmark). The association between leptin and proinsulin is lost with central obesity. J Intern Med 2002; 252: 140–148. Objective. Hyperproinsulinaemia and hyperleptinaemia are interrelated features of the insulin resistance syndrome that are linked to the prospective risk of cardiovascular diseases. Whether the association between leptin and proinsulin is different between groups displaying different degrees of risk for cardiovascular diseases is not known. We therefore examined this association in men versus women and in pre‐ versus postmenopausal women from a population‐based sample. Design and subjects. Healthy subjects ( n = 158; 85 men and 73 pre‐ and postmenopausal women) from the Northern Sweden Monitoring of Trends and Determinants in Cardiovascular Disease population were studied with a cross‐sectional design. Methods. Anthropometric measurements (body mass index and waist circumference) and oral glucose tolerance tests were performed. Enzyme‐linked immunosorbent assays were used for the analyses of specific insulin and proinsulin, and radioimmunoassay for leptin. Insulin resistance and β‐cell function were calculated according to the homeostasis assessment model. Partial correlation coefficients adjusted for age and measures of adiposity were calculated and multiple linear regression analyses were performed with leptin as dependent variable. Results. In nonobese men and premenopausal women and in obese postmenopausal women, leptin was significantly associated with proinsulin after stratification for waist circumference. Furthermore, a multivariate analyses taking age and measures of adiposity into account, showed that high fasting proinsulin was a significant predictor of high leptin in these groups. In contrast, this association was lost with increasing central obesity in men and premenopausal women. Conclusions. This study shows ... Article in Journal/Newspaper Luleå Luleå Luleå Northern Sweden Wiley Online Library Journal of Internal Medicine 252 2 140 148 |
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Wiley Online Library |
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English |
description |
Abstract. Söderberg S, Ahrén B, Eliasson M, DinesenB, Olsson T (Umeå University, Umeå, Lund University and Luleå Hospital, Lund, Sweden; and Steno Diabetes Center, Gentofte, Denmark). The association between leptin and proinsulin is lost with central obesity. J Intern Med 2002; 252: 140–148. Objective. Hyperproinsulinaemia and hyperleptinaemia are interrelated features of the insulin resistance syndrome that are linked to the prospective risk of cardiovascular diseases. Whether the association between leptin and proinsulin is different between groups displaying different degrees of risk for cardiovascular diseases is not known. We therefore examined this association in men versus women and in pre‐ versus postmenopausal women from a population‐based sample. Design and subjects. Healthy subjects ( n = 158; 85 men and 73 pre‐ and postmenopausal women) from the Northern Sweden Monitoring of Trends and Determinants in Cardiovascular Disease population were studied with a cross‐sectional design. Methods. Anthropometric measurements (body mass index and waist circumference) and oral glucose tolerance tests were performed. Enzyme‐linked immunosorbent assays were used for the analyses of specific insulin and proinsulin, and radioimmunoassay for leptin. Insulin resistance and β‐cell function were calculated according to the homeostasis assessment model. Partial correlation coefficients adjusted for age and measures of adiposity were calculated and multiple linear regression analyses were performed with leptin as dependent variable. Results. In nonobese men and premenopausal women and in obese postmenopausal women, leptin was significantly associated with proinsulin after stratification for waist circumference. Furthermore, a multivariate analyses taking age and measures of adiposity into account, showed that high fasting proinsulin was a significant predictor of high leptin in these groups. In contrast, this association was lost with increasing central obesity in men and premenopausal women. Conclusions. This study shows ... |
format |
Article in Journal/Newspaper |
author |
Söderberg, S. AhrÉn, B. Eliasson, M. Dinesen, B. Olsson, T. |
spellingShingle |
Söderberg, S. AhrÉn, B. Eliasson, M. Dinesen, B. Olsson, T. The association between leptin and proinsulin is lost with central obesity |
author_facet |
Söderberg, S. AhrÉn, B. Eliasson, M. Dinesen, B. Olsson, T. |
author_sort |
Söderberg, S. |
title |
The association between leptin and proinsulin is lost with central obesity |
title_short |
The association between leptin and proinsulin is lost with central obesity |
title_full |
The association between leptin and proinsulin is lost with central obesity |
title_fullStr |
The association between leptin and proinsulin is lost with central obesity |
title_full_unstemmed |
The association between leptin and proinsulin is lost with central obesity |
title_sort |
association between leptin and proinsulin is lost with central obesity |
publisher |
Wiley |
publishDate |
2002 |
url |
http://dx.doi.org/10.1046/j.1365-2796.2002.01018.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2002.01018.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2002.01018.x |
genre |
Luleå Luleå Luleå Northern Sweden |
genre_facet |
Luleå Luleå Luleå Northern Sweden |
op_source |
Journal of Internal Medicine volume 252, issue 2, page 140-148 ISSN 0954-6820 1365-2796 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1365-2796.2002.01018.x |
container_title |
Journal of Internal Medicine |
container_volume |
252 |
container_issue |
2 |
container_start_page |
140 |
op_container_end_page |
148 |
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1800756035577708544 |