Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort
Abstract. Karvonen J, Kauma H, Kervinen K, Rantala M, Ikäheimo M, Päivänsalo M, Savolainen MJ, Kesäniemi YA (University of Oulu, Oulu; Finland). Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐...
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crwiley:10.1046/j.1365-2796.2002.00933.x 2024-09-30T14:40:08+00:00 Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort Karvonen, J. Kauma, H. Kervinen, K. Rantala, M. Ikäheimo, M. Päivänsalo, M. Savolainen, M. J. Kesäniemi, Y. A. 2002 http://dx.doi.org/10.1046/j.1365-2796.2002.00933.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2002.00933.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2002.00933.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Internal Medicine volume 251, issue 2, page 102-110 ISSN 0954-6820 1365-2796 journal-article 2002 crwiley https://doi.org/10.1046/j.1365-2796.2002.00933.x 2024-09-17T04:50:59Z Abstract. Karvonen J, Kauma H, Kervinen K, Rantala M, Ikäheimo M, Päivänsalo M, Savolainen MJ, Kesäniemi YA (University of Oulu, Oulu; Finland). Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort. J Intern Med 2002; 251 : 102–110. Objective. Decreased production of endothelial nitric oxide (NO) is associated with different cardiovascular pathology. We studied the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima‐media thickness (IMT) in a population‐based cohort of hypertensive and control subjects. Design. Cross‐sectional case–control study. Setting. District around Oulu University Hospital, Northern Finland. Subjects and methods. The study population consisted of 600 middle‐aged hypertensive subjects (300 men and 300 women) and 600 controls (300 men and 300 women) living in the City of Oulu. The hypertensive subjects were randomly selected by age stratification from the Social Insurance Institute register for reimbursement of antihypertensive medication. For each hypertensive subject, an age‐ and sex‐matched control was randomly selected from the national health register. The overall participation rate was 87.8%. In the present study a total of 1024 subjects were screened. Echocardiographic examinations were performed by a trained cardiologist and carotid ultrasonographic examinations by a trained radiologist. Results. The genotype distributions and allele frequencies between the hypertensive and control subjects and the relationship between the Glu298Asp variant and blood pressure, LVM and carotid artery IMT were determined. No differences in genotype distribution or allele frequencies were found between the hypertensive and control groups (the frequency of the Asp allele 0.299 vs. 0.288, respectively). Also, we could not find any association between the eNOS ... Article in Journal/Newspaper Northern Finland Wiley Online Library Karvonen ENVELOPE(29.228,29.228,65.677,65.677) Kesäniemi ENVELOPE(28.919,28.919,66.204,66.204) Journal of Internal Medicine 251 2 102 110 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract. Karvonen J, Kauma H, Kervinen K, Rantala M, Ikäheimo M, Päivänsalo M, Savolainen MJ, Kesäniemi YA (University of Oulu, Oulu; Finland). Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort. J Intern Med 2002; 251 : 102–110. Objective. Decreased production of endothelial nitric oxide (NO) is associated with different cardiovascular pathology. We studied the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima‐media thickness (IMT) in a population‐based cohort of hypertensive and control subjects. Design. Cross‐sectional case–control study. Setting. District around Oulu University Hospital, Northern Finland. Subjects and methods. The study population consisted of 600 middle‐aged hypertensive subjects (300 men and 300 women) and 600 controls (300 men and 300 women) living in the City of Oulu. The hypertensive subjects were randomly selected by age stratification from the Social Insurance Institute register for reimbursement of antihypertensive medication. For each hypertensive subject, an age‐ and sex‐matched control was randomly selected from the national health register. The overall participation rate was 87.8%. In the present study a total of 1024 subjects were screened. Echocardiographic examinations were performed by a trained cardiologist and carotid ultrasonographic examinations by a trained radiologist. Results. The genotype distributions and allele frequencies between the hypertensive and control subjects and the relationship between the Glu298Asp variant and blood pressure, LVM and carotid artery IMT were determined. No differences in genotype distribution or allele frequencies were found between the hypertensive and control groups (the frequency of the Asp allele 0.299 vs. 0.288, respectively). Also, we could not find any association between the eNOS ... |
format |
Article in Journal/Newspaper |
author |
Karvonen, J. Kauma, H. Kervinen, K. Rantala, M. Ikäheimo, M. Päivänsalo, M. Savolainen, M. J. Kesäniemi, Y. A. |
spellingShingle |
Karvonen, J. Kauma, H. Kervinen, K. Rantala, M. Ikäheimo, M. Päivänsalo, M. Savolainen, M. J. Kesäniemi, Y. A. Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort |
author_facet |
Karvonen, J. Kauma, H. Kervinen, K. Rantala, M. Ikäheimo, M. Päivänsalo, M. Savolainen, M. J. Kesäniemi, Y. A. |
author_sort |
Karvonen, J. |
title |
Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort |
title_short |
Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort |
title_full |
Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort |
title_fullStr |
Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort |
title_full_unstemmed |
Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort |
title_sort |
endothelial nitric oxide synthase gene glu298asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort |
publisher |
Wiley |
publishDate |
2002 |
url |
http://dx.doi.org/10.1046/j.1365-2796.2002.00933.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2002.00933.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2002.00933.x |
long_lat |
ENVELOPE(29.228,29.228,65.677,65.677) ENVELOPE(28.919,28.919,66.204,66.204) |
geographic |
Karvonen Kesäniemi |
geographic_facet |
Karvonen Kesäniemi |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Journal of Internal Medicine volume 251, issue 2, page 102-110 ISSN 0954-6820 1365-2796 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1365-2796.2002.00933.x |
container_title |
Journal of Internal Medicine |
container_volume |
251 |
container_issue |
2 |
container_start_page |
102 |
op_container_end_page |
110 |
_version_ |
1811642665586917376 |