Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients
Abstract. Hardarson A, Sigurdsson G, Olafsdottir E, Dallongeville J, Berg A‐L, Arnadottir A (Landspitali University Hospital, Reykjavik, Iceland; Institut Pasteur, Lille, France; and University Hospital, Lund, Sweden). Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐...
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crwiley:10.1046/j.1365-2796.2001.00919.x 2024-06-02T08:09:25+00:00 Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients Hardarson, A. Sigurdsson, G. Olafsdottir, E. Dallongeville, J. Berg, A.‐L. Arnadottir, M. 2001 http://dx.doi.org/10.1046/j.1365-2796.2001.00919.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2001.00919.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2001.00919.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Internal Medicine volume 250, issue 6, page 530-534 ISSN 0954-6820 1365-2796 journal-article 2001 crwiley https://doi.org/10.1046/j.1365-2796.2001.00919.x 2024-05-03T11:35:57Z Abstract. Hardarson A, Sigurdsson G, Olafsdottir E, Dallongeville J, Berg A‐L, Arnadottir A (Landspitali University Hospital, Reykjavik, Iceland; Institut Pasteur, Lille, France; and University Hospital, Lund, Sweden). Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients. J Intern Med 2001; 250: 530–534. Objective. Recently, it was reported that treatment with adrenocorticotrophic hormone (ACTH) has a strong lipid‐lowering effect in healthy individuals. The mechanism behind this has not been established. The aim of the present investigation was to study the effect of ACTH on the plasma lipoprotein pattern in patients treated with a 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase inhibitor. Design. The ACTH treatment was given to 10 patients who were on long‐term treatment with simvastatin 40 mg daily. ACTH 1‐24 was administered at the dose of 1 mg daily for four consecutive days. Blood samples for analyses of lipids, lipoproteins and apolipoproteins were collected before and after treatment. Second baseline was obtained 2 weeks after the end of treatment. Results. The serum concentrations of cholesterol, triglycerides, low density lipoprotein (LDL) cholesterol, apolipoprotein B and lipoprotein(a) fell significantly by 16, 23, 23, 10 and 38%, respectively. The serum apolipoprotein E concentration increased significantly by 39%; the fraction that was not associated with apolipoprotein B increased by 47% whereas the fraction that was did not change significantly. There were no changes in the serum concentrations of high density lipoprotein (HDL) cholesterol and apolipoprotein AI. At the second baseline, the lipid variables had generally returned to previous levels. Conclusions. In patients on long‐term simvastatin treatment, ACTH had marked lowering effects on the lipoproteins that contain apolipoprotein B. Moreover, the serum apolipoprotein E concentration increased significantly in response to ACTH treatment. Article in Journal/Newspaper Iceland Wiley Online Library Pasteur ENVELOPE(140.099,140.099,-66.625,-66.625) Journal of Internal Medicine 250 6 530 534 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract. Hardarson A, Sigurdsson G, Olafsdottir E, Dallongeville J, Berg A‐L, Arnadottir A (Landspitali University Hospital, Reykjavik, Iceland; Institut Pasteur, Lille, France; and University Hospital, Lund, Sweden). Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients. J Intern Med 2001; 250: 530–534. Objective. Recently, it was reported that treatment with adrenocorticotrophic hormone (ACTH) has a strong lipid‐lowering effect in healthy individuals. The mechanism behind this has not been established. The aim of the present investigation was to study the effect of ACTH on the plasma lipoprotein pattern in patients treated with a 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase inhibitor. Design. The ACTH treatment was given to 10 patients who were on long‐term treatment with simvastatin 40 mg daily. ACTH 1‐24 was administered at the dose of 1 mg daily for four consecutive days. Blood samples for analyses of lipids, lipoproteins and apolipoproteins were collected before and after treatment. Second baseline was obtained 2 weeks after the end of treatment. Results. The serum concentrations of cholesterol, triglycerides, low density lipoprotein (LDL) cholesterol, apolipoprotein B and lipoprotein(a) fell significantly by 16, 23, 23, 10 and 38%, respectively. The serum apolipoprotein E concentration increased significantly by 39%; the fraction that was not associated with apolipoprotein B increased by 47% whereas the fraction that was did not change significantly. There were no changes in the serum concentrations of high density lipoprotein (HDL) cholesterol and apolipoprotein AI. At the second baseline, the lipid variables had generally returned to previous levels. Conclusions. In patients on long‐term simvastatin treatment, ACTH had marked lowering effects on the lipoproteins that contain apolipoprotein B. Moreover, the serum apolipoprotein E concentration increased significantly in response to ACTH treatment. |
format |
Article in Journal/Newspaper |
author |
Hardarson, A. Sigurdsson, G. Olafsdottir, E. Dallongeville, J. Berg, A.‐L. Arnadottir, M. |
spellingShingle |
Hardarson, A. Sigurdsson, G. Olafsdottir, E. Dallongeville, J. Berg, A.‐L. Arnadottir, M. Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients |
author_facet |
Hardarson, A. Sigurdsson, G. Olafsdottir, E. Dallongeville, J. Berg, A.‐L. Arnadottir, M. |
author_sort |
Hardarson, A. |
title |
Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients |
title_short |
Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients |
title_full |
Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients |
title_fullStr |
Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients |
title_full_unstemmed |
Adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients |
title_sort |
adrenocorticotrophic hormone exerts marked lipid‐lowering effects in simvastatin‐treated patients |
publisher |
Wiley |
publishDate |
2001 |
url |
http://dx.doi.org/10.1046/j.1365-2796.2001.00919.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2001.00919.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2001.00919.x |
long_lat |
ENVELOPE(140.099,140.099,-66.625,-66.625) |
geographic |
Pasteur |
geographic_facet |
Pasteur |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Journal of Internal Medicine volume 250, issue 6, page 530-534 ISSN 0954-6820 1365-2796 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1365-2796.2001.00919.x |
container_title |
Journal of Internal Medicine |
container_volume |
250 |
container_issue |
6 |
container_start_page |
530 |
op_container_end_page |
534 |
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1800755139702685696 |