Screening for adult coeliac disease – which serological marker(s) to use?
Abstract. Lagerqvist C, Ivarsson A, Juto P, Persson LÅ & Hernell O (Umeå University, Umeå, Sweden). Screening for adult coeliac disease – which serological marker(s) to use? J Intern Med 2001; 250: 241–248. Objective. To determine which serological marker(s) to use when screening for coeliac dis...
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crwiley:10.1046/j.1365-2796.2001.00891.x 2024-06-02T08:12:13+00:00 Screening for adult coeliac disease – which serological marker(s) to use? Lagerqvist, C. Ivarsson, A. Juto, P. Persson, L. Å. Hernell, O. 2001 http://dx.doi.org/10.1046/j.1365-2796.2001.00891.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2001.00891.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2001.00891.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Internal Medicine volume 250, issue 3, page 241-248 ISSN 0954-6820 1365-2796 journal-article 2001 crwiley https://doi.org/10.1046/j.1365-2796.2001.00891.x 2024-05-03T11:09:23Z Abstract. Lagerqvist C, Ivarsson A, Juto P, Persson LÅ & Hernell O (Umeå University, Umeå, Sweden). Screening for adult coeliac disease – which serological marker(s) to use? J Intern Med 2001; 250: 241–248. Objective. To determine which serological marker(s) to use when screening for coeliac disease. Design. In a population‐based cross‐sectional study we compared the use of antigliadin antibodies (AGA) of isotypes IgA and IgG, antiendomysial antibodies (AEA) of isotype IgA and antitransglutaminase antibodies (ATGA) of isotype IgA for detecting coeliac disease amongst adults. Setting. Northern Sweden. Subjects. A total of 1850 of 2500 (74%) invited adults (aged 25–74 years) who were randomly selected from the population register after stratification for age and sex. Main outcome measures. The sensitivity, specificity and predictive values of the AGA, ATGA and AEA tests. Results. Nine cases of biopsy proven, previously undiagnosed coeliac disease were detected by screening. The sensitivity of both ATGA and AEA was 100% whilst AGA IgA and IgG both had a sensitivity of 89%. The AEA test had a specificity of 100% whereas the specificities of the ATGA, AGA IgA and IgG tests were 97, 96 and 78%, respectively. The positive predictive value for the AEA test was 100%, whereas it was considerably lower for the other tests (ATGA > AGA IgA > AGA IgG), with further decreases for all tests when shifting from a clinical to a screening situation. Conclusions. When screening for coeliac disease we suggest a serial testing approach, i.e. an initial ATGA test and, when positive, followed by an AEA test, provided that IgA deficiency has been excluded. However, assessment of the small intestinal mucosal morphology is still required to ascertain the diagnosis. Article in Journal/Newspaper Northern Sweden Wiley Online Library Persson ENVELOPE(-58.400,-58.400,-64.200,-64.200) Journal of Internal Medicine 250 3 241 248 |
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Wiley Online Library |
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English |
description |
Abstract. Lagerqvist C, Ivarsson A, Juto P, Persson LÅ & Hernell O (Umeå University, Umeå, Sweden). Screening for adult coeliac disease – which serological marker(s) to use? J Intern Med 2001; 250: 241–248. Objective. To determine which serological marker(s) to use when screening for coeliac disease. Design. In a population‐based cross‐sectional study we compared the use of antigliadin antibodies (AGA) of isotypes IgA and IgG, antiendomysial antibodies (AEA) of isotype IgA and antitransglutaminase antibodies (ATGA) of isotype IgA for detecting coeliac disease amongst adults. Setting. Northern Sweden. Subjects. A total of 1850 of 2500 (74%) invited adults (aged 25–74 years) who were randomly selected from the population register after stratification for age and sex. Main outcome measures. The sensitivity, specificity and predictive values of the AGA, ATGA and AEA tests. Results. Nine cases of biopsy proven, previously undiagnosed coeliac disease were detected by screening. The sensitivity of both ATGA and AEA was 100% whilst AGA IgA and IgG both had a sensitivity of 89%. The AEA test had a specificity of 100% whereas the specificities of the ATGA, AGA IgA and IgG tests were 97, 96 and 78%, respectively. The positive predictive value for the AEA test was 100%, whereas it was considerably lower for the other tests (ATGA > AGA IgA > AGA IgG), with further decreases for all tests when shifting from a clinical to a screening situation. Conclusions. When screening for coeliac disease we suggest a serial testing approach, i.e. an initial ATGA test and, when positive, followed by an AEA test, provided that IgA deficiency has been excluded. However, assessment of the small intestinal mucosal morphology is still required to ascertain the diagnosis. |
format |
Article in Journal/Newspaper |
author |
Lagerqvist, C. Ivarsson, A. Juto, P. Persson, L. Å. Hernell, O. |
spellingShingle |
Lagerqvist, C. Ivarsson, A. Juto, P. Persson, L. Å. Hernell, O. Screening for adult coeliac disease – which serological marker(s) to use? |
author_facet |
Lagerqvist, C. Ivarsson, A. Juto, P. Persson, L. Å. Hernell, O. |
author_sort |
Lagerqvist, C. |
title |
Screening for adult coeliac disease – which serological marker(s) to use? |
title_short |
Screening for adult coeliac disease – which serological marker(s) to use? |
title_full |
Screening for adult coeliac disease – which serological marker(s) to use? |
title_fullStr |
Screening for adult coeliac disease – which serological marker(s) to use? |
title_full_unstemmed |
Screening for adult coeliac disease – which serological marker(s) to use? |
title_sort |
screening for adult coeliac disease – which serological marker(s) to use? |
publisher |
Wiley |
publishDate |
2001 |
url |
http://dx.doi.org/10.1046/j.1365-2796.2001.00891.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2001.00891.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2001.00891.x |
long_lat |
ENVELOPE(-58.400,-58.400,-64.200,-64.200) |
geographic |
Persson |
geographic_facet |
Persson |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Journal of Internal Medicine volume 250, issue 3, page 241-248 ISSN 0954-6820 1365-2796 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1365-2796.2001.00891.x |
container_title |
Journal of Internal Medicine |
container_volume |
250 |
container_issue |
3 |
container_start_page |
241 |
op_container_end_page |
248 |
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1800758592925597696 |