Primary biliary cirrhosis: survival of a cohort followed for 10 years
Abstract. Uddenfeldt P, Danielsson Å (County Hospital Gävle and University Hospital Umeå, Sweden). Primary biliary cirrhosis: survival of a cohort followed for 10 years. J Intern Med 2000; 248: 292–298. Objectives. To study the natural course of primary biliary cirrhosis (PBC) in order to be able to...
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crwiley:10.1046/j.1365-2796.2000.00733.x 2024-06-02T08:12:13+00:00 Primary biliary cirrhosis: survival of a cohort followed for 10 years Uddenfeldt, P. Danielsson, Å. 2000 http://dx.doi.org/10.1046/j.1365-2796.2000.00733.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2000.00733.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2000.00733.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Internal Medicine volume 248, issue 4, page 292-298 ISSN 0954-6820 1365-2796 journal-article 2000 crwiley https://doi.org/10.1046/j.1365-2796.2000.00733.x 2024-05-03T12:07:00Z Abstract. Uddenfeldt P, Danielsson Å (County Hospital Gävle and University Hospital Umeå, Sweden). Primary biliary cirrhosis: survival of a cohort followed for 10 years. J Intern Med 2000; 248: 292–298. Objectives. To study the natural course of primary biliary cirrhosis (PBC) in order to be able to design accurate clinical pharmacological studies and evaluate the need for liver transplantation. Design. A cohort of 86 patients with PBC living in northern Sweden was followed for a 10‐year period during 1983–93. No patients received therapy with ursodeoxy cholic acid or other drugs during the follow‐up period. Method. At start all patients were investigated personally by the authors. At follow‐up medical notes were scrutinized and special questionnaires to the current responsible physician were applied. End‐points were the time of dropout, liver transplantation, death or end of the study period. Results. At follow‐up data were available for 84 patients (97%). During the study period 34 patients died, of whom 28 were symptomatic; 15 deaths had no direct connection to PBC. Nineteen deaths were related to PBC of whom two were asymptomatic, the most common cause being end‐stage liver disease with liver coma. During the study period in all eight patients were subjected to liver transplantation. Conclusions. The survival rate of the 32 asymptomatic PBC patients at the start of the study was the same as a sex‐ and age‐matched standard background population. Those patients with symptomatic PBC from the beginning of study had a survival rate at 10 years of 50%, and the most ominous sign was a bilirubin greater than 35 µmol L −1 . Liver transplantation was performed in almost 10% in this cohort until 1993. Since then, the indications and referral practice for liver transplantation has changed and is now higher. Article in Journal/Newspaper Northern Sweden Wiley Online Library Journal of Internal Medicine 248 4 292 298 |
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Abstract. Uddenfeldt P, Danielsson Å (County Hospital Gävle and University Hospital Umeå, Sweden). Primary biliary cirrhosis: survival of a cohort followed for 10 years. J Intern Med 2000; 248: 292–298. Objectives. To study the natural course of primary biliary cirrhosis (PBC) in order to be able to design accurate clinical pharmacological studies and evaluate the need for liver transplantation. Design. A cohort of 86 patients with PBC living in northern Sweden was followed for a 10‐year period during 1983–93. No patients received therapy with ursodeoxy cholic acid or other drugs during the follow‐up period. Method. At start all patients were investigated personally by the authors. At follow‐up medical notes were scrutinized and special questionnaires to the current responsible physician were applied. End‐points were the time of dropout, liver transplantation, death or end of the study period. Results. At follow‐up data were available for 84 patients (97%). During the study period 34 patients died, of whom 28 were symptomatic; 15 deaths had no direct connection to PBC. Nineteen deaths were related to PBC of whom two were asymptomatic, the most common cause being end‐stage liver disease with liver coma. During the study period in all eight patients were subjected to liver transplantation. Conclusions. The survival rate of the 32 asymptomatic PBC patients at the start of the study was the same as a sex‐ and age‐matched standard background population. Those patients with symptomatic PBC from the beginning of study had a survival rate at 10 years of 50%, and the most ominous sign was a bilirubin greater than 35 µmol L −1 . Liver transplantation was performed in almost 10% in this cohort until 1993. Since then, the indications and referral practice for liver transplantation has changed and is now higher. |
format |
Article in Journal/Newspaper |
author |
Uddenfeldt, P. Danielsson, Å. |
spellingShingle |
Uddenfeldt, P. Danielsson, Å. Primary biliary cirrhosis: survival of a cohort followed for 10 years |
author_facet |
Uddenfeldt, P. Danielsson, Å. |
author_sort |
Uddenfeldt, P. |
title |
Primary biliary cirrhosis: survival of a cohort followed for 10 years |
title_short |
Primary biliary cirrhosis: survival of a cohort followed for 10 years |
title_full |
Primary biliary cirrhosis: survival of a cohort followed for 10 years |
title_fullStr |
Primary biliary cirrhosis: survival of a cohort followed for 10 years |
title_full_unstemmed |
Primary biliary cirrhosis: survival of a cohort followed for 10 years |
title_sort |
primary biliary cirrhosis: survival of a cohort followed for 10 years |
publisher |
Wiley |
publishDate |
2000 |
url |
http://dx.doi.org/10.1046/j.1365-2796.2000.00733.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.2000.00733.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.2000.00733.x |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Journal of Internal Medicine volume 248, issue 4, page 292-298 ISSN 0954-6820 1365-2796 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1365-2796.2000.00733.x |
container_title |
Journal of Internal Medicine |
container_volume |
248 |
container_issue |
4 |
container_start_page |
292 |
op_container_end_page |
298 |
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1800758585102172160 |