Leptin is associated with increased risk of myocardial infarction
Abstract. Söderberg S, Ahrén B, Jansson J‐H, Johnson O, Hallmans G, Asplund K, Olsson T (Umeå University, Umeå; and Lund University, Malmö, Sweden). Leptin is associated with increased risk of myocardial infarction. J Intern Med 1999; 246: 409–418. Objectives and design. Leptin is involved in the re...
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Online Access: | http://dx.doi.org/10.1046/j.1365-2796.1999.00571.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.1999.00571.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.1999.00571.x |
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crwiley:10.1046/j.1365-2796.1999.00571.x 2024-10-13T14:09:50+00:00 Leptin is associated with increased risk of myocardial infarction Söderberg, S. Ahrén, B. Jansson, J.‐H. Johnson, O. Hallmans, G. Asplund, K. Olsson, T. 1999 http://dx.doi.org/10.1046/j.1365-2796.1999.00571.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.1999.00571.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.1999.00571.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Internal Medicine volume 246, issue 4, page 409-418 ISSN 0954-6820 1365-2796 journal-article 1999 crwiley https://doi.org/10.1046/j.1365-2796.1999.00571.x 2024-09-17T04:46:48Z Abstract. Söderberg S, Ahrén B, Jansson J‐H, Johnson O, Hallmans G, Asplund K, Olsson T (Umeå University, Umeå; and Lund University, Malmö, Sweden). Leptin is associated with increased risk of myocardial infarction. J Intern Med 1999; 246: 409–418. Objectives and design. Leptin is involved in the regulation of bodyweight and metabolism in man and might also be involved in the pathophysiology of the insulin resistance syndrome, which is associated with the development of cardiovascular diseases. We tested whether leptin is a risk factor for acute myocardial infarction (AMI) in a nested case‐referent study. Subjects and methods. Sixty‐two men with first‐ever AMI were identified who, prior to AMI, had participated in population‐based health surveys in Northern Sweden. Referents were matched for sex, age, date and type of health survey, and geographical region. Blood pressure, body mass index (BMI) and the presence of smoking, diabetes and hypertension were recorded. Total cholesterol, apolipoprotein A‐1 (apo A‐1), apolipoprotein B (apo B), plasminogen activator inhibitor (PAI‐1), insulin, and leptin were analysed in stored samples. Their influences on first‐ever AMI were analysed by conditional logistic regression analysis. Results. Men with first‐ever AMI had higher BMI, plasma insulin and leptin, and diastolic blood pressure than the referents. Furthermore, they had lower plasma apo A‐1 and were more often smokers. Smoking, high leptin, PAI‐1 and cholesterol, and low apo A‐1 levels were significant risk factors for first‐ever AMI in univariate analysis. High leptin (OR 8.97; 95% CI: 1.73–46.5) and cholesterol (OR 5.18; 95% CI: 1.34–20.0) levels remained significant risk factors for AMI in a multivariate model. High apo A‐1 was protective (OR = 0.13; 95% CI: 0.03–0.55). The combination of high leptin and low apo A‐1 was associated with a particularly pronounced increased risk for AMI. Conclusion. Plasma leptin strongly predicts first‐ever AMI. Our data support the hypothesis that leptin is an important link in the ... Article in Journal/Newspaper Northern Sweden Wiley Online Library Journal of Internal Medicine 246 4 409 418 |
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Wiley Online Library |
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English |
description |
Abstract. Söderberg S, Ahrén B, Jansson J‐H, Johnson O, Hallmans G, Asplund K, Olsson T (Umeå University, Umeå; and Lund University, Malmö, Sweden). Leptin is associated with increased risk of myocardial infarction. J Intern Med 1999; 246: 409–418. Objectives and design. Leptin is involved in the regulation of bodyweight and metabolism in man and might also be involved in the pathophysiology of the insulin resistance syndrome, which is associated with the development of cardiovascular diseases. We tested whether leptin is a risk factor for acute myocardial infarction (AMI) in a nested case‐referent study. Subjects and methods. Sixty‐two men with first‐ever AMI were identified who, prior to AMI, had participated in population‐based health surveys in Northern Sweden. Referents were matched for sex, age, date and type of health survey, and geographical region. Blood pressure, body mass index (BMI) and the presence of smoking, diabetes and hypertension were recorded. Total cholesterol, apolipoprotein A‐1 (apo A‐1), apolipoprotein B (apo B), plasminogen activator inhibitor (PAI‐1), insulin, and leptin were analysed in stored samples. Their influences on first‐ever AMI were analysed by conditional logistic regression analysis. Results. Men with first‐ever AMI had higher BMI, plasma insulin and leptin, and diastolic blood pressure than the referents. Furthermore, they had lower plasma apo A‐1 and were more often smokers. Smoking, high leptin, PAI‐1 and cholesterol, and low apo A‐1 levels were significant risk factors for first‐ever AMI in univariate analysis. High leptin (OR 8.97; 95% CI: 1.73–46.5) and cholesterol (OR 5.18; 95% CI: 1.34–20.0) levels remained significant risk factors for AMI in a multivariate model. High apo A‐1 was protective (OR = 0.13; 95% CI: 0.03–0.55). The combination of high leptin and low apo A‐1 was associated with a particularly pronounced increased risk for AMI. Conclusion. Plasma leptin strongly predicts first‐ever AMI. Our data support the hypothesis that leptin is an important link in the ... |
format |
Article in Journal/Newspaper |
author |
Söderberg, S. Ahrén, B. Jansson, J.‐H. Johnson, O. Hallmans, G. Asplund, K. Olsson, T. |
spellingShingle |
Söderberg, S. Ahrén, B. Jansson, J.‐H. Johnson, O. Hallmans, G. Asplund, K. Olsson, T. Leptin is associated with increased risk of myocardial infarction |
author_facet |
Söderberg, S. Ahrén, B. Jansson, J.‐H. Johnson, O. Hallmans, G. Asplund, K. Olsson, T. |
author_sort |
Söderberg, S. |
title |
Leptin is associated with increased risk of myocardial infarction |
title_short |
Leptin is associated with increased risk of myocardial infarction |
title_full |
Leptin is associated with increased risk of myocardial infarction |
title_fullStr |
Leptin is associated with increased risk of myocardial infarction |
title_full_unstemmed |
Leptin is associated with increased risk of myocardial infarction |
title_sort |
leptin is associated with increased risk of myocardial infarction |
publisher |
Wiley |
publishDate |
1999 |
url |
http://dx.doi.org/10.1046/j.1365-2796.1999.00571.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2796.1999.00571.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2796.1999.00571.x |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Journal of Internal Medicine volume 246, issue 4, page 409-418 ISSN 0954-6820 1365-2796 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1365-2796.1999.00571.x |
container_title |
Journal of Internal Medicine |
container_volume |
246 |
container_issue |
4 |
container_start_page |
409 |
op_container_end_page |
418 |
_version_ |
1812816895487770624 |