A population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome
From July 1984 the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) have registered all children with acute myeloid leukaemia (AML) and treated them on two consecutive protocols of different intensity (NOPHO‐84 and NOPHO‐88). We probably have information on every child with this...
Published in: | British Journal of Haematology |
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Online Access: | http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1761.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2141.1996.d01-1761.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2141.1996.d01-1761.x |
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crwiley:10.1046/j.1365-2141.1996.d01-1761.x 2024-06-02T08:09:21+00:00 A population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome Lie, Sverre O. Jonmundsson, Gudmundur Mellander, Lotta Siimes, Martti A. Yssing, Minna G ustafsson, Göran 1996 http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1761.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2141.1996.d01-1761.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2141.1996.d01-1761.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor British Journal of Haematology volume 94, issue 1, page 82-88 ISSN 0007-1048 1365-2141 journal-article 1996 crwiley https://doi.org/10.1046/j.1365-2141.1996.d01-1761.x 2024-05-03T11:23:19Z From July 1984 the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) have registered all children with acute myeloid leukaemia (AML) and treated them on two consecutive protocols of different intensity (NOPHO‐84 and NOPHO‐88). We probably have information on every child with this diagnosis in our region. We found an annual incidence of AML of 0.7 new cases per 100 000 children <16 years of age. We observed a distinct peak of incidence in the first 2 years of life. Children with Down’s syndrome accounted for 13% of all cases. Eighty of 105 cases treated on NOPHO‐84 achieved remission (78%). In NOPHO‐88, 100/118 patients entered remission (85%). The overall event‐free survival (p‐EFS) for the two studies was 0.32 for NOPHO‐84 and 0.42 for NOPHO‐88. The majority of relapses occurred within 2 years of diagnosis. When looking for prognostic factors the strongest significant adverse factor found was male sex. Children with Down’s syndrome ( n =35) had a very favourable outcome if they received therapy according to protocol, and infants ( n =26) had a superior outcome compared to children 1–2 years or <10 years of age at diagnosis. Article in Journal/Newspaper Iceland Wiley Online Library Norway British Journal of Haematology 94 1 82 88 |
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Wiley Online Library |
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English |
description |
From July 1984 the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) have registered all children with acute myeloid leukaemia (AML) and treated them on two consecutive protocols of different intensity (NOPHO‐84 and NOPHO‐88). We probably have information on every child with this diagnosis in our region. We found an annual incidence of AML of 0.7 new cases per 100 000 children <16 years of age. We observed a distinct peak of incidence in the first 2 years of life. Children with Down’s syndrome accounted for 13% of all cases. Eighty of 105 cases treated on NOPHO‐84 achieved remission (78%). In NOPHO‐88, 100/118 patients entered remission (85%). The overall event‐free survival (p‐EFS) for the two studies was 0.32 for NOPHO‐84 and 0.42 for NOPHO‐88. The majority of relapses occurred within 2 years of diagnosis. When looking for prognostic factors the strongest significant adverse factor found was male sex. Children with Down’s syndrome ( n =35) had a very favourable outcome if they received therapy according to protocol, and infants ( n =26) had a superior outcome compared to children 1–2 years or <10 years of age at diagnosis. |
format |
Article in Journal/Newspaper |
author |
Lie, Sverre O. Jonmundsson, Gudmundur Mellander, Lotta Siimes, Martti A. Yssing, Minna G ustafsson, Göran |
spellingShingle |
Lie, Sverre O. Jonmundsson, Gudmundur Mellander, Lotta Siimes, Martti A. Yssing, Minna G ustafsson, Göran A population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome |
author_facet |
Lie, Sverre O. Jonmundsson, Gudmundur Mellander, Lotta Siimes, Martti A. Yssing, Minna G ustafsson, Göran |
author_sort |
Lie, Sverre O. |
title |
A population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome |
title_short |
A population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome |
title_full |
A population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome |
title_fullStr |
A population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome |
title_full_unstemmed |
A population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with Down's syndrome |
title_sort |
population‐based study of 272 children with acute myeloid leukaemia treated on two consecutive protocols with different intensity: best outcome in girls, infants, and children with down's syndrome |
publisher |
Wiley |
publishDate |
1996 |
url |
http://dx.doi.org/10.1046/j.1365-2141.1996.d01-1761.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2141.1996.d01-1761.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2141.1996.d01-1761.x |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
British Journal of Haematology volume 94, issue 1, page 82-88 ISSN 0007-1048 1365-2141 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1046/j.1365-2141.1996.d01-1761.x |
container_title |
British Journal of Haematology |
container_volume |
94 |
container_issue |
1 |
container_start_page |
82 |
op_container_end_page |
88 |
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1800755040035536896 |