The role of Helicobacter pylori urease in the pathogenesis of gastritis and peptic ulceration.

• Published in: Alimentary Pharmacology & Therapeutics
• Main Author: Mobley, HL
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1996
• Subjects: Ure; Carbonic acid
• Online Access: http://dx.doi.org/10.1046/j.1365-2036.1996.22164006.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2036.1996.22164006.x; https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2036.1996.22164006.x

Helicobacter pylori produces a 550 kDa, multimeric, nickel‐containing urease that catalyses the hydrolysis of urea to yield ammonia and carbonic acid. The ure gene cluster, comprised of seven genes, encodes the two structural subunits UreA (26.5 kDa) and UreB (60.3 kDa), and five accessory proteins:...