Obesity and Lowered Cognitive Performance in a Canadian First Nations Population
The association between obesity, other cardiovascular risk factors, and cognitive function in a Canadian First Nations population was investigated using a cross‐sectional design. Eligible individuals were aged ≥18 years, without a history of stroke, nonpregnant, with First Nations status, and who ha...
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crwiley:10.1038/oby.2009.161 2024-09-30T14:35:01+00:00 Obesity and Lowered Cognitive Performance in a Canadian First Nations Population Fergenbaum, Jennifer H. Bruce, Sharon Lou, Wendy Hanley, Anthony J.G. Greenwood, Carol Young, T. Kue 2009 http://dx.doi.org/10.1038/oby.2009.161 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Foby.2009.161 https://onlinelibrary.wiley.com/doi/pdf/10.1038/oby.2009.161 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Obesity volume 17, issue 10, page 1957-1963 ISSN 1930-7381 1930-739X journal-article 2009 crwiley https://doi.org/10.1038/oby.2009.161 2024-09-19T04:18:30Z The association between obesity, other cardiovascular risk factors, and cognitive function in a Canadian First Nations population was investigated using a cross‐sectional design. Eligible individuals were aged ≥18 years, without a history of stroke, nonpregnant, with First Nations status, and who had undergone cognitive function assessment by the Clock Drawing Test (CDT) and Trail Making Test Parts A and B. Parts A and B were combined into an Executive Function Score (TMT‐exec). Hypertension, a previous history of cardiovascular disease, dyslipidemia, metabolic syndrome, insulin resistance, and the presence and duration of diabetes were examined in addition to obesity. In the case of TMT‐exec only, obese individuals were at an approximately fourfold increased risk for lowered cognitive performance compared to those who were not obese in multivariable models (odds ratio (OR): 3.77, 95% confidence interval (CI): 1.46–9.72) whereas there was no effect for overweight individuals compared to those with a normal weight in unadjusted analysis. Those having an increased waist circumference also had 5 times the risk compared to those without an increased waist circumference (OR: 5.41, 95% CI: 1.83–15.99). Adjusted for age, sex, and insulin resistance, individuals having the metabolic syndrome were at an approximately fourfold increased risk compared to those without the metabolic syndrome (OR: 3.67, 95% CI: 1.34–10.07). No other cardiovascular risk factors were associated. Obesity and metabolic syndrome were associated with lowered cognitive performance. These results highlight the importance of studying the health effects of obesity beyond traditional disease endpoints, even in a relatively youthful population. Article in Journal/Newspaper First Nations Wiley Online Library Obesity 17 10 1957 1963 |
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Wiley Online Library |
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English |
description |
The association between obesity, other cardiovascular risk factors, and cognitive function in a Canadian First Nations population was investigated using a cross‐sectional design. Eligible individuals were aged ≥18 years, without a history of stroke, nonpregnant, with First Nations status, and who had undergone cognitive function assessment by the Clock Drawing Test (CDT) and Trail Making Test Parts A and B. Parts A and B were combined into an Executive Function Score (TMT‐exec). Hypertension, a previous history of cardiovascular disease, dyslipidemia, metabolic syndrome, insulin resistance, and the presence and duration of diabetes were examined in addition to obesity. In the case of TMT‐exec only, obese individuals were at an approximately fourfold increased risk for lowered cognitive performance compared to those who were not obese in multivariable models (odds ratio (OR): 3.77, 95% confidence interval (CI): 1.46–9.72) whereas there was no effect for overweight individuals compared to those with a normal weight in unadjusted analysis. Those having an increased waist circumference also had 5 times the risk compared to those without an increased waist circumference (OR: 5.41, 95% CI: 1.83–15.99). Adjusted for age, sex, and insulin resistance, individuals having the metabolic syndrome were at an approximately fourfold increased risk compared to those without the metabolic syndrome (OR: 3.67, 95% CI: 1.34–10.07). No other cardiovascular risk factors were associated. Obesity and metabolic syndrome were associated with lowered cognitive performance. These results highlight the importance of studying the health effects of obesity beyond traditional disease endpoints, even in a relatively youthful population. |
format |
Article in Journal/Newspaper |
author |
Fergenbaum, Jennifer H. Bruce, Sharon Lou, Wendy Hanley, Anthony J.G. Greenwood, Carol Young, T. Kue |
spellingShingle |
Fergenbaum, Jennifer H. Bruce, Sharon Lou, Wendy Hanley, Anthony J.G. Greenwood, Carol Young, T. Kue Obesity and Lowered Cognitive Performance in a Canadian First Nations Population |
author_facet |
Fergenbaum, Jennifer H. Bruce, Sharon Lou, Wendy Hanley, Anthony J.G. Greenwood, Carol Young, T. Kue |
author_sort |
Fergenbaum, Jennifer H. |
title |
Obesity and Lowered Cognitive Performance in a Canadian First Nations Population |
title_short |
Obesity and Lowered Cognitive Performance in a Canadian First Nations Population |
title_full |
Obesity and Lowered Cognitive Performance in a Canadian First Nations Population |
title_fullStr |
Obesity and Lowered Cognitive Performance in a Canadian First Nations Population |
title_full_unstemmed |
Obesity and Lowered Cognitive Performance in a Canadian First Nations Population |
title_sort |
obesity and lowered cognitive performance in a canadian first nations population |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.1038/oby.2009.161 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Foby.2009.161 https://onlinelibrary.wiley.com/doi/pdf/10.1038/oby.2009.161 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Obesity volume 17, issue 10, page 1957-1963 ISSN 1930-7381 1930-739X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1038/oby.2009.161 |
container_title |
Obesity |
container_volume |
17 |
container_issue |
10 |
container_start_page |
1957 |
op_container_end_page |
1963 |
_version_ |
1811638432282181632 |