Telomere Length Is Associated With Obesity Parameters but With a Gender Difference
Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood...
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crwiley:10.1038/oby.2008.413 2024-09-30T14:40:18+00:00 Telomere Length Is Associated With Obesity Parameters but With a Gender Difference Nordfjäll, Katarina Eliasson, Mats Stegmayr, Birgitta Melander, Olle Nilsson, Peter Roos, Göran 2008 http://dx.doi.org/10.1038/oby.2008.413 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Foby.2008.413 https://onlinelibrary.wiley.com/doi/pdf/10.1038/oby.2008.413 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Obesity volume 16, issue 12, page 2682-2689 ISSN 1930-7381 1930-739X journal-article 2008 crwiley https://doi.org/10.1038/oby.2008.413 2024-09-05T05:05:51Z Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood cells on a merged cohort of 989 individuals recruited in the Malmö Diet and Cancer Cohort (MDCC) and the Northern Sweden MONICA project. We found a significant or borderline association between obesity parameters and telomere length in women after age and center adjustments (BMI: r = −0.106, P = 0.021, weight: r = −0.087, P = 0.060, waist circumference: r = −0.099, P = 0.032, hip circumference: r = −0.128, P = 0.005). In men, a positive borderline correlation to high‐density lipoprotein (HDL) ( r = 0.111, P = 0.053) and a negative correlation to 2‐h post‐oral glucose‐tolerance test (OGTT) was observed ( r = −0.202, P = 0.045). In neither group any association was found between telomere length and cholesterol, serum triglycerides, serum low‐density lipoprotein, plasma insulin, blood pressure, pulse pressure, or smoking habits. Our data indicate that telomere length is associated with an “obesity‐phenotype” but only in women. Article in Journal/Newspaper Northern Sweden Wiley Online Library Obesity 16 12 2682 2689 |
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description |
Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood cells on a merged cohort of 989 individuals recruited in the Malmö Diet and Cancer Cohort (MDCC) and the Northern Sweden MONICA project. We found a significant or borderline association between obesity parameters and telomere length in women after age and center adjustments (BMI: r = −0.106, P = 0.021, weight: r = −0.087, P = 0.060, waist circumference: r = −0.099, P = 0.032, hip circumference: r = −0.128, P = 0.005). In men, a positive borderline correlation to high‐density lipoprotein (HDL) ( r = 0.111, P = 0.053) and a negative correlation to 2‐h post‐oral glucose‐tolerance test (OGTT) was observed ( r = −0.202, P = 0.045). In neither group any association was found between telomere length and cholesterol, serum triglycerides, serum low‐density lipoprotein, plasma insulin, blood pressure, pulse pressure, or smoking habits. Our data indicate that telomere length is associated with an “obesity‐phenotype” but only in women. |
format |
Article in Journal/Newspaper |
author |
Nordfjäll, Katarina Eliasson, Mats Stegmayr, Birgitta Melander, Olle Nilsson, Peter Roos, Göran |
spellingShingle |
Nordfjäll, Katarina Eliasson, Mats Stegmayr, Birgitta Melander, Olle Nilsson, Peter Roos, Göran Telomere Length Is Associated With Obesity Parameters but With a Gender Difference |
author_facet |
Nordfjäll, Katarina Eliasson, Mats Stegmayr, Birgitta Melander, Olle Nilsson, Peter Roos, Göran |
author_sort |
Nordfjäll, Katarina |
title |
Telomere Length Is Associated With Obesity Parameters but With a Gender Difference |
title_short |
Telomere Length Is Associated With Obesity Parameters but With a Gender Difference |
title_full |
Telomere Length Is Associated With Obesity Parameters but With a Gender Difference |
title_fullStr |
Telomere Length Is Associated With Obesity Parameters but With a Gender Difference |
title_full_unstemmed |
Telomere Length Is Associated With Obesity Parameters but With a Gender Difference |
title_sort |
telomere length is associated with obesity parameters but with a gender difference |
publisher |
Wiley |
publishDate |
2008 |
url |
http://dx.doi.org/10.1038/oby.2008.413 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Foby.2008.413 https://onlinelibrary.wiley.com/doi/pdf/10.1038/oby.2008.413 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Obesity volume 16, issue 12, page 2682-2689 ISSN 1930-7381 1930-739X |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1038/oby.2008.413 |
container_title |
Obesity |
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16 |
container_issue |
12 |
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2682 |
op_container_end_page |
2689 |
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1811642792957444096 |