Antarctic isolation: Immune and viral studies
Stressful environmental conditions are a major determinant of immune reactivity. This effect is pronounced in Australian National Antarctic Research Expedition populations exposed to prolonged periods of isolation in the Antarctic. Alterations of T cell function, including depression of cutaneous de...
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Online Access: | http://dx.doi.org/10.1038/icb.1997.42 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Ficb.1997.42 http://www.nature.com/articles/icb199742 http://www.nature.com/articles/icb199742.pdf https://onlinelibrary.wiley.com/doi/pdf/10.1038/icb.1997.42 |
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crwiley:10.1038/icb.1997.42 2024-09-09T19:05:44+00:00 Antarctic isolation: Immune and viral studies Tingate, Trevor R Lugg, Desmond J Muller, H Konrad Stowe, Raymond P Pierson, Duane L 1997 http://dx.doi.org/10.1038/icb.1997.42 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Ficb.1997.42 http://www.nature.com/articles/icb199742 http://www.nature.com/articles/icb199742.pdf https://onlinelibrary.wiley.com/doi/pdf/10.1038/icb.1997.42 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Immunology & Cell Biology volume 75, issue 3, page 275-283 ISSN 0818-9641 1440-1711 journal-article 1997 crwiley https://doi.org/10.1038/icb.1997.42 2024-08-27T04:25:21Z Stressful environmental conditions are a major determinant of immune reactivity. This effect is pronounced in Australian National Antarctic Research Expedition populations exposed to prolonged periods of isolation in the Antarctic. Alterations of T cell function, including depression of cutaneous delayed‐type hypersensitivity responses and a peak 48.9% reduction of T cell proliferation to the metogen phytohaemagglutinin, were documented during a 9‐month period of isolation. T cell dysfunction was mediated by changes within the peripheral blood mononuclear cell compartment, including a paradoxical atypical monocytosis associated with altered production of inflammatory cytokines. There was a striking reduction in the production by peripheral blood mononuclear cells of the predominant pro‐inflammatory monokine TNF‐α and changes were also detected in the production of IL‐1, IL‐2, IL‐6. IL‐1ra and IL‐10. Prolonged Antarctic isolation is also associated with altered latent herpesvirus homeostasis, including increased herpesvirus shedding and expansion of the polyclonal latent Epstein‐Barr virus‐infected B cell population. These findings have important long‐term health implications. Article in Journal/Newspaper Antarc* Antarctic Wiley Online Library Antarctic The Antarctic Immunology and Cell Biology 75 3 275 283 |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Stressful environmental conditions are a major determinant of immune reactivity. This effect is pronounced in Australian National Antarctic Research Expedition populations exposed to prolonged periods of isolation in the Antarctic. Alterations of T cell function, including depression of cutaneous delayed‐type hypersensitivity responses and a peak 48.9% reduction of T cell proliferation to the metogen phytohaemagglutinin, were documented during a 9‐month period of isolation. T cell dysfunction was mediated by changes within the peripheral blood mononuclear cell compartment, including a paradoxical atypical monocytosis associated with altered production of inflammatory cytokines. There was a striking reduction in the production by peripheral blood mononuclear cells of the predominant pro‐inflammatory monokine TNF‐α and changes were also detected in the production of IL‐1, IL‐2, IL‐6. IL‐1ra and IL‐10. Prolonged Antarctic isolation is also associated with altered latent herpesvirus homeostasis, including increased herpesvirus shedding and expansion of the polyclonal latent Epstein‐Barr virus‐infected B cell population. These findings have important long‐term health implications. |
format |
Article in Journal/Newspaper |
author |
Tingate, Trevor R Lugg, Desmond J Muller, H Konrad Stowe, Raymond P Pierson, Duane L |
spellingShingle |
Tingate, Trevor R Lugg, Desmond J Muller, H Konrad Stowe, Raymond P Pierson, Duane L Antarctic isolation: Immune and viral studies |
author_facet |
Tingate, Trevor R Lugg, Desmond J Muller, H Konrad Stowe, Raymond P Pierson, Duane L |
author_sort |
Tingate, Trevor R |
title |
Antarctic isolation: Immune and viral studies |
title_short |
Antarctic isolation: Immune and viral studies |
title_full |
Antarctic isolation: Immune and viral studies |
title_fullStr |
Antarctic isolation: Immune and viral studies |
title_full_unstemmed |
Antarctic isolation: Immune and viral studies |
title_sort |
antarctic isolation: immune and viral studies |
publisher |
Wiley |
publishDate |
1997 |
url |
http://dx.doi.org/10.1038/icb.1997.42 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1038%2Ficb.1997.42 http://www.nature.com/articles/icb199742 http://www.nature.com/articles/icb199742.pdf https://onlinelibrary.wiley.com/doi/pdf/10.1038/icb.1997.42 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Immunology & Cell Biology volume 75, issue 3, page 275-283 ISSN 0818-9641 1440-1711 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1038/icb.1997.42 |
container_title |
Immunology and Cell Biology |
container_volume |
75 |
container_issue |
3 |
container_start_page |
275 |
op_container_end_page |
283 |
_version_ |
1809819737981452288 |