Helicobacter pylori antibodies and gastric cancer in Iceland – The decline in IgG antibody level is a risk factor
H. pylori infection is considered a causal agent of duodenal ulcer and a significant risk factor for gastric cancer. Retrospective cohort studies have demonstrated a significant association between presence of antibody to H. pylori and gastric cancer when using samples obtained years before the diag...
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Online Access: | http://dx.doi.org/10.1034/j.1600-0463.2001.091205.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1600-0463.2001.091205.x https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1600-0463.2001.091205.x |
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crwiley:10.1034/j.1600-0463.2001.091205.x 2024-06-02T08:09:19+00:00 Helicobacter pylori antibodies and gastric cancer in Iceland – The decline in IgG antibody level is a risk factor TULINIUS, H. ÖGMUNDSDOTTIR, H. M. KRISTINSSON, K. G. SIGVALDASON, H. SIGVALDADOTTIR, E. KRISTJANSDOTTIR, G. SIGFUSSON, N. 2001 http://dx.doi.org/10.1034/j.1600-0463.2001.091205.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1600-0463.2001.091205.x https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1600-0463.2001.091205.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor APMIS volume 109, issue 12, page 835-841 ISSN 0903-4641 1600-0463 journal-article 2001 crwiley https://doi.org/10.1034/j.1600-0463.2001.091205.x 2024-05-03T10:54:12Z H. pylori infection is considered a causal agent of duodenal ulcer and a significant risk factor for gastric cancer. Retrospective cohort studies have demonstrated a significant association between presence of antibody to H. pylori and gastric cancer when using samples obtained years before the diagnosis but not at the time of diagnosis. The present study investigates, in a population‐based cohort, whether a decline occurs in H. pylori antibody levels before the diagnosis of stomach cancer. Repeat samples (2 to 5) were available from 23 persons with gastric cancer taken up to 20 years before the diagnosis and 128 control subjects matched for gender, age, time and number of repeat samples. The odds ratio of developing stomach cancer was 1.16 (95% CI 1.05–1.28) for those showing decline in antibody levels of 1 relative antibody activity unit per year versus those with constant or rising levels. We conclude that this decline in antibody levels in cases, and not in controls, supports an active role of H. pylori in the pathogenesis of gastric cancer by causing atrophic gastritis, and provides a better risk assessment for gastric cancer compared to single measurements. Article in Journal/Newspaper Iceland Wiley Online Library APMIS 109 12 835 841 |
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Wiley Online Library |
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English |
description |
H. pylori infection is considered a causal agent of duodenal ulcer and a significant risk factor for gastric cancer. Retrospective cohort studies have demonstrated a significant association between presence of antibody to H. pylori and gastric cancer when using samples obtained years before the diagnosis but not at the time of diagnosis. The present study investigates, in a population‐based cohort, whether a decline occurs in H. pylori antibody levels before the diagnosis of stomach cancer. Repeat samples (2 to 5) were available from 23 persons with gastric cancer taken up to 20 years before the diagnosis and 128 control subjects matched for gender, age, time and number of repeat samples. The odds ratio of developing stomach cancer was 1.16 (95% CI 1.05–1.28) for those showing decline in antibody levels of 1 relative antibody activity unit per year versus those with constant or rising levels. We conclude that this decline in antibody levels in cases, and not in controls, supports an active role of H. pylori in the pathogenesis of gastric cancer by causing atrophic gastritis, and provides a better risk assessment for gastric cancer compared to single measurements. |
format |
Article in Journal/Newspaper |
author |
TULINIUS, H. ÖGMUNDSDOTTIR, H. M. KRISTINSSON, K. G. SIGVALDASON, H. SIGVALDADOTTIR, E. KRISTJANSDOTTIR, G. SIGFUSSON, N. |
spellingShingle |
TULINIUS, H. ÖGMUNDSDOTTIR, H. M. KRISTINSSON, K. G. SIGVALDASON, H. SIGVALDADOTTIR, E. KRISTJANSDOTTIR, G. SIGFUSSON, N. Helicobacter pylori antibodies and gastric cancer in Iceland – The decline in IgG antibody level is a risk factor |
author_facet |
TULINIUS, H. ÖGMUNDSDOTTIR, H. M. KRISTINSSON, K. G. SIGVALDASON, H. SIGVALDADOTTIR, E. KRISTJANSDOTTIR, G. SIGFUSSON, N. |
author_sort |
TULINIUS, H. |
title |
Helicobacter pylori antibodies and gastric cancer in Iceland – The decline in IgG antibody level is a risk factor |
title_short |
Helicobacter pylori antibodies and gastric cancer in Iceland – The decline in IgG antibody level is a risk factor |
title_full |
Helicobacter pylori antibodies and gastric cancer in Iceland – The decline in IgG antibody level is a risk factor |
title_fullStr |
Helicobacter pylori antibodies and gastric cancer in Iceland – The decline in IgG antibody level is a risk factor |
title_full_unstemmed |
Helicobacter pylori antibodies and gastric cancer in Iceland – The decline in IgG antibody level is a risk factor |
title_sort |
helicobacter pylori antibodies and gastric cancer in iceland – the decline in igg antibody level is a risk factor |
publisher |
Wiley |
publishDate |
2001 |
url |
http://dx.doi.org/10.1034/j.1600-0463.2001.091205.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1600-0463.2001.091205.x https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1600-0463.2001.091205.x |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
APMIS volume 109, issue 12, page 835-841 ISSN 0903-4641 1600-0463 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1034/j.1600-0463.2001.091205.x |
container_title |
APMIS |
container_volume |
109 |
container_issue |
12 |
container_start_page |
835 |
op_container_end_page |
841 |
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1800755017038168064 |