HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia
Polymerase chain reaction (PCR)‐based genotyping was used to characterize the features of HLA class II molecular polymorphisms in a Slavic population of North‐Western Russia. Two hundred individuals were analyzed for the DRB1 gene, and 100 persons randomly selected from this cohort were additionally...
Published in: | Tissue Antigens |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
1999
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1034/j.1399-0039.1999.540509.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1399-0039.1999.540509.x https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1399-0039.1999.540509.x |
id |
crwiley:10.1034/j.1399-0039.1999.540509.x |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1034/j.1399-0039.1999.540509.x 2024-06-02T08:11:54+00:00 HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia Kapustin, S. Lyshchov, A. Alexandrova, J. Imyanitov, E. Blinov, M. 1999 http://dx.doi.org/10.1034/j.1399-0039.1999.540509.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1399-0039.1999.540509.x https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1399-0039.1999.540509.x en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Tissue Antigens volume 54, issue 5, page 517-520 ISSN 0001-2815 1399-0039 journal-article 1999 crwiley https://doi.org/10.1034/j.1399-0039.1999.540509.x 2024-05-03T11:52:16Z Polymerase chain reaction (PCR)‐based genotyping was used to characterize the features of HLA class II molecular polymorphisms in a Slavic population of North‐Western Russia. Two hundred individuals were analyzed for the DRB1 gene, and 100 persons randomly selected from this cohort were additionally typed for DQA1, DQB1 and DPB1 genes. Allele and haplotype frequencies were found to be similar to those observed in other Caucasian populations, with the exception of considerably high prevalence of the DPB1*0301 allele (16.0%) in the group studied. The high rate of diversity was observed within DRB1*04 and DRB1*14 specificities, as well as for extended DR‐DQ haplotypes. In addition, significant number of “unusual” DR‐DQ linkage patterns have been detected. The data seem to reflect the complexity of ethnic background of “European” Russians and may be helpful for the development of international network between donor registries. Article in Journal/Newspaper North-Western Russia Wiley Online Library Tissue Antigens 54 5 517 520 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Polymerase chain reaction (PCR)‐based genotyping was used to characterize the features of HLA class II molecular polymorphisms in a Slavic population of North‐Western Russia. Two hundred individuals were analyzed for the DRB1 gene, and 100 persons randomly selected from this cohort were additionally typed for DQA1, DQB1 and DPB1 genes. Allele and haplotype frequencies were found to be similar to those observed in other Caucasian populations, with the exception of considerably high prevalence of the DPB1*0301 allele (16.0%) in the group studied. The high rate of diversity was observed within DRB1*04 and DRB1*14 specificities, as well as for extended DR‐DQ haplotypes. In addition, significant number of “unusual” DR‐DQ linkage patterns have been detected. The data seem to reflect the complexity of ethnic background of “European” Russians and may be helpful for the development of international network between donor registries. |
format |
Article in Journal/Newspaper |
author |
Kapustin, S. Lyshchov, A. Alexandrova, J. Imyanitov, E. Blinov, M. |
spellingShingle |
Kapustin, S. Lyshchov, A. Alexandrova, J. Imyanitov, E. Blinov, M. HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia |
author_facet |
Kapustin, S. Lyshchov, A. Alexandrova, J. Imyanitov, E. Blinov, M. |
author_sort |
Kapustin, S. |
title |
HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia |
title_short |
HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia |
title_full |
HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia |
title_fullStr |
HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia |
title_full_unstemmed |
HLA class II molecular polymorphisms in healthy Slavic individuals from North‐Western Russia |
title_sort |
hla class ii molecular polymorphisms in healthy slavic individuals from north‐western russia |
publisher |
Wiley |
publishDate |
1999 |
url |
http://dx.doi.org/10.1034/j.1399-0039.1999.540509.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1034%2Fj.1399-0039.1999.540509.x https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1399-0039.1999.540509.x |
genre |
North-Western Russia |
genre_facet |
North-Western Russia |
op_source |
Tissue Antigens volume 54, issue 5, page 517-520 ISSN 0001-2815 1399-0039 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1034/j.1399-0039.1999.540509.x |
container_title |
Tissue Antigens |
container_volume |
54 |
container_issue |
5 |
container_start_page |
517 |
op_container_end_page |
520 |
_version_ |
1800758179424894976 |