Identification of cDNAs from Japanese pufferfish ( Fugu rubripes) and Atlantic salmon ( Salmo salar) coding for homologues to tetrapod prion proteins
We identified cDNAs coding for homologues to tetrapod prion proteins (PrPs) in Atlantic salmon ( Salmo salar ) and Japanese pufferfish ( Fugu rubripes ), which were termed ‘similar to PrPs’ (stPrPs). Besides significant sequence homologies the fish stPrPs display characteristic structural features i...
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crwiley:10.1016/s0014-5793(03)00149-2 2024-06-23T07:51:14+00:00 Identification of cDNAs from Japanese pufferfish ( Fugu rubripes) and Atlantic salmon ( Salmo salar) coding for homologues to tetrapod prion proteins Oidtmann, Birgit Simon, Dietrich Holtkamp, Nikola Hoffmann, Rudolf Baier, Michael 2003 http://dx.doi.org/10.1016/s0014-5793(03)00149-2 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2803%2900149-2 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(03)00149-2 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2803%2900149-2 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor FEBS Letters volume 538, issue 1-3, page 96-100 ISSN 0014-5793 1873-3468 journal-article 2003 crwiley https://doi.org/10.1016/s0014-5793(03)00149-2 2024-06-04T06:35:04Z We identified cDNAs coding for homologues to tetrapod prion proteins (PrPs) in Atlantic salmon ( Salmo salar ) and Japanese pufferfish ( Fugu rubripes ), which were termed ‘similar to PrPs’ (stPrPs). Besides significant sequence homologies the fish stPrPs display characteristic structural features in common with tetrapod PrPs. In addition, two stPrPs were shown to be highly expressed in brain tissue. None of the so far identified PrP‐homologues of fish resembles doppel. Hence, the duplication of the PrP gene, which generated doppel, may have occurred not in fish but later in the tetrapod lineage. The identification of fish PrPs provides a basis to address concerns about a possible susceptibility of fish to prion infections. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library FEBS Letters 538 1-3 96 100 |
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Open Polar |
collection |
Wiley Online Library |
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crwiley |
language |
English |
description |
We identified cDNAs coding for homologues to tetrapod prion proteins (PrPs) in Atlantic salmon ( Salmo salar ) and Japanese pufferfish ( Fugu rubripes ), which were termed ‘similar to PrPs’ (stPrPs). Besides significant sequence homologies the fish stPrPs display characteristic structural features in common with tetrapod PrPs. In addition, two stPrPs were shown to be highly expressed in brain tissue. None of the so far identified PrP‐homologues of fish resembles doppel. Hence, the duplication of the PrP gene, which generated doppel, may have occurred not in fish but later in the tetrapod lineage. The identification of fish PrPs provides a basis to address concerns about a possible susceptibility of fish to prion infections. |
format |
Article in Journal/Newspaper |
author |
Oidtmann, Birgit Simon, Dietrich Holtkamp, Nikola Hoffmann, Rudolf Baier, Michael |
spellingShingle |
Oidtmann, Birgit Simon, Dietrich Holtkamp, Nikola Hoffmann, Rudolf Baier, Michael Identification of cDNAs from Japanese pufferfish ( Fugu rubripes) and Atlantic salmon ( Salmo salar) coding for homologues to tetrapod prion proteins |
author_facet |
Oidtmann, Birgit Simon, Dietrich Holtkamp, Nikola Hoffmann, Rudolf Baier, Michael |
author_sort |
Oidtmann, Birgit |
title |
Identification of cDNAs from Japanese pufferfish ( Fugu rubripes) and Atlantic salmon ( Salmo salar) coding for homologues to tetrapod prion proteins |
title_short |
Identification of cDNAs from Japanese pufferfish ( Fugu rubripes) and Atlantic salmon ( Salmo salar) coding for homologues to tetrapod prion proteins |
title_full |
Identification of cDNAs from Japanese pufferfish ( Fugu rubripes) and Atlantic salmon ( Salmo salar) coding for homologues to tetrapod prion proteins |
title_fullStr |
Identification of cDNAs from Japanese pufferfish ( Fugu rubripes) and Atlantic salmon ( Salmo salar) coding for homologues to tetrapod prion proteins |
title_full_unstemmed |
Identification of cDNAs from Japanese pufferfish ( Fugu rubripes) and Atlantic salmon ( Salmo salar) coding for homologues to tetrapod prion proteins |
title_sort |
identification of cdnas from japanese pufferfish ( fugu rubripes) and atlantic salmon ( salmo salar) coding for homologues to tetrapod prion proteins |
publisher |
Wiley |
publishDate |
2003 |
url |
http://dx.doi.org/10.1016/s0014-5793(03)00149-2 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2803%2900149-2 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793(03)00149-2 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2803%2900149-2 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
FEBS Letters volume 538, issue 1-3, page 96-100 ISSN 0014-5793 1873-3468 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1016/s0014-5793(03)00149-2 |
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FEBS Letters |
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538 |
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1-3 |
container_start_page |
96 |
op_container_end_page |
100 |
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1802642263096950784 |