Conformation of a T cell stimulating peptide in aqueous solution
Using two‐dimensional NMR spectroscopy and circular dichroism spectroscopy it is demonstrated that a T cell stimulating peptide corresponding to residues 132–153 of sperm whale myoglobin populates helical conformations in aqueous solution. This finding is in accordance with proposals that immunodomi...
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Wiley
1989
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Online Access: | http://dx.doi.org/10.1016/0014-5793(89)80764-1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2889%2980764-1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(89)80764-1 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2889%2980764-1 |
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crwiley:10.1016/0014-5793(89)80764-1 2024-06-02T08:14:52+00:00 Conformation of a T cell stimulating peptide in aqueous solution Waltho, Jonathan P. Feher, Victoria A. Lerner, Richard A. Wright, Peter E. 1989 http://dx.doi.org/10.1016/0014-5793(89)80764-1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2889%2980764-1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(89)80764-1 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2889%2980764-1 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor FEBS Letters volume 250, issue 2, page 400-404 ISSN 0014-5793 1873-3468 journal-article 1989 crwiley https://doi.org/10.1016/0014-5793(89)80764-1 2024-05-03T11:38:08Z Using two‐dimensional NMR spectroscopy and circular dichroism spectroscopy it is demonstrated that a T cell stimulating peptide corresponding to residues 132–153 of sperm whale myoglobin populates helical conformations in aqueous solution. This finding is in accordance with proposals that immunodominant sites in T cell stimulating peptides have a high conformational propensity. The observation of secondary structure in aqueous solutions of this and other immunogenic peptides has important implications for initiation of protein folding. Article in Journal/Newspaper Sperm whale Wiley Online Library FEBS Letters 250 2 400 404 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Using two‐dimensional NMR spectroscopy and circular dichroism spectroscopy it is demonstrated that a T cell stimulating peptide corresponding to residues 132–153 of sperm whale myoglobin populates helical conformations in aqueous solution. This finding is in accordance with proposals that immunodominant sites in T cell stimulating peptides have a high conformational propensity. The observation of secondary structure in aqueous solutions of this and other immunogenic peptides has important implications for initiation of protein folding. |
format |
Article in Journal/Newspaper |
author |
Waltho, Jonathan P. Feher, Victoria A. Lerner, Richard A. Wright, Peter E. |
spellingShingle |
Waltho, Jonathan P. Feher, Victoria A. Lerner, Richard A. Wright, Peter E. Conformation of a T cell stimulating peptide in aqueous solution |
author_facet |
Waltho, Jonathan P. Feher, Victoria A. Lerner, Richard A. Wright, Peter E. |
author_sort |
Waltho, Jonathan P. |
title |
Conformation of a T cell stimulating peptide in aqueous solution |
title_short |
Conformation of a T cell stimulating peptide in aqueous solution |
title_full |
Conformation of a T cell stimulating peptide in aqueous solution |
title_fullStr |
Conformation of a T cell stimulating peptide in aqueous solution |
title_full_unstemmed |
Conformation of a T cell stimulating peptide in aqueous solution |
title_sort |
conformation of a t cell stimulating peptide in aqueous solution |
publisher |
Wiley |
publishDate |
1989 |
url |
http://dx.doi.org/10.1016/0014-5793(89)80764-1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793%2889%2980764-1 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2F0014-5793(89)80764-1 https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2889%2980764-1 |
genre |
Sperm whale |
genre_facet |
Sperm whale |
op_source |
FEBS Letters volume 250, issue 2, page 400-404 ISSN 0014-5793 1873-3468 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1016/0014-5793(89)80764-1 |
container_title |
FEBS Letters |
container_volume |
250 |
container_issue |
2 |
container_start_page |
400 |
op_container_end_page |
404 |
_version_ |
1800738869657731072 |