Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.)
Abstract This study examined the effects of sesamin inclusion in vegetable oil‐based diets fed to Atlantic salmon ( Salmo salar L.). The diets used differed in n‐6/n‐3 fatty acid (FA) ratio (0.5 and 1) and sesamin content (high 5.8 g/kg, low 1.16 g/kg and no sesamin). The oils used in the feeds were...
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crwiley:10.1007/s11745-012-3697-7 2024-06-23T07:51:19+00:00 Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.) Schiller Vestergren, A. Wagner, L. Pickova, J. Rosenlund, G. Kamal‐Eldin, A. Trattner, S. 2012 http://dx.doi.org/10.1007/s11745-012-3697-7 https://onlinelibrary.wiley.com/doi/pdf/10.1007/s11745-012-3697-7 https://onlinelibrary.wiley.com/doi/full-xml/10.1007/s11745-012-3697-7 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Lipids volume 47, issue 9, page 897-911 ISSN 0024-4201 1558-9307 journal-article 2012 crwiley https://doi.org/10.1007/s11745-012-3697-7 2024-06-06T04:20:03Z Abstract This study examined the effects of sesamin inclusion in vegetable oil‐based diets fed to Atlantic salmon ( Salmo salar L.). The diets used differed in n‐6/n‐3 fatty acid (FA) ratio (0.5 and 1) and sesamin content (high 5.8 g/kg, low 1.16 g/kg and no sesamin). The oils used in the feeds were a mixture of rapeseed, linseed and palm oil. Fish were fed for 4 months. Fatty acids and expression of hepatic genes involved in transcription, lipid uptake, desaturation, elongation and β‐oxidation were measured. No major effects on the percentage of DHA in white muscle, liver triacylglycerol and phospholipid fraction were detected. Genes involved in β‐oxidation, elongation and desaturation were affected by sesamin addition. Limited effects were seen on any of the transcription factors tested and no effect was seen on the expression of peroxisome proliferator‐activated receptors (PPAR). Expression of both SREBP‐1 and SREBP‐2 increased with sesamin addition. It was concluded that supplementation of fish feed with a high level of sesamin had a negative effect on the growth rate and live weight and did not alter the proportions of DHA in tissues even though gene expression was affected. Thus, more studies are needed to formulate a diet that would increase the percentage of DHA in fish without negative effects on fish growth. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Lipids 47 9 897 911 |
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English |
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Abstract This study examined the effects of sesamin inclusion in vegetable oil‐based diets fed to Atlantic salmon ( Salmo salar L.). The diets used differed in n‐6/n‐3 fatty acid (FA) ratio (0.5 and 1) and sesamin content (high 5.8 g/kg, low 1.16 g/kg and no sesamin). The oils used in the feeds were a mixture of rapeseed, linseed and palm oil. Fish were fed for 4 months. Fatty acids and expression of hepatic genes involved in transcription, lipid uptake, desaturation, elongation and β‐oxidation were measured. No major effects on the percentage of DHA in white muscle, liver triacylglycerol and phospholipid fraction were detected. Genes involved in β‐oxidation, elongation and desaturation were affected by sesamin addition. Limited effects were seen on any of the transcription factors tested and no effect was seen on the expression of peroxisome proliferator‐activated receptors (PPAR). Expression of both SREBP‐1 and SREBP‐2 increased with sesamin addition. It was concluded that supplementation of fish feed with a high level of sesamin had a negative effect on the growth rate and live weight and did not alter the proportions of DHA in tissues even though gene expression was affected. Thus, more studies are needed to formulate a diet that would increase the percentage of DHA in fish without negative effects on fish growth. |
format |
Article in Journal/Newspaper |
author |
Schiller Vestergren, A. Wagner, L. Pickova, J. Rosenlund, G. Kamal‐Eldin, A. Trattner, S. |
spellingShingle |
Schiller Vestergren, A. Wagner, L. Pickova, J. Rosenlund, G. Kamal‐Eldin, A. Trattner, S. Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.) |
author_facet |
Schiller Vestergren, A. Wagner, L. Pickova, J. Rosenlund, G. Kamal‐Eldin, A. Trattner, S. |
author_sort |
Schiller Vestergren, A. |
title |
Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.) |
title_short |
Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.) |
title_full |
Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.) |
title_fullStr |
Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.) |
title_full_unstemmed |
Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.) |
title_sort |
sesamin modulates gene expression without corresponding effects on fatty acids in atlantic salmon ( salmo salar l.) |
publisher |
Wiley |
publishDate |
2012 |
url |
http://dx.doi.org/10.1007/s11745-012-3697-7 https://onlinelibrary.wiley.com/doi/pdf/10.1007/s11745-012-3697-7 https://onlinelibrary.wiley.com/doi/full-xml/10.1007/s11745-012-3697-7 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Lipids volume 47, issue 9, page 897-911 ISSN 0024-4201 1558-9307 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1007/s11745-012-3697-7 |
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47 |
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9 |
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