Dietary n‐3 HUFA Affects Mitochondrial Fatty Acid β‐Oxidation Capacity and Susceptibility to Oxidative Stress in Atlantic Salmon
Abstract Atlantic salmon ( Salmo salar ) (90 g) were fed four different diets for 21 weeks (final weight 344 g). The levels of n‐3 highly unsaturated fatty acids (HUFA) ranged from 11% of the total fatty acids (FA) in the low n‐3 diet to 21% in the intermediate n‐3 diet, to 55 and 58% in the high n‐...
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crwiley:10.1007/s11745-008-3208-z 2024-10-13T14:06:05+00:00 Dietary n‐3 HUFA Affects Mitochondrial Fatty Acid β‐Oxidation Capacity and Susceptibility to Oxidative Stress in Atlantic Salmon Kjær, M. A. Todorčević, M. Torstensen, B. E. Vegusdal, A. Ruyter, B. Norges Forskningsråd 2008 http://dx.doi.org/10.1007/s11745-008-3208-z https://onlinelibrary.wiley.com/doi/full/10.1007/s11745-008-3208-z en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Lipids volume 43, issue 9, page 813-827 ISSN 0024-4201 1558-9307 journal-article 2008 crwiley https://doi.org/10.1007/s11745-008-3208-z 2024-09-17T04:43:26Z Abstract Atlantic salmon ( Salmo salar ) (90 g) were fed four different diets for 21 weeks (final weight 344 g). The levels of n‐3 highly unsaturated fatty acids (HUFA) ranged from 11% of the total fatty acids (FA) in the low n‐3 diet to 21% in the intermediate n‐3 diet, to 55 and 58% in the high n‐3 diets. The high n‐3 diets were enriched with either docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA). Increasing dietary levels of n‐3 HUFA led to increasing percentages (from 31 to 52%) of these FA in liver lipids. The group fed the highest level of DHA had higher expressions of peroxisome proliferator‐activated receptor (PPAR) β and the FA β‐oxidation genes acyl‐CoA oxidase (ACO) and carnitine palmitoyltransferase (CPT)‐II, compared to the low n‐3 groups. The high n‐3 groups had reduced activity of mitochondrial cytochrome c oxidase and β‐oxidation capacity, together with increased activities of superoxide dismutase (SOD) and caspase‐3 activities. In the group fed the highest level of n‐3 HUFA, decreased percentages of major phospholipids (PL) in the mitochondrial and microsomal membranes of the liver were also apparent. The percentage of mitochondrial cardiolipin (Ptd 2 Gro) was 3.1 in the highest n‐3 group compared to 6.6 in the intermediate group. These data clearly show an increased incidence of oxidative stress in the liver of fish fed the high n‐3 diets. Article in Journal/Newspaper Atlantic salmon Salmo salar Wiley Online Library Lipids 43 9 813 827 |
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Wiley Online Library |
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English |
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Abstract Atlantic salmon ( Salmo salar ) (90 g) were fed four different diets for 21 weeks (final weight 344 g). The levels of n‐3 highly unsaturated fatty acids (HUFA) ranged from 11% of the total fatty acids (FA) in the low n‐3 diet to 21% in the intermediate n‐3 diet, to 55 and 58% in the high n‐3 diets. The high n‐3 diets were enriched with either docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA). Increasing dietary levels of n‐3 HUFA led to increasing percentages (from 31 to 52%) of these FA in liver lipids. The group fed the highest level of DHA had higher expressions of peroxisome proliferator‐activated receptor (PPAR) β and the FA β‐oxidation genes acyl‐CoA oxidase (ACO) and carnitine palmitoyltransferase (CPT)‐II, compared to the low n‐3 groups. The high n‐3 groups had reduced activity of mitochondrial cytochrome c oxidase and β‐oxidation capacity, together with increased activities of superoxide dismutase (SOD) and caspase‐3 activities. In the group fed the highest level of n‐3 HUFA, decreased percentages of major phospholipids (PL) in the mitochondrial and microsomal membranes of the liver were also apparent. The percentage of mitochondrial cardiolipin (Ptd 2 Gro) was 3.1 in the highest n‐3 group compared to 6.6 in the intermediate group. These data clearly show an increased incidence of oxidative stress in the liver of fish fed the high n‐3 diets. |
author2 |
Norges Forskningsråd |
format |
Article in Journal/Newspaper |
author |
Kjær, M. A. Todorčević, M. Torstensen, B. E. Vegusdal, A. Ruyter, B. |
spellingShingle |
Kjær, M. A. Todorčević, M. Torstensen, B. E. Vegusdal, A. Ruyter, B. Dietary n‐3 HUFA Affects Mitochondrial Fatty Acid β‐Oxidation Capacity and Susceptibility to Oxidative Stress in Atlantic Salmon |
author_facet |
Kjær, M. A. Todorčević, M. Torstensen, B. E. Vegusdal, A. Ruyter, B. |
author_sort |
Kjær, M. A. |
title |
Dietary n‐3 HUFA Affects Mitochondrial Fatty Acid β‐Oxidation Capacity and Susceptibility to Oxidative Stress in Atlantic Salmon |
title_short |
Dietary n‐3 HUFA Affects Mitochondrial Fatty Acid β‐Oxidation Capacity and Susceptibility to Oxidative Stress in Atlantic Salmon |
title_full |
Dietary n‐3 HUFA Affects Mitochondrial Fatty Acid β‐Oxidation Capacity and Susceptibility to Oxidative Stress in Atlantic Salmon |
title_fullStr |
Dietary n‐3 HUFA Affects Mitochondrial Fatty Acid β‐Oxidation Capacity and Susceptibility to Oxidative Stress in Atlantic Salmon |
title_full_unstemmed |
Dietary n‐3 HUFA Affects Mitochondrial Fatty Acid β‐Oxidation Capacity and Susceptibility to Oxidative Stress in Atlantic Salmon |
title_sort |
dietary n‐3 hufa affects mitochondrial fatty acid β‐oxidation capacity and susceptibility to oxidative stress in atlantic salmon |
publisher |
Wiley |
publishDate |
2008 |
url |
http://dx.doi.org/10.1007/s11745-008-3208-z https://onlinelibrary.wiley.com/doi/full/10.1007/s11745-008-3208-z |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Lipids volume 43, issue 9, page 813-827 ISSN 0024-4201 1558-9307 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1007/s11745-008-3208-z |
container_title |
Lipids |
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43 |
container_issue |
9 |
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813 |
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827 |
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1812812130531934208 |