Effect of marine oils supplementation on coagulation and cellular activation in whole blood
Abstract A study was performed to explore the effects of supplemental intake of various marine oils known to be part of the Eskimo diet. Healthy men and women (134) were randomly selected to consume 15 mL/d of oil from blubber of seal, cod liver, seal/cod liver, blubber of Minke whale, or no oil for...
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crwiley:10.1007/bf02536611 2023-12-03T10:22:16+01:00 Effect of marine oils supplementation on coagulation and cellular activation in whole blood Østerud, Bjarne Elvevoll, Edel Barstad, Harald Brox, Jan Halvorsen, Hanne Lia, Karin Olsen, Jan Ole Olsen, Ragnar L. Sissener, Charlotte Rekdal, Øystein Vognild, Eva 1995 http://dx.doi.org/10.1007/bf02536611 https://onlinelibrary.wiley.com/doi/full/10.1007/BF02536611 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Lipids volume 30, issue 12, page 1111-1118 ISSN 0024-4201 1558-9307 Cell Biology Organic Chemistry Biochemistry journal-article 1995 crwiley https://doi.org/10.1007/bf02536611 2023-11-09T14:35:45Z Abstract A study was performed to explore the effects of supplemental intake of various marine oils known to be part of the Eskimo diet. Healthy men and women (134) were randomly selected to consume 15 mL/d of oil from blubber of seal, cod liver, seal/cod liver, blubber of Minke whale, or no oil for ten weeks. Total cholesterol was unchanged in the oil groups, whereas high density lipoprotein cholesterol increased 7% in the seal/cod liver oil (CLO) group ( P <0.05) and 11% in the whale oil group ( P <0.005). Triacylglycerol was significantly reduced in the CLO group only. The concentration of prothrombin fragment 1+2 was reduced 25% ( P <0.05) after whale oil supplementation. No change in fibrinogen or factor VIIc was detected. Tumor necrosis factor generation in lipopolysaccharide (LPS)‐stimulated blood was 30% reduced after whale oil ( P <0.05), but was unaffected by intake of seal or CLO. The LPS‐induced tissue factor activity in monocytes was reduced to a significant degree only in the seal/CLO group (34%) and whale oil group (35%) ( P <0.05). The most dramatic change in thromboxane B 2 in LPS‐stimulated blood was seen after whale oil intake with 44% reduction ( P <0.01). Supplementation of a regular diet with a combination of seal oil and CLO and especially with whale oil seems to have beneficial effects on several products thought to be associated with cardiovascular and thrombotic diseases. Article in Journal/Newspaper eskimo* minke whale Wiley Online Library (via Crossref) Lipids 30 12 1111 1118 |
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Open Polar |
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Wiley Online Library (via Crossref) |
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language |
English |
topic |
Cell Biology Organic Chemistry Biochemistry |
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Cell Biology Organic Chemistry Biochemistry Østerud, Bjarne Elvevoll, Edel Barstad, Harald Brox, Jan Halvorsen, Hanne Lia, Karin Olsen, Jan Ole Olsen, Ragnar L. Sissener, Charlotte Rekdal, Øystein Vognild, Eva Effect of marine oils supplementation on coagulation and cellular activation in whole blood |
topic_facet |
Cell Biology Organic Chemistry Biochemistry |
description |
Abstract A study was performed to explore the effects of supplemental intake of various marine oils known to be part of the Eskimo diet. Healthy men and women (134) were randomly selected to consume 15 mL/d of oil from blubber of seal, cod liver, seal/cod liver, blubber of Minke whale, or no oil for ten weeks. Total cholesterol was unchanged in the oil groups, whereas high density lipoprotein cholesterol increased 7% in the seal/cod liver oil (CLO) group ( P <0.05) and 11% in the whale oil group ( P <0.005). Triacylglycerol was significantly reduced in the CLO group only. The concentration of prothrombin fragment 1+2 was reduced 25% ( P <0.05) after whale oil supplementation. No change in fibrinogen or factor VIIc was detected. Tumor necrosis factor generation in lipopolysaccharide (LPS)‐stimulated blood was 30% reduced after whale oil ( P <0.05), but was unaffected by intake of seal or CLO. The LPS‐induced tissue factor activity in monocytes was reduced to a significant degree only in the seal/CLO group (34%) and whale oil group (35%) ( P <0.05). The most dramatic change in thromboxane B 2 in LPS‐stimulated blood was seen after whale oil intake with 44% reduction ( P <0.01). Supplementation of a regular diet with a combination of seal oil and CLO and especially with whale oil seems to have beneficial effects on several products thought to be associated with cardiovascular and thrombotic diseases. |
format |
Article in Journal/Newspaper |
author |
Østerud, Bjarne Elvevoll, Edel Barstad, Harald Brox, Jan Halvorsen, Hanne Lia, Karin Olsen, Jan Ole Olsen, Ragnar L. Sissener, Charlotte Rekdal, Øystein Vognild, Eva |
author_facet |
Østerud, Bjarne Elvevoll, Edel Barstad, Harald Brox, Jan Halvorsen, Hanne Lia, Karin Olsen, Jan Ole Olsen, Ragnar L. Sissener, Charlotte Rekdal, Øystein Vognild, Eva |
author_sort |
Østerud, Bjarne |
title |
Effect of marine oils supplementation on coagulation and cellular activation in whole blood |
title_short |
Effect of marine oils supplementation on coagulation and cellular activation in whole blood |
title_full |
Effect of marine oils supplementation on coagulation and cellular activation in whole blood |
title_fullStr |
Effect of marine oils supplementation on coagulation and cellular activation in whole blood |
title_full_unstemmed |
Effect of marine oils supplementation on coagulation and cellular activation in whole blood |
title_sort |
effect of marine oils supplementation on coagulation and cellular activation in whole blood |
publisher |
Wiley |
publishDate |
1995 |
url |
http://dx.doi.org/10.1007/bf02536611 https://onlinelibrary.wiley.com/doi/full/10.1007/BF02536611 |
genre |
eskimo* minke whale |
genre_facet |
eskimo* minke whale |
op_source |
Lipids volume 30, issue 12, page 1111-1118 ISSN 0024-4201 1558-9307 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1007/bf02536611 |
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Lipids |
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30 |
container_issue |
12 |
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1111 |
op_container_end_page |
1118 |
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1784270130325225472 |