The role of arginines in stabilizing the active open‐lid conformation of Rhizomucor miehei lipase

• Published in: Lipids
• Main Authors: Holmquist, Mats, Norin, Martin, Hult, Karl
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1993
• Subjects: Rugosa; Antarc*; Antarctica
• Online Access: http://dx.doi.org/10.1007/bf02535993; https://onlinelibrary.wiley.com/doi/full/10.1007/BF02535993

Abstract Molecular dynamics simulations for the lid covering the active site of Rhizomucor miehei lipase [EC 3.1.1.3] postulated that, among other interactions, Arg86 in the lid stabilized the open‐lid conformation of the protein by multiple hydrogen bonding to the protein surface. Chemical modifica...