Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism
Integrating multifactor blood analysis is a key step toward a precise diagnosis of the health status of marine mammals. Variations in the circulating lipid profile reflect changes in the metabolism and physiology of an individual. To demonstrate the practicability of lipid profiling for physiologica...
Published in: | Zoo Biology |
---|---|
Main Authors: | , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2018
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1002/zoo.21452 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fzoo.21452 https://onlinelibrary.wiley.com/doi/pdf/10.1002/zoo.21452 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/zoo.21452 |
id |
crwiley:10.1002/zoo.21452 |
---|---|
record_format |
openpolar |
spelling |
crwiley:10.1002/zoo.21452 2024-09-15T17:59:02+00:00 Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism Tang, Chuan‐Ho Lin, Ching‐Yu Tsai, Yi‐Lun Lee, Shu‐Hui Wang, Wei‐Hsien Ministry of Science and Technology 2018 http://dx.doi.org/10.1002/zoo.21452 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fzoo.21452 https://onlinelibrary.wiley.com/doi/pdf/10.1002/zoo.21452 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/zoo.21452 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Zoo Biology volume 37, issue 6, page 440-451 ISSN 0733-3188 1098-2361 journal-article 2018 crwiley https://doi.org/10.1002/zoo.21452 2024-08-30T04:10:43Z Integrating multifactor blood analysis is a key step toward a precise diagnosis of the health status of marine mammals. Variations in the circulating lipid profile reflect changes in the metabolism and physiology of an individual. To demonstrate the practicability of lipid profiling for physiological assessment, the phosphorylcholine‐containing lipids in the plasma of long‐term managed beluga whales ( Delphinapterus leucas ) were profiled using a lipidomics methodology. Using a multivariate analysis, the mean corpuscular volume, cholesterol, potassium, and γ‐glutamyltranspeptidase levels were well modeled with the lipid profile of the female whales. In the models, the correlated lipids provided information about blood parameter‐related metabolism and physiological regulation, in particular relating to cholesterol and inflammation. In the males, the levels of cholesterol, triglycerides, blood urea nitrogen, creatinine, plasma iron, and segmented neutrophil were well modeled with the lipid profile. In addition to providing information about the related metabolism and regulation, through a cross‐linked analysis of the blood parameters, the correlated lipids indicated a parallel regulation involved in the energy metabolism of the male whales. Lipidomics as a method for revealing the context of physiological change shows practical potential for the health care of managed whales. Article in Journal/Newspaper Beluga Beluga* Delphinapterus leucas Wiley Online Library Zoo Biology 37 6 440 451 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Integrating multifactor blood analysis is a key step toward a precise diagnosis of the health status of marine mammals. Variations in the circulating lipid profile reflect changes in the metabolism and physiology of an individual. To demonstrate the practicability of lipid profiling for physiological assessment, the phosphorylcholine‐containing lipids in the plasma of long‐term managed beluga whales ( Delphinapterus leucas ) were profiled using a lipidomics methodology. Using a multivariate analysis, the mean corpuscular volume, cholesterol, potassium, and γ‐glutamyltranspeptidase levels were well modeled with the lipid profile of the female whales. In the models, the correlated lipids provided information about blood parameter‐related metabolism and physiological regulation, in particular relating to cholesterol and inflammation. In the males, the levels of cholesterol, triglycerides, blood urea nitrogen, creatinine, plasma iron, and segmented neutrophil were well modeled with the lipid profile. In addition to providing information about the related metabolism and regulation, through a cross‐linked analysis of the blood parameters, the correlated lipids indicated a parallel regulation involved in the energy metabolism of the male whales. Lipidomics as a method for revealing the context of physiological change shows practical potential for the health care of managed whales. |
author2 |
Ministry of Science and Technology |
format |
Article in Journal/Newspaper |
author |
Tang, Chuan‐Ho Lin, Ching‐Yu Tsai, Yi‐Lun Lee, Shu‐Hui Wang, Wei‐Hsien |
spellingShingle |
Tang, Chuan‐Ho Lin, Ching‐Yu Tsai, Yi‐Lun Lee, Shu‐Hui Wang, Wei‐Hsien Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism |
author_facet |
Tang, Chuan‐Ho Lin, Ching‐Yu Tsai, Yi‐Lun Lee, Shu‐Hui Wang, Wei‐Hsien |
author_sort |
Tang, Chuan‐Ho |
title |
Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism |
title_short |
Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism |
title_full |
Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism |
title_fullStr |
Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism |
title_full_unstemmed |
Lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: A correlation study of systemic metabolism |
title_sort |
lipidomics as a diagnostic tool of the metabolic and physiological state of managed whales: a correlation study of systemic metabolism |
publisher |
Wiley |
publishDate |
2018 |
url |
http://dx.doi.org/10.1002/zoo.21452 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fzoo.21452 https://onlinelibrary.wiley.com/doi/pdf/10.1002/zoo.21452 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/zoo.21452 |
genre |
Beluga Beluga* Delphinapterus leucas |
genre_facet |
Beluga Beluga* Delphinapterus leucas |
op_source |
Zoo Biology volume 37, issue 6, page 440-451 ISSN 0733-3188 1098-2361 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/zoo.21452 |
container_title |
Zoo Biology |
container_volume |
37 |
container_issue |
6 |
container_start_page |
440 |
op_container_end_page |
451 |
_version_ |
1810435984597188608 |