Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( Canis lupus)
Abstract A 14‐year‐old male grey wolf ( Canis lupus ) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosi...
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crwiley:10.1002/vms3.909 2024-06-02T08:04:53+00:00 Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( Canis lupus) Yang, Myeon‐Sik Yun, Hyejin Lee, Ki Chang Lim, Chae Woong Kim, Bumseok 2022 http://dx.doi.org/10.1002/vms3.909 https://onlinelibrary.wiley.com/doi/pdf/10.1002/vms3.909 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/vms3.909 en eng Wiley http://creativecommons.org/licenses/by/4.0/ Veterinary Medicine and Science volume 8, issue 6, page 2678-2682 ISSN 2053-1095 2053-1095 journal-article 2022 crwiley https://doi.org/10.1002/vms3.909 2024-05-03T12:04:43Z Abstract A 14‐year‐old male grey wolf ( Canis lupus ) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis were observed in the nasal turbinate. Microscopic examination revealed a tumour principally composed of obvious clear tumour cells characterised by small hyperchromatic nuclei and abundant clear cytoplasm. These clear cells were positive for mucin with PAS, PAS‐D reaction, and alcian blue (pH 2.5) staining, but negative for PTAH staining. Immunohistochemically, some of tumour cells were strongly positive for mesenchymal cells (vimentin), whereas they were negative for myoepithelial antigen (alpha‐SMA) and cytokeratin. Based on the histopathological and immunohistochemical features, the present case was diagnosed as high‐grade clear cell variant mucoepidermoid carcinoma (MEC). This is the first description of clear cell variant MEC in a wolf. Article in Journal/Newspaper Canis lupus Wiley Online Library Veterinary Medicine and Science |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract A 14‐year‐old male grey wolf ( Canis lupus ) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis were observed in the nasal turbinate. Microscopic examination revealed a tumour principally composed of obvious clear tumour cells characterised by small hyperchromatic nuclei and abundant clear cytoplasm. These clear cells were positive for mucin with PAS, PAS‐D reaction, and alcian blue (pH 2.5) staining, but negative for PTAH staining. Immunohistochemically, some of tumour cells were strongly positive for mesenchymal cells (vimentin), whereas they were negative for myoepithelial antigen (alpha‐SMA) and cytokeratin. Based on the histopathological and immunohistochemical features, the present case was diagnosed as high‐grade clear cell variant mucoepidermoid carcinoma (MEC). This is the first description of clear cell variant MEC in a wolf. |
format |
Article in Journal/Newspaper |
author |
Yang, Myeon‐Sik Yun, Hyejin Lee, Ki Chang Lim, Chae Woong Kim, Bumseok |
spellingShingle |
Yang, Myeon‐Sik Yun, Hyejin Lee, Ki Chang Lim, Chae Woong Kim, Bumseok Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( Canis lupus) |
author_facet |
Yang, Myeon‐Sik Yun, Hyejin Lee, Ki Chang Lim, Chae Woong Kim, Bumseok |
author_sort |
Yang, Myeon‐Sik |
title |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( Canis lupus) |
title_short |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( Canis lupus) |
title_full |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( Canis lupus) |
title_fullStr |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( Canis lupus) |
title_full_unstemmed |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( Canis lupus) |
title_sort |
clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf ( canis lupus) |
publisher |
Wiley |
publishDate |
2022 |
url |
http://dx.doi.org/10.1002/vms3.909 https://onlinelibrary.wiley.com/doi/pdf/10.1002/vms3.909 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/vms3.909 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Veterinary Medicine and Science volume 8, issue 6, page 2678-2682 ISSN 2053-1095 2053-1095 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1002/vms3.909 |
container_title |
Veterinary Medicine and Science |
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1800749574131810304 |