Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process
Abstract An analysis of an out‐of‐equilibrium cyclic reaction network which continuously converts a minor undesired product enantiomer to the desired major enantiomer by irreversible addition of chemical fuel and irreversible elimination of spent fuel is presented. The reaction network is maintained...
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crwiley:10.1002/syst.202300045 2024-06-02T08:05:12+00:00 Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process Margarita, Cristiana Nash, Anna Laurell Ahlstrand, David A. Ahlquist, Mårten S. G. Wendt, Ola F. Fransson, Linda Moberg, Christina Vetenskapsrådet Kungliga Tekniska Högskolan 2023 http://dx.doi.org/10.1002/syst.202300045 en eng Wiley http://creativecommons.org/licenses/by-nc-nd/4.0/ ChemSystemsChem volume 6, issue 2 ISSN 2570-4206 2570-4206 journal-article 2023 crwiley https://doi.org/10.1002/syst.202300045 2024-05-03T11:14:21Z Abstract An analysis of an out‐of‐equilibrium cyclic reaction network which continuously converts a minor undesired product enantiomer to the desired major enantiomer by irreversible addition of chemical fuel and irreversible elimination of spent fuel is presented. The reaction network is maintained as long as fuel is added; interrupted fuel addition drives the system towards equilibrium, but the cyclic process restarts upon resumed fuel addition, as demonstrated by three consecutive fuel cycles. The process is powered by the hydrolysis of methyl cyanoformate to HCN and monomethyl carbonic acid, which decomposes to CO 2 and MeOH. The time it takes to reach steady state depends on the rate of conversion of the fuel and decreases with increased conversion rate. Three catalysts, one metal catalyst and two enzymes, together constitute an efficient regulation system allowing control of the forward, backward and waste‐forming steps, thereby assuring the production of high yields of products with high enantiopurity. Article in Journal/Newspaper Carbonic acid Wiley Online Library ChemSystemsChem 6 2 |
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Wiley Online Library |
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English |
description |
Abstract An analysis of an out‐of‐equilibrium cyclic reaction network which continuously converts a minor undesired product enantiomer to the desired major enantiomer by irreversible addition of chemical fuel and irreversible elimination of spent fuel is presented. The reaction network is maintained as long as fuel is added; interrupted fuel addition drives the system towards equilibrium, but the cyclic process restarts upon resumed fuel addition, as demonstrated by three consecutive fuel cycles. The process is powered by the hydrolysis of methyl cyanoformate to HCN and monomethyl carbonic acid, which decomposes to CO 2 and MeOH. The time it takes to reach steady state depends on the rate of conversion of the fuel and decreases with increased conversion rate. Three catalysts, one metal catalyst and two enzymes, together constitute an efficient regulation system allowing control of the forward, backward and waste‐forming steps, thereby assuring the production of high yields of products with high enantiopurity. |
author2 |
Vetenskapsrådet Kungliga Tekniska Högskolan |
format |
Article in Journal/Newspaper |
author |
Margarita, Cristiana Nash, Anna Laurell Ahlstrand, David A. Ahlquist, Mårten S. G. Wendt, Ola F. Fransson, Linda Moberg, Christina |
spellingShingle |
Margarita, Cristiana Nash, Anna Laurell Ahlstrand, David A. Ahlquist, Mårten S. G. Wendt, Ola F. Fransson, Linda Moberg, Christina Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process |
author_facet |
Margarita, Cristiana Nash, Anna Laurell Ahlstrand, David A. Ahlquist, Mårten S. G. Wendt, Ola F. Fransson, Linda Moberg, Christina |
author_sort |
Margarita, Cristiana |
title |
Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_short |
Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_full |
Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_fullStr |
Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_full_unstemmed |
Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process |
title_sort |
dissipative cyclic reaction networks: mechanistic insights into a minor enantiomer recycling process |
publisher |
Wiley |
publishDate |
2023 |
url |
http://dx.doi.org/10.1002/syst.202300045 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
ChemSystemsChem volume 6, issue 2 ISSN 2570-4206 2570-4206 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1002/syst.202300045 |
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ChemSystemsChem |
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6 |
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2 |
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1800749977382682624 |