Simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples
Abstract Bromodiphenyl ethers (BDEs) are a class of synthetic flame retardants and are widely present in the environment. Analysis of higher BDE congeners has proven to be a challenge. We report the development of a method that enhances their analysis by splitting the eluent of a gas chromatograph (...
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crwiley:10.1002/rcm.3410 2024-06-02T08:07:46+00:00 Simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples Wang, Dongli Atkinson, Shannon Hoover‐Miller, Anne Shelver, Weilin L. Li, Qing X. 2008 http://dx.doi.org/10.1002/rcm.3410 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Frcm.3410 https://onlinelibrary.wiley.com/doi/full/10.1002/rcm.3410 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Rapid Communications in Mass Spectrometry volume 22, issue 5, page 647-656 ISSN 0951-4198 1097-0231 journal-article 2008 crwiley https://doi.org/10.1002/rcm.3410 2024-05-03T11:25:47Z Abstract Bromodiphenyl ethers (BDEs) are a class of synthetic flame retardants and are widely present in the environment. Analysis of higher BDE congeners has proven to be a challenge. We report the development of a method that enhances their analysis by splitting the eluent of a gas chromatograph (GC) between an electron capture detector (ECD) and an ion trap mass spectrometer (ITMS): 1:10, ECD:ITMS. This allowed the quantitation of the lower molecular weight (MW) BDE congeners (Br 1 –Br 7 ) with the ITMS and of the higher MW BDEs (Br 8 –Br 10 ) with the highly sensitive ECD. The IT temperature, ionization mode, and MS/MS parameters (excitation amplitude and stability parameter) were optimized. This method took the advantages of the best detector for the different BDE homologues and was suitable for the analysis of BDEs in environmental and biological samples. Average recoveries were 52–112% for BDEs from spiked sand samples and 57–126% from spiked lard samples after accelerated solvent extraction followed by silica gel and alumina column clean‐up. Average recoveries ranged from 51% to 130% for 13 C‐labeled BDEs spiked in the real and in matrix samples. The method detection limits for specific congeners were 0.18–120 pg/g of the BDEs in animal tissue samples, and 0.05–40 pg/g in soil and indoor dust samples. The utility of the method was demonstrated by analyzing actual harbor seal blubber, indoor dust and soil samples. The concentration of each BDE ranged from non‐detectable (nd) to 41 ng/g in the dry soil sample, nd to 1042 ng/g in the indoor dust, nd to 15 ng/g wet weight in the Alaskan harbor seal blubber sample, and 0.02 to 11 ng/µL of the identified 23 of the 42 breakdown products from BDE‐209 after zerovalent iron treatment. Finally, an interlaboratory comparison showed high correspondence between the GC/ITMS‐ECD method and a GC high‐resolution MS system for the analysis of BDEs in soil samples. Copyright © 2008 John Wiley & Sons, Ltd. Article in Journal/Newspaper harbor seal Wiley Online Library Rapid Communications in Mass Spectrometry 22 5 647 656 |
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Abstract Bromodiphenyl ethers (BDEs) are a class of synthetic flame retardants and are widely present in the environment. Analysis of higher BDE congeners has proven to be a challenge. We report the development of a method that enhances their analysis by splitting the eluent of a gas chromatograph (GC) between an electron capture detector (ECD) and an ion trap mass spectrometer (ITMS): 1:10, ECD:ITMS. This allowed the quantitation of the lower molecular weight (MW) BDE congeners (Br 1 –Br 7 ) with the ITMS and of the higher MW BDEs (Br 8 –Br 10 ) with the highly sensitive ECD. The IT temperature, ionization mode, and MS/MS parameters (excitation amplitude and stability parameter) were optimized. This method took the advantages of the best detector for the different BDE homologues and was suitable for the analysis of BDEs in environmental and biological samples. Average recoveries were 52–112% for BDEs from spiked sand samples and 57–126% from spiked lard samples after accelerated solvent extraction followed by silica gel and alumina column clean‐up. Average recoveries ranged from 51% to 130% for 13 C‐labeled BDEs spiked in the real and in matrix samples. The method detection limits for specific congeners were 0.18–120 pg/g of the BDEs in animal tissue samples, and 0.05–40 pg/g in soil and indoor dust samples. The utility of the method was demonstrated by analyzing actual harbor seal blubber, indoor dust and soil samples. The concentration of each BDE ranged from non‐detectable (nd) to 41 ng/g in the dry soil sample, nd to 1042 ng/g in the indoor dust, nd to 15 ng/g wet weight in the Alaskan harbor seal blubber sample, and 0.02 to 11 ng/µL of the identified 23 of the 42 breakdown products from BDE‐209 after zerovalent iron treatment. Finally, an interlaboratory comparison showed high correspondence between the GC/ITMS‐ECD method and a GC high‐resolution MS system for the analysis of BDEs in soil samples. Copyright © 2008 John Wiley & Sons, Ltd. |
format |
Article in Journal/Newspaper |
author |
Wang, Dongli Atkinson, Shannon Hoover‐Miller, Anne Shelver, Weilin L. Li, Qing X. |
spellingShingle |
Wang, Dongli Atkinson, Shannon Hoover‐Miller, Anne Shelver, Weilin L. Li, Qing X. Simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples |
author_facet |
Wang, Dongli Atkinson, Shannon Hoover‐Miller, Anne Shelver, Weilin L. Li, Qing X. |
author_sort |
Wang, Dongli |
title |
Simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples |
title_short |
Simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples |
title_full |
Simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples |
title_fullStr |
Simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples |
title_full_unstemmed |
Simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples |
title_sort |
simultaneous use of gas chromatography/ion trap mass spectrometry ‐ electron capture detection to improve the analysis of bromodiphenyl ethers in biological and environmental samples |
publisher |
Wiley |
publishDate |
2008 |
url |
http://dx.doi.org/10.1002/rcm.3410 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Frcm.3410 https://onlinelibrary.wiley.com/doi/full/10.1002/rcm.3410 |
genre |
harbor seal |
genre_facet |
harbor seal |
op_source |
Rapid Communications in Mass Spectrometry volume 22, issue 5, page 647-656 ISSN 0951-4198 1097-0231 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/rcm.3410 |
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Rapid Communications in Mass Spectrometry |
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22 |
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5 |
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647 |
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656 |
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1800752890905624576 |