Cancer‐preventive activities of secondary metabolites from leaves of the bilberry Vaccinium smallii A. Gray

• Published in: Phytotherapy Research
• Main Authors: Mechikova, G. Ya., Kuzmich, A. S., Ponomarenko, L. P., Kalinovsky, A. I., Stepanova, T. A., Fedorov, S. N., Stonik, V. A.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2010
• Subjects: Sakhalin
• Online Access: http://dx.doi.org/10.1002/ptr.3282; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fptr.3282; https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.3282

Abstract Ten secondary metabolites including flavonoids (1–8), caffeic (9) and chlorogenic (10) acids were structurally identified from the extract of Sakhalin bilberry Vaccinium smallii leaves and studied in vitro as potential cancer‐preventive agents. The results showed that compounds 1–10 inhibited EGF‐induced neoplastic transformation of mouse JB6 Cl 41 P + cells in soft agar with an inhibition concentration (INCC 50 ) of 20–80 µ m . Moreover, all these natural products were non‐toxic against JB6 Cl 41 P + cells up to a concentration of 200 µ m . Copyright © 2010 John Wiley & Sons, Ltd.