Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis
Abstract With tuberculosis the leading bacterial killer worldwide and other mycobacterial diseases on the increase, the search for new antimycobacterial agents is timely. In this study, extracts from plants, lichens and fungal endophytes of Scottish provenance were screened for activity against Myco...
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crwiley:10.1002/ptr.2988 2024-06-23T07:52:31+00:00 Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis Gordien, Andréa Y. Gray, Alexander I. Ingleby, Kevin Franzblau, Scott G. Seidel, Véronique EPSRC 2009 http://dx.doi.org/10.1002/ptr.2988 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fptr.2988 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.2988 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Phytotherapy Research volume 24, issue 5, page 692-698 ISSN 0951-418X 1099-1573 journal-article 2009 crwiley https://doi.org/10.1002/ptr.2988 2024-06-11T04:48:29Z Abstract With tuberculosis the leading bacterial killer worldwide and other mycobacterial diseases on the increase, the search for new antimycobacterial agents is timely. In this study, extracts from plants, lichens and fungal endophytes of Scottish provenance were screened for activity against Mycobacterium aurum and M. tuberculosis H 37 Rv. The best activity against M. aurum was observed for extracts of Juniperus communis roots and Cladonia arbuscula (MIC = 4 µg/mL), and a fungal endophyte isolated from Vaccinium myrtillus (MIC = 8 µg/mL). The best activity against M. tuberculosis was observed for extracts of C. arbuscula , Empetrum nigrum , J. communis roots, Calluna vulgaris aerial parts, Myrica gale roots and stems (93 to 99% inhibition at 100 µg/mL). Potent antitubercular activity (90 to 96% inhibition at 100 µg/mL) was also observed for the ethanol extracts of Xerocomus badius , Chalciporus piperatus , Suillus luteus and of endophytes isolated from C. vulgaris , E. nigrum , Vaccinium vitis‐idaea and V. myrtillus . The results obtained this study provide, in part, some scientific basis for the traditional use of some of the selected plants in the treatment of tuberculosis. They also indicate that fungal endophytes recovered from Scottish plants are a source of antimycobacterial agents worthy of further investigation. Copyright © 2009 John Wiley & Sons, Ltd. Article in Journal/Newspaper Empetrum nigrum Wiley Online Library Phytotherapy Research 24 5 692 698 |
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Abstract With tuberculosis the leading bacterial killer worldwide and other mycobacterial diseases on the increase, the search for new antimycobacterial agents is timely. In this study, extracts from plants, lichens and fungal endophytes of Scottish provenance were screened for activity against Mycobacterium aurum and M. tuberculosis H 37 Rv. The best activity against M. aurum was observed for extracts of Juniperus communis roots and Cladonia arbuscula (MIC = 4 µg/mL), and a fungal endophyte isolated from Vaccinium myrtillus (MIC = 8 µg/mL). The best activity against M. tuberculosis was observed for extracts of C. arbuscula , Empetrum nigrum , J. communis roots, Calluna vulgaris aerial parts, Myrica gale roots and stems (93 to 99% inhibition at 100 µg/mL). Potent antitubercular activity (90 to 96% inhibition at 100 µg/mL) was also observed for the ethanol extracts of Xerocomus badius , Chalciporus piperatus , Suillus luteus and of endophytes isolated from C. vulgaris , E. nigrum , Vaccinium vitis‐idaea and V. myrtillus . The results obtained this study provide, in part, some scientific basis for the traditional use of some of the selected plants in the treatment of tuberculosis. They also indicate that fungal endophytes recovered from Scottish plants are a source of antimycobacterial agents worthy of further investigation. Copyright © 2009 John Wiley & Sons, Ltd. |
author2 |
EPSRC |
format |
Article in Journal/Newspaper |
author |
Gordien, Andréa Y. Gray, Alexander I. Ingleby, Kevin Franzblau, Scott G. Seidel, Véronique |
spellingShingle |
Gordien, Andréa Y. Gray, Alexander I. Ingleby, Kevin Franzblau, Scott G. Seidel, Véronique Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
author_facet |
Gordien, Andréa Y. Gray, Alexander I. Ingleby, Kevin Franzblau, Scott G. Seidel, Véronique |
author_sort |
Gordien, Andréa Y. |
title |
Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_short |
Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_full |
Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_fullStr |
Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_full_unstemmed |
Activity of Scottish Plant, Lichen and Fungal Endophyte Extracts against Mycobacterium aurum and Mycobacterium tuberculosis |
title_sort |
activity of scottish plant, lichen and fungal endophyte extracts against mycobacterium aurum and mycobacterium tuberculosis |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.1002/ptr.2988 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fptr.2988 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.2988 |
genre |
Empetrum nigrum |
genre_facet |
Empetrum nigrum |
op_source |
Phytotherapy Research volume 24, issue 5, page 692-698 ISSN 0951-418X 1099-1573 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ptr.2988 |
container_title |
Phytotherapy Research |
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24 |
container_issue |
5 |
container_start_page |
692 |
op_container_end_page |
698 |
_version_ |
1802643822343094272 |