Potentiation of warfarin toxicity to roof rats ( Rattus rattus) by L‐histidine and by vitamin K adsorbers
Abstract The efficacy of warfarin alone or with various additives was tested against roof rats ( Rattus rattus ). Warfarin alone at 50 mg kg −1 of bait killed 37% of the roof rats where‐as the additives, L ‐histidine (40 mg kg −1 of bait), activated‐clay, charcoal and carbon (10 g kg −1 of bait), te...
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crwiley:10.1002/ps.2780100306 2024-06-02T08:13:42+00:00 Potentiation of warfarin toxicity to roof rats ( Rattus rattus) by L‐histidine and by vitamin K adsorbers Rao, Muktha Bai Krishnoji 1979 http://dx.doi.org/10.1002/ps.2780100306 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fps.2780100306 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ps.2780100306 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Pesticide Science volume 10, issue 3, page 221-226 ISSN 0031-613X 1096-9063 journal-article 1979 crwiley https://doi.org/10.1002/ps.2780100306 2024-05-03T11:42:52Z Abstract The efficacy of warfarin alone or with various additives was tested against roof rats ( Rattus rattus ). Warfarin alone at 50 mg kg −1 of bait killed 37% of the roof rats where‐as the additives, L ‐histidine (40 mg kg −1 of bait), activated‐clay, charcoal and carbon (10 g kg −1 of bait), tested individually, produced no mortality. However, when warfarin wascombined with each of these additives in turn, only the L ‐histidine combination resulted in 100% mortality while the other combinations killed 88, 75 and 63% of the test rats respectively. Further trials of paired comparison tests were carried out in order to evaluate the efficacy of the warfarin/ L ‐histidine combination under different environmental conditions. All the rats succumbed to this combination in both cage and rattery conditions when there was no alternative food. Mortality decreased to 60% in cage and 70% in rattery when alternative food was provided alongside the poison bait. Rats tended to die more quickly with the L ‐histidine combination than with warfarin alone. Field trials also confirmed that this combination was effective in reducing roof rat infestations as shown by the yield of corpses, the post‐poison bait intake and post‐operational surveillance. Article in Journal/Newspaper Rattus rattus Wiley Online Library Pesticide Science 10 3 221 226 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Abstract The efficacy of warfarin alone or with various additives was tested against roof rats ( Rattus rattus ). Warfarin alone at 50 mg kg −1 of bait killed 37% of the roof rats where‐as the additives, L ‐histidine (40 mg kg −1 of bait), activated‐clay, charcoal and carbon (10 g kg −1 of bait), tested individually, produced no mortality. However, when warfarin wascombined with each of these additives in turn, only the L ‐histidine combination resulted in 100% mortality while the other combinations killed 88, 75 and 63% of the test rats respectively. Further trials of paired comparison tests were carried out in order to evaluate the efficacy of the warfarin/ L ‐histidine combination under different environmental conditions. All the rats succumbed to this combination in both cage and rattery conditions when there was no alternative food. Mortality decreased to 60% in cage and 70% in rattery when alternative food was provided alongside the poison bait. Rats tended to die more quickly with the L ‐histidine combination than with warfarin alone. Field trials also confirmed that this combination was effective in reducing roof rat infestations as shown by the yield of corpses, the post‐poison bait intake and post‐operational surveillance. |
format |
Article in Journal/Newspaper |
author |
Rao, Muktha Bai Krishnoji |
spellingShingle |
Rao, Muktha Bai Krishnoji Potentiation of warfarin toxicity to roof rats ( Rattus rattus) by L‐histidine and by vitamin K adsorbers |
author_facet |
Rao, Muktha Bai Krishnoji |
author_sort |
Rao, Muktha Bai Krishnoji |
title |
Potentiation of warfarin toxicity to roof rats ( Rattus rattus) by L‐histidine and by vitamin K adsorbers |
title_short |
Potentiation of warfarin toxicity to roof rats ( Rattus rattus) by L‐histidine and by vitamin K adsorbers |
title_full |
Potentiation of warfarin toxicity to roof rats ( Rattus rattus) by L‐histidine and by vitamin K adsorbers |
title_fullStr |
Potentiation of warfarin toxicity to roof rats ( Rattus rattus) by L‐histidine and by vitamin K adsorbers |
title_full_unstemmed |
Potentiation of warfarin toxicity to roof rats ( Rattus rattus) by L‐histidine and by vitamin K adsorbers |
title_sort |
potentiation of warfarin toxicity to roof rats ( rattus rattus) by l‐histidine and by vitamin k adsorbers |
publisher |
Wiley |
publishDate |
1979 |
url |
http://dx.doi.org/10.1002/ps.2780100306 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fps.2780100306 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ps.2780100306 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Pesticide Science volume 10, issue 3, page 221-226 ISSN 0031-613X 1096-9063 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ps.2780100306 |
container_title |
Pesticide Science |
container_volume |
10 |
container_issue |
3 |
container_start_page |
221 |
op_container_end_page |
226 |
_version_ |
1800737291609571328 |