Cyclisierungsreaktionen β,γ‐ungesättigter Kohlensäurederivate. VII. Synthese eindeutig N‐acylierter Thiazolidin‐2‐one und Oxazolidin‐2‐one

• Published in: Journal für Praktische Chemie
• Main Authors: Widera, R., Mühlstädt, M.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1982
• Subjects: Carbonic acid
• Online Access: http://dx.doi.org/10.1002/prac.19823240620; http://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fprac.19823240620; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fprac.19823240620; https://onlinelibrary.wiley.com/doi/pdf/10.1002/prac.19823240620

Cyclization Reactions of β,γ‐Unsaturated Derivatives of Carbonic Acid. VII. Synthesis of Unequivocal N‐Acylated Thiazolidine‐2‐ones and Oxazolidine‐2‐ones A new synthetic route to N‐acylated thiazolidine‐2‐ones and oxazolidine‐2‐ones is reported: The reaction of carboxylic acid chlorides with 2‐alkoxy‐2‐thiazolines ( 1, 2 ) or ‐2‐oxazolines ( 3 ) yields unequivocal N‐acylated thiazolidine‐2‐ones ( 4–6 ) or oxazolidine‐2‐ones ( 7 ). Bifunctional acid chlorides, e.g. oxalyl chloride or thiophosgene yield compounds 11 and 12 .