Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols
Abstract Linear and star shaped polyglycidols (synonym with polyglycerols) are prepared in a controlled ring opening polymerization of protected glycidols. Beside the molar mass and the polydispersity, the architecture of the polyglycidols is controlled by using mono‐ and multifunctional mono‐ and p...
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crwiley:10.1002/pola.23359 2024-06-23T07:47:51+00:00 Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols Keul, Helmut Möller, Martin 2009 http://dx.doi.org/10.1002/pola.23359 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpola.23359 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pola.23359 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Journal of Polymer Science Part A: Polymer Chemistry volume 47, issue 13, page 3209-3231 ISSN 0887-624X 1099-0518 journal-article 2009 crwiley https://doi.org/10.1002/pola.23359 2024-06-11T04:42:25Z Abstract Linear and star shaped polyglycidols (synonym with polyglycerols) are prepared in a controlled ring opening polymerization of protected glycidols. Beside the molar mass and the polydispersity, the architecture of the polyglycidols is controlled by using mono‐ and multifunctional mono‐ and polydispers initiators. Copolymers of dissimilarly protected glycidols as well as copolymers with nonfunctional oxiranes were prepared by means of anionic polymerization while copolymers of protected glycidol with tetrahydrofuran were prepared by means of cationic polymerization. Polyethers with functional groups in the side chains (functional polyethers) with special emphasis on polyglycidols (containing hydroxymethyl groups in the side chains) were used to prepare multifunctional polymers and (hetero)grafted polymer brushes via chemical and enzyme catalyzed reaction. The potential of poly(glycidol‐ graft ‐ε‐caprolactone)‐ co ‐glycidol) prepared via enzyme catalyzed grafting of polyglycidols using ε‐caprolactone as a monomer and Lipase B from Candida antarctica as a catalyst is presented. Finally, comparative degradation studies of densely and loosely grafted polyglycidols are presented and discussed. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3209–3231, 2009 Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Journal of Polymer Science Part A: Polymer Chemistry 47 13 3209 3231 |
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English |
description |
Abstract Linear and star shaped polyglycidols (synonym with polyglycerols) are prepared in a controlled ring opening polymerization of protected glycidols. Beside the molar mass and the polydispersity, the architecture of the polyglycidols is controlled by using mono‐ and multifunctional mono‐ and polydispers initiators. Copolymers of dissimilarly protected glycidols as well as copolymers with nonfunctional oxiranes were prepared by means of anionic polymerization while copolymers of protected glycidol with tetrahydrofuran were prepared by means of cationic polymerization. Polyethers with functional groups in the side chains (functional polyethers) with special emphasis on polyglycidols (containing hydroxymethyl groups in the side chains) were used to prepare multifunctional polymers and (hetero)grafted polymer brushes via chemical and enzyme catalyzed reaction. The potential of poly(glycidol‐ graft ‐ε‐caprolactone)‐ co ‐glycidol) prepared via enzyme catalyzed grafting of polyglycidols using ε‐caprolactone as a monomer and Lipase B from Candida antarctica as a catalyst is presented. Finally, comparative degradation studies of densely and loosely grafted polyglycidols are presented and discussed. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3209–3231, 2009 |
format |
Article in Journal/Newspaper |
author |
Keul, Helmut Möller, Martin |
spellingShingle |
Keul, Helmut Möller, Martin Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols |
author_facet |
Keul, Helmut Möller, Martin |
author_sort |
Keul, Helmut |
title |
Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols |
title_short |
Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols |
title_full |
Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols |
title_fullStr |
Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols |
title_full_unstemmed |
Synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols |
title_sort |
synthesis and degradation of biomedical materials based on linear and star shaped polyglycidols |
publisher |
Wiley |
publishDate |
2009 |
url |
http://dx.doi.org/10.1002/pola.23359 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpola.23359 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pola.23359 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Journal of Polymer Science Part A: Polymer Chemistry volume 47, issue 13, page 3209-3231 ISSN 0887-624X 1099-0518 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/pola.23359 |
container_title |
Journal of Polymer Science Part A: Polymer Chemistry |
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47 |
container_issue |
13 |
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3209 |
op_container_end_page |
3231 |
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1802638052480253952 |