Hearing impairment after platinum‐based chemotherapy in childhood
Abstract Background Chemotherapy is used in the treatment of children and adolescents with malignant diseases. Some of the chemotherapeutic agents are highly toxic and may cause a number of side effects. The primary objective of this study was to evaluate the long‐term effects on hearing in cancer s...
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crwiley:10.1002/pbc.22876 2024-06-02T08:09:23+00:00 Hearing impairment after platinum‐based chemotherapy in childhood Einar‐Jon, Einarsson Trausti, Oskarsson Asgeir, Haraldsson Christian, Moëll Thomas, Wiebe Måns, Magnusson Jon, Kristinsson Hannes, Petersen 2010 http://dx.doi.org/10.1002/pbc.22876 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpbc.22876 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.22876 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Pediatric Blood & Cancer volume 56, issue 4, page 631-637 ISSN 1545-5009 1545-5017 journal-article 2010 crwiley https://doi.org/10.1002/pbc.22876 2024-05-03T11:47:31Z Abstract Background Chemotherapy is used in the treatment of children and adolescents with malignant diseases. Some of the chemotherapeutic agents are highly toxic and may cause a number of side effects. The primary objective of this study was to evaluate the long‐term effects on hearing in cancer survivors who had received platinum‐based chemotherapy in childhood or adolescence. Procedure Medical records of 297 patients, who had received treatment for cancer at the Children's Hospital, Landspitali University Hospital in Iceland between 1981 and 2006, were retrospectively reviewed. Fifteen subjects fulfilled the eligibility criteria for the study and underwent an extended audiometric evaluation. Results The results showed that three of the subjects had a high frequency hearing loss. In one subject, we observed a hearing recovery just after the completion of chemotherapy, but the hearing deteriorated again some years later. Nine of the 15 subjects (60%) had tinnitus after the cancer treatment. An evaluation of subjective hearing disability and handicap (The Hearing Measurements Scale) revealed that some subjects had great difficulties with hearing in certain situations. The Hearing Measurement Scale showed that the pure‐tone audiogram findings were only partly associated with the apparent hearing difficulties. Conclusion Regular follow‐up hearing examinations, which include both pure‐tone audiogram investigations and subjective hearing disability assessments, should be performed during and after chemotherapy to identify subjects who require particular attention. This will ensure that hearing impaired individuals are provided with the most suitable listening devices, to promote good speech and social development. Pediatr Blood Cancer 2011;56:631–637. © 2010 Wiley‐Liss, Inc. Article in Journal/Newspaper Iceland Wiley Online Library Pediatric Blood & Cancer 56 4 631 637 |
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Abstract Background Chemotherapy is used in the treatment of children and adolescents with malignant diseases. Some of the chemotherapeutic agents are highly toxic and may cause a number of side effects. The primary objective of this study was to evaluate the long‐term effects on hearing in cancer survivors who had received platinum‐based chemotherapy in childhood or adolescence. Procedure Medical records of 297 patients, who had received treatment for cancer at the Children's Hospital, Landspitali University Hospital in Iceland between 1981 and 2006, were retrospectively reviewed. Fifteen subjects fulfilled the eligibility criteria for the study and underwent an extended audiometric evaluation. Results The results showed that three of the subjects had a high frequency hearing loss. In one subject, we observed a hearing recovery just after the completion of chemotherapy, but the hearing deteriorated again some years later. Nine of the 15 subjects (60%) had tinnitus after the cancer treatment. An evaluation of subjective hearing disability and handicap (The Hearing Measurements Scale) revealed that some subjects had great difficulties with hearing in certain situations. The Hearing Measurement Scale showed that the pure‐tone audiogram findings were only partly associated with the apparent hearing difficulties. Conclusion Regular follow‐up hearing examinations, which include both pure‐tone audiogram investigations and subjective hearing disability assessments, should be performed during and after chemotherapy to identify subjects who require particular attention. This will ensure that hearing impaired individuals are provided with the most suitable listening devices, to promote good speech and social development. Pediatr Blood Cancer 2011;56:631–637. © 2010 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Einar‐Jon, Einarsson Trausti, Oskarsson Asgeir, Haraldsson Christian, Moëll Thomas, Wiebe Måns, Magnusson Jon, Kristinsson Hannes, Petersen |
spellingShingle |
Einar‐Jon, Einarsson Trausti, Oskarsson Asgeir, Haraldsson Christian, Moëll Thomas, Wiebe Måns, Magnusson Jon, Kristinsson Hannes, Petersen Hearing impairment after platinum‐based chemotherapy in childhood |
author_facet |
Einar‐Jon, Einarsson Trausti, Oskarsson Asgeir, Haraldsson Christian, Moëll Thomas, Wiebe Måns, Magnusson Jon, Kristinsson Hannes, Petersen |
author_sort |
Einar‐Jon, Einarsson |
title |
Hearing impairment after platinum‐based chemotherapy in childhood |
title_short |
Hearing impairment after platinum‐based chemotherapy in childhood |
title_full |
Hearing impairment after platinum‐based chemotherapy in childhood |
title_fullStr |
Hearing impairment after platinum‐based chemotherapy in childhood |
title_full_unstemmed |
Hearing impairment after platinum‐based chemotherapy in childhood |
title_sort |
hearing impairment after platinum‐based chemotherapy in childhood |
publisher |
Wiley |
publishDate |
2010 |
url |
http://dx.doi.org/10.1002/pbc.22876 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpbc.22876 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.22876 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Pediatric Blood & Cancer volume 56, issue 4, page 631-637 ISSN 1545-5009 1545-5017 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/pbc.22876 |
container_title |
Pediatric Blood & Cancer |
container_volume |
56 |
container_issue |
4 |
container_start_page |
631 |
op_container_end_page |
637 |
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1800755100524740608 |