Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water
Hydrogels are highly biocompatible materials, and alginate is utilized for wound dressing. Contrary to traditional beliefs, alkaline conditions (ie, pH of approximately 8.5) are favorable for healing wounds. However, existing wound dressing materials are employed under neutral or weakly acidic (pH 5...
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crwiley:10.1002/pat.5027 2024-09-15T18:01:39+00:00 Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water Teshima, Ryota Kawano, Yayoi Hanawa, Takehisa Kikuchi, Akihiko Grant-in-Aid for Extracurricular Activities for the Students in Tokyo University of Science Parents Associations 2020 http://dx.doi.org/10.1002/pat.5027 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpat.5027 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pat.5027 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/pat.5027 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Polymers for Advanced Technologies volume 31, issue 12, page 3032-3038 ISSN 1042-7147 1099-1581 journal-article 2020 crwiley https://doi.org/10.1002/pat.5027 2024-07-23T04:09:56Z Hydrogels are highly biocompatible materials, and alginate is utilized for wound dressing. Contrary to traditional beliefs, alkaline conditions (ie, pH of approximately 8.5) are favorable for healing wounds. However, existing wound dressing materials are employed under neutral or weakly acidic (pH 5.5‐6.5) conditions. To address this issue, in this study, we successfully prepared alkaline calcium alginate hydrogels using carbonic acid and evaluated their physicochemical properties. Using inversion tube tests, we determined that the gelation time of the hydrogels was less than 5 minutes. Furthermore, the pH measurements demonstrated that the prepared gels were alkaline (pH of 8.38‐8.57) due to the volatilization of carbon dioxide from the hydrogel surface. Due to the short gelation time of the hydrogels, they can be prepared immediately before use under medical settings, and the pH of the hydrogels may facilitate the proliferation of fibroblasts and keratinocytes. In addition, the physicochemical properties of the prepared hydrogels were determined to be excellent with respect to transparency, the ability to absorb physiological saline, and possessing a high water content (approximately 99%). The hydrogel prepared in this study may have applications in wound dressings. Article in Journal/Newspaper Carbonic acid Wiley Online Library Polymers for Advanced Technologies 31 12 3032 3038 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Hydrogels are highly biocompatible materials, and alginate is utilized for wound dressing. Contrary to traditional beliefs, alkaline conditions (ie, pH of approximately 8.5) are favorable for healing wounds. However, existing wound dressing materials are employed under neutral or weakly acidic (pH 5.5‐6.5) conditions. To address this issue, in this study, we successfully prepared alkaline calcium alginate hydrogels using carbonic acid and evaluated their physicochemical properties. Using inversion tube tests, we determined that the gelation time of the hydrogels was less than 5 minutes. Furthermore, the pH measurements demonstrated that the prepared gels were alkaline (pH of 8.38‐8.57) due to the volatilization of carbon dioxide from the hydrogel surface. Due to the short gelation time of the hydrogels, they can be prepared immediately before use under medical settings, and the pH of the hydrogels may facilitate the proliferation of fibroblasts and keratinocytes. In addition, the physicochemical properties of the prepared hydrogels were determined to be excellent with respect to transparency, the ability to absorb physiological saline, and possessing a high water content (approximately 99%). The hydrogel prepared in this study may have applications in wound dressings. |
author2 |
Grant-in-Aid for Extracurricular Activities for the Students in Tokyo University of Science Parents Associations |
format |
Article in Journal/Newspaper |
author |
Teshima, Ryota Kawano, Yayoi Hanawa, Takehisa Kikuchi, Akihiko |
spellingShingle |
Teshima, Ryota Kawano, Yayoi Hanawa, Takehisa Kikuchi, Akihiko Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water |
author_facet |
Teshima, Ryota Kawano, Yayoi Hanawa, Takehisa Kikuchi, Akihiko |
author_sort |
Teshima, Ryota |
title |
Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water |
title_short |
Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water |
title_full |
Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water |
title_fullStr |
Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water |
title_full_unstemmed |
Preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water |
title_sort |
preparation and evaluation of physicochemical properties of novel alkaline calcium alginate hydrogels with carbonated water |
publisher |
Wiley |
publishDate |
2020 |
url |
http://dx.doi.org/10.1002/pat.5027 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpat.5027 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pat.5027 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/pat.5027 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Polymers for Advanced Technologies volume 31, issue 12, page 3032-3038 ISSN 1042-7147 1099-1581 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/pat.5027 |
container_title |
Polymers for Advanced Technologies |
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31 |
container_issue |
12 |
container_start_page |
3032 |
op_container_end_page |
3038 |
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1810438754580561920 |