Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats

• Published in: Natural Toxins
• Main Authors: Sinna, G. Abu, Al‐Zahaby, A., El‐Aal, A. Abd, El‐Baset, A. Abd, Saber, T.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1992
• Subjects: Rattus rattus
• Online Access: http://dx.doi.org/10.1002/nt.2620010210; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fnt.2620010210; https://onlinelibrary.wiley.com/doi/pdf/10.1002/nt.2620010210

Abstract Short term administration of the venoms of the snakes Naja haje, Naja nigricollis , and Cerastes vipera and of the scorpion Leiurus quinquestriatus on the mitotic index of the duodenal mucosal cells of the white rat, Rattus rattus , has been studied. All the venoms increased the number of dividing cells of the duodenal mucosa significantly. Naja haje crude venom was fractionated into three fractions. Fraction I had no effect on the mitotic index whereas fractions II and III increased it significantly. Treatment of rats with Naja haje venom fractions II and III after blocking the histamine or the serotonin receptors did not affect the stimulatory action of the two venom fractions on the mitotic index, which it increased significantly. It was suggested that the venoms of Naja haje, Naja nigricollis, Cerastes vipera , and Leiurus quinquestriatus and Naja haje venom fractions possessed a mitogenic activity. Fraction II of Naja hajevenom acted through both the muscarinic and adrenergic receptors while fraction III acted on the adrenergic ones. © 1992 Wiley‐Liss, Inc.