Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats
Abstract Short term administration of the venoms of the snakes Naja haje, Naja nigricollis , and Cerastes vipera and of the scorpion Leiurus quinquestriatus on the mitotic index of the duodenal mucosal cells of the white rat, Rattus rattus , has been studied. All the venoms increased the number of d...
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crwiley:10.1002/nt.2620010210 2024-06-02T08:13:43+00:00 Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats Sinna, G. Abu Al‐Zahaby, A. El‐Aal, A. Abd El‐Baset, A. Abd Saber, T. 1992 http://dx.doi.org/10.1002/nt.2620010210 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fnt.2620010210 https://onlinelibrary.wiley.com/doi/pdf/10.1002/nt.2620010210 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Natural Toxins volume 1, issue 2, page 111-118 ISSN 1056-9014 1522-7189 journal-article 1992 crwiley https://doi.org/10.1002/nt.2620010210 2024-05-03T11:33:25Z Abstract Short term administration of the venoms of the snakes Naja haje, Naja nigricollis , and Cerastes vipera and of the scorpion Leiurus quinquestriatus on the mitotic index of the duodenal mucosal cells of the white rat, Rattus rattus , has been studied. All the venoms increased the number of dividing cells of the duodenal mucosa significantly. Naja haje crude venom was fractionated into three fractions. Fraction I had no effect on the mitotic index whereas fractions II and III increased it significantly. Treatment of rats with Naja haje venom fractions II and III after blocking the histamine or the serotonin receptors did not affect the stimulatory action of the two venom fractions on the mitotic index, which it increased significantly. It was suggested that the venoms of Naja haje, Naja nigricollis, Cerastes vipera , and Leiurus quinquestriatus and Naja haje venom fractions possessed a mitogenic activity. Fraction II of Naja hajevenom acted through both the muscarinic and adrenergic receptors while fraction III acted on the adrenergic ones. © 1992 Wiley‐Liss, Inc. Article in Journal/Newspaper Rattus rattus Wiley Online Library Natural Toxins 1 2 111 118 |
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English |
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Abstract Short term administration of the venoms of the snakes Naja haje, Naja nigricollis , and Cerastes vipera and of the scorpion Leiurus quinquestriatus on the mitotic index of the duodenal mucosal cells of the white rat, Rattus rattus , has been studied. All the venoms increased the number of dividing cells of the duodenal mucosa significantly. Naja haje crude venom was fractionated into three fractions. Fraction I had no effect on the mitotic index whereas fractions II and III increased it significantly. Treatment of rats with Naja haje venom fractions II and III after blocking the histamine or the serotonin receptors did not affect the stimulatory action of the two venom fractions on the mitotic index, which it increased significantly. It was suggested that the venoms of Naja haje, Naja nigricollis, Cerastes vipera , and Leiurus quinquestriatus and Naja haje venom fractions possessed a mitogenic activity. Fraction II of Naja hajevenom acted through both the muscarinic and adrenergic receptors while fraction III acted on the adrenergic ones. © 1992 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Sinna, G. Abu Al‐Zahaby, A. El‐Aal, A. Abd El‐Baset, A. Abd Saber, T. |
spellingShingle |
Sinna, G. Abu Al‐Zahaby, A. El‐Aal, A. Abd El‐Baset, A. Abd Saber, T. Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats |
author_facet |
Sinna, G. Abu Al‐Zahaby, A. El‐Aal, A. Abd El‐Baset, A. Abd Saber, T. |
author_sort |
Sinna, G. Abu |
title |
Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats |
title_short |
Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats |
title_full |
Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats |
title_fullStr |
Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats |
title_full_unstemmed |
Short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats |
title_sort |
short term effects of animal venoms on the mitotic index of the duodenal mucosa of albino rats |
publisher |
Wiley |
publishDate |
1992 |
url |
http://dx.doi.org/10.1002/nt.2620010210 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fnt.2620010210 https://onlinelibrary.wiley.com/doi/pdf/10.1002/nt.2620010210 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Natural Toxins volume 1, issue 2, page 111-118 ISSN 1056-9014 1522-7189 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/nt.2620010210 |
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Natural Toxins |
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2 |
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111 |
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118 |
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1800737315345137664 |