Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins
Abstract Neuropathy with antibodies against myelin‐associated glycoproteins (MAG/SGPG‐N) and hereditary sensorimotor neuropathy type 1 (HMSN1) are characterized by chronic demyelination with little conduction block. Electrodiagnostic studies suggest that in HMSN1 conduction slowing occurs uniformly...
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crwiley:10.1002/mus.20678 2024-06-23T07:52:22+00:00 Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins Lupu, Vitalie D. Mora, Carlos A. Dambrosia, Jim Meer, Jacob Dalakas, Marinos Floeter, Mary Kay 2007 http://dx.doi.org/10.1002/mus.20678 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmus.20678 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mus.20678 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Muscle & Nerve volume 35, issue 2, page 196-202 ISSN 0148-639X 1097-4598 journal-article 2007 crwiley https://doi.org/10.1002/mus.20678 2024-06-04T06:38:15Z Abstract Neuropathy with antibodies against myelin‐associated glycoproteins (MAG/SGPG‐N) and hereditary sensorimotor neuropathy type 1 (HMSN1) are characterized by chronic demyelination with little conduction block. Electrodiagnostic studies suggest that in HMSN1 conduction slowing occurs uniformly along the nerve, whereas in MAG/SGPG‐N it is predominantly distal. Some but not all previous reports have shown that the terminal latency index (TLI) was useful to distinguish MAG/SGPG‐N from chronic idiopathic demyelinating polyneuropathy. We compared median TLI from 21 patients with MAG/SGPG‐N with those obtained from 26 patients with HMSN1, 20 with HMSN2, and 12 healthy volunteers. All patients with TLI <0.26 had MAG/SGPG‐N, and all patients with TLI ≥0.32 had HMSN1. In the remaining patients with intermediate TLI values, ulnar distal motor latency (DML) aided in differentiation between MAG/SGPG‐N and HMSN1 with an overall sensitivity of 100% and specificity of 98%. In conclusion, median TLI in combination with ulnar DML can further guide the demyelinating neuropathy evaluation toward hereditary or autoimmune causes. Muscle Nerve, 2006 Article in Journal/Newspaper DML Wiley Online Library Muscle & Nerve 35 2 196 202 |
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Abstract Neuropathy with antibodies against myelin‐associated glycoproteins (MAG/SGPG‐N) and hereditary sensorimotor neuropathy type 1 (HMSN1) are characterized by chronic demyelination with little conduction block. Electrodiagnostic studies suggest that in HMSN1 conduction slowing occurs uniformly along the nerve, whereas in MAG/SGPG‐N it is predominantly distal. Some but not all previous reports have shown that the terminal latency index (TLI) was useful to distinguish MAG/SGPG‐N from chronic idiopathic demyelinating polyneuropathy. We compared median TLI from 21 patients with MAG/SGPG‐N with those obtained from 26 patients with HMSN1, 20 with HMSN2, and 12 healthy volunteers. All patients with TLI <0.26 had MAG/SGPG‐N, and all patients with TLI ≥0.32 had HMSN1. In the remaining patients with intermediate TLI values, ulnar distal motor latency (DML) aided in differentiation between MAG/SGPG‐N and HMSN1 with an overall sensitivity of 100% and specificity of 98%. In conclusion, median TLI in combination with ulnar DML can further guide the demyelinating neuropathy evaluation toward hereditary or autoimmune causes. Muscle Nerve, 2006 |
format |
Article in Journal/Newspaper |
author |
Lupu, Vitalie D. Mora, Carlos A. Dambrosia, Jim Meer, Jacob Dalakas, Marinos Floeter, Mary Kay |
spellingShingle |
Lupu, Vitalie D. Mora, Carlos A. Dambrosia, Jim Meer, Jacob Dalakas, Marinos Floeter, Mary Kay Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins |
author_facet |
Lupu, Vitalie D. Mora, Carlos A. Dambrosia, Jim Meer, Jacob Dalakas, Marinos Floeter, Mary Kay |
author_sort |
Lupu, Vitalie D. |
title |
Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins |
title_short |
Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins |
title_full |
Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins |
title_fullStr |
Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins |
title_full_unstemmed |
Terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins |
title_sort |
terminal latency index in neuropathy with antibodies against myelin‐associated glycoproteins |
publisher |
Wiley |
publishDate |
2007 |
url |
http://dx.doi.org/10.1002/mus.20678 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmus.20678 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mus.20678 |
genre |
DML |
genre_facet |
DML |
op_source |
Muscle & Nerve volume 35, issue 2, page 196-202 ISSN 0148-639X 1097-4598 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/mus.20678 |
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35 |
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2 |
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202 |
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1802643663893823488 |