Gadolinium‐enhanced off‐resonance contrast angiography
Abstract We describe a novel physical basis and methodology for gadolinium (Gd)‐enhanced MRA, which we call “off‐resonance contrast angiography” (ORCA). Unlike standard contrast‐enhanced (CE) MR angiography (MRA), ORCA contrast depends not on T 1 but on Gd‐induced shifts in intravascular resonance f...
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crwiley:10.1002/mrm.21175 2024-06-23T07:55:57+00:00 Gadolinium‐enhanced off‐resonance contrast angiography Edelman, Robert R. Storey, Pippa Dunkle, Eugene Li, Wei Carrillo, Andres Vu, Anthony Carroll, Timothy J. 2007 http://dx.doi.org/10.1002/mrm.21175 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmrm.21175 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mrm.21175 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Magnetic Resonance in Medicine volume 57, issue 3, page 475-484 ISSN 0740-3194 1522-2594 journal-article 2007 crwiley https://doi.org/10.1002/mrm.21175 2024-06-11T04:41:48Z Abstract We describe a novel physical basis and methodology for gadolinium (Gd)‐enhanced MRA, which we call “off‐resonance contrast angiography” (ORCA). Unlike standard contrast‐enhanced (CE) MR angiography (MRA), ORCA contrast depends not on T 1 but on Gd‐induced shifts in intravascular resonance frequency due to the bulk magnetic susceptibility (BMS) effects of Gd. The method was tested at 3 Tesla in phantoms with a range of dilutions of Gd‐DTPA and ultrasmall iron oxide contrast agent (CA). With the use of ORCA, complete background suppression was obtained without image subtraction. As a result, catheters filled with various Gd dilutions proved to be highly conspicuous in ORCA projection images. This feature may make ORCA particularly attractive for passive catheter tracking during MR‐guided endovascular procedures. Gd‐induced intravascular frequency shifts were measured in human subjects and found to be in the expected range. ORCA was used to create angiograms of forearm veins that were comparable in quality to standard CE‐MRA. In addition, ORCA images of the extracranial carotid bifurcation were successfully acquired during intravenous contrast administration. However, significant technical restrictions also exist, including a dependence on vessel orientation with respect to B 0 , and sensitivity to static field inhomogeneities. Further study is needed to determine the practicality and potential clinical utility of this method. Magn Reson Med 57:475–484, 2007. © 2007 Wiley‐Liss, Inc. Article in Journal/Newspaper Orca Wiley Online Library Magnetic Resonance in Medicine 57 3 475 484 |
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Wiley Online Library |
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description |
Abstract We describe a novel physical basis and methodology for gadolinium (Gd)‐enhanced MRA, which we call “off‐resonance contrast angiography” (ORCA). Unlike standard contrast‐enhanced (CE) MR angiography (MRA), ORCA contrast depends not on T 1 but on Gd‐induced shifts in intravascular resonance frequency due to the bulk magnetic susceptibility (BMS) effects of Gd. The method was tested at 3 Tesla in phantoms with a range of dilutions of Gd‐DTPA and ultrasmall iron oxide contrast agent (CA). With the use of ORCA, complete background suppression was obtained without image subtraction. As a result, catheters filled with various Gd dilutions proved to be highly conspicuous in ORCA projection images. This feature may make ORCA particularly attractive for passive catheter tracking during MR‐guided endovascular procedures. Gd‐induced intravascular frequency shifts were measured in human subjects and found to be in the expected range. ORCA was used to create angiograms of forearm veins that were comparable in quality to standard CE‐MRA. In addition, ORCA images of the extracranial carotid bifurcation were successfully acquired during intravenous contrast administration. However, significant technical restrictions also exist, including a dependence on vessel orientation with respect to B 0 , and sensitivity to static field inhomogeneities. Further study is needed to determine the practicality and potential clinical utility of this method. Magn Reson Med 57:475–484, 2007. © 2007 Wiley‐Liss, Inc. |
format |
Article in Journal/Newspaper |
author |
Edelman, Robert R. Storey, Pippa Dunkle, Eugene Li, Wei Carrillo, Andres Vu, Anthony Carroll, Timothy J. |
spellingShingle |
Edelman, Robert R. Storey, Pippa Dunkle, Eugene Li, Wei Carrillo, Andres Vu, Anthony Carroll, Timothy J. Gadolinium‐enhanced off‐resonance contrast angiography |
author_facet |
Edelman, Robert R. Storey, Pippa Dunkle, Eugene Li, Wei Carrillo, Andres Vu, Anthony Carroll, Timothy J. |
author_sort |
Edelman, Robert R. |
title |
Gadolinium‐enhanced off‐resonance contrast angiography |
title_short |
Gadolinium‐enhanced off‐resonance contrast angiography |
title_full |
Gadolinium‐enhanced off‐resonance contrast angiography |
title_fullStr |
Gadolinium‐enhanced off‐resonance contrast angiography |
title_full_unstemmed |
Gadolinium‐enhanced off‐resonance contrast angiography |
title_sort |
gadolinium‐enhanced off‐resonance contrast angiography |
publisher |
Wiley |
publishDate |
2007 |
url |
http://dx.doi.org/10.1002/mrm.21175 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmrm.21175 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mrm.21175 |
genre |
Orca |
genre_facet |
Orca |
op_source |
Magnetic Resonance in Medicine volume 57, issue 3, page 475-484 ISSN 0740-3194 1522-2594 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/mrm.21175 |
container_title |
Magnetic Resonance in Medicine |
container_volume |
57 |
container_issue |
3 |
container_start_page |
475 |
op_container_end_page |
484 |
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1802648755246202880 |