Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska
Scope The relationship between dietary vitamin K and plasma PIVKA‐II concentration, a biomarker of hepatic vitamin K status, in a Yup'ik study population in southwestern Alaska is investigated. Methods and results A total of 659 male and female, self‐reported Yup'ik people, ≥14 years of ag...
Published in: | Molecular Nutrition & Food Research |
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Online Access: | http://dx.doi.org/10.1002/mnfr.201700746 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201700746 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201700746 |
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crwiley:10.1002/mnfr.201700746 2024-09-30T14:45:22+00:00 Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska Au, Nicholas T. Ryman, Tove Rettie, Allan E. Hopkins, Scarlett E. Boyer, Bert B. Black, Jynene Philip, Jacques Yracheta, Joseph Fohner, Alison E. Reyes, Morayma Thornton, Timothy A. Austin, Melissa A. Thummel, Kenneth E. National Institutes of Health 2017 http://dx.doi.org/10.1002/mnfr.201700746 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201700746 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201700746 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Nutrition & Food Research volume 62, issue 3 ISSN 1613-4125 1613-4133 journal-article 2017 crwiley https://doi.org/10.1002/mnfr.201700746 2024-09-11T04:13:19Z Scope The relationship between dietary vitamin K and plasma PIVKA‐II concentration, a biomarker of hepatic vitamin K status, in a Yup'ik study population in southwestern Alaska is investigated. Methods and results A total of 659 male and female, self‐reported Yup'ik people, ≥14 years of age, were enrolled. Blood is collected for genotyping and plasma PIVKA‐II biomarker analysis. A Yup'ik‐specific dietary food frequency questionnaire is used to assess vitamin K intake. Among the participants, 22% report not consuming foods rich in vitamin K during the past year and 36% have a PIVKA‐II concentration ≥ 2 ng mL –1 , indicating vitamin K insufficiency. The odds of an elevated PIVKA‐II concentration are 33% lower in individuals reporting any versus no consumption of vitamin‐K‐rich foods. The association is significant after adjusting for CYP4F2*3 genotype. Tundra greens are high in vitamin K1 content, but an exploratory analysis suggests that subsistence meat sources have a greater effect on vitamin K status. Conclusions A substantial proportion of the Yup'ik population exhibits vitamin K insufficiency, which is associated with low consumption of vitamin K rich foods and which might affect an individual's response to anticoagulant drugs such as warfarin that target the vitamin K cycle. Article in Journal/Newspaper Tundra Yup'ik Alaska Wiley Online Library Pivka ENVELOPE(41.162,41.162,62.803,62.803) Molecular Nutrition & Food Research 62 3 1700746 |
institution |
Open Polar |
collection |
Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Scope The relationship between dietary vitamin K and plasma PIVKA‐II concentration, a biomarker of hepatic vitamin K status, in a Yup'ik study population in southwestern Alaska is investigated. Methods and results A total of 659 male and female, self‐reported Yup'ik people, ≥14 years of age, were enrolled. Blood is collected for genotyping and plasma PIVKA‐II biomarker analysis. A Yup'ik‐specific dietary food frequency questionnaire is used to assess vitamin K intake. Among the participants, 22% report not consuming foods rich in vitamin K during the past year and 36% have a PIVKA‐II concentration ≥ 2 ng mL –1 , indicating vitamin K insufficiency. The odds of an elevated PIVKA‐II concentration are 33% lower in individuals reporting any versus no consumption of vitamin‐K‐rich foods. The association is significant after adjusting for CYP4F2*3 genotype. Tundra greens are high in vitamin K1 content, but an exploratory analysis suggests that subsistence meat sources have a greater effect on vitamin K status. Conclusions A substantial proportion of the Yup'ik population exhibits vitamin K insufficiency, which is associated with low consumption of vitamin K rich foods and which might affect an individual's response to anticoagulant drugs such as warfarin that target the vitamin K cycle. |
author2 |
National Institutes of Health |
format |
Article in Journal/Newspaper |
author |
Au, Nicholas T. Ryman, Tove Rettie, Allan E. Hopkins, Scarlett E. Boyer, Bert B. Black, Jynene Philip, Jacques Yracheta, Joseph Fohner, Alison E. Reyes, Morayma Thornton, Timothy A. Austin, Melissa A. Thummel, Kenneth E. |
spellingShingle |
Au, Nicholas T. Ryman, Tove Rettie, Allan E. Hopkins, Scarlett E. Boyer, Bert B. Black, Jynene Philip, Jacques Yracheta, Joseph Fohner, Alison E. Reyes, Morayma Thornton, Timothy A. Austin, Melissa A. Thummel, Kenneth E. Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska |
author_facet |
Au, Nicholas T. Ryman, Tove Rettie, Allan E. Hopkins, Scarlett E. Boyer, Bert B. Black, Jynene Philip, Jacques Yracheta, Joseph Fohner, Alison E. Reyes, Morayma Thornton, Timothy A. Austin, Melissa A. Thummel, Kenneth E. |
author_sort |
Au, Nicholas T. |
title |
Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska |
title_short |
Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska |
title_full |
Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska |
title_fullStr |
Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska |
title_full_unstemmed |
Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska |
title_sort |
dietary vitamin k and association with hepatic vitamin k status in a yup'ik study population from southwestern alaska |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1002/mnfr.201700746 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201700746 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201700746 |
long_lat |
ENVELOPE(41.162,41.162,62.803,62.803) |
geographic |
Pivka |
geographic_facet |
Pivka |
genre |
Tundra Yup'ik Alaska |
genre_facet |
Tundra Yup'ik Alaska |
op_source |
Molecular Nutrition & Food Research volume 62, issue 3 ISSN 1613-4125 1613-4133 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/mnfr.201700746 |
container_title |
Molecular Nutrition & Food Research |
container_volume |
62 |
container_issue |
3 |
container_start_page |
1700746 |
_version_ |
1811646078253006848 |