Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska
Scope The relationship between dietary vitamin K and plasma PIVKA‐II concentration, a biomarker of hepatic vitamin K status, in a Yup'ik study population in southwestern Alaska is investigated. Methods and results A total of 659 male and female, self‐reported Yup'ik people, ≥14 years of ag...
Published in: | Molecular Nutrition & Food Research |
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Main Authors: | , , , , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2017
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/mnfr.201700746 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201700746 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201700746 |
Summary: | Scope The relationship between dietary vitamin K and plasma PIVKA‐II concentration, a biomarker of hepatic vitamin K status, in a Yup'ik study population in southwestern Alaska is investigated. Methods and results A total of 659 male and female, self‐reported Yup'ik people, ≥14 years of age, were enrolled. Blood is collected for genotyping and plasma PIVKA‐II biomarker analysis. A Yup'ik‐specific dietary food frequency questionnaire is used to assess vitamin K intake. Among the participants, 22% report not consuming foods rich in vitamin K during the past year and 36% have a PIVKA‐II concentration ≥ 2 ng mL –1 , indicating vitamin K insufficiency. The odds of an elevated PIVKA‐II concentration are 33% lower in individuals reporting any versus no consumption of vitamin‐K‐rich foods. The association is significant after adjusting for CYP4F2*3 genotype. Tundra greens are high in vitamin K1 content, but an exploratory analysis suggests that subsistence meat sources have a greater effect on vitamin K status. Conclusions A substantial proportion of the Yup'ik population exhibits vitamin K insufficiency, which is associated with low consumption of vitamin K rich foods and which might affect an individual's response to anticoagulant drugs such as warfarin that target the vitamin K cycle. |
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