Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE‐Deficient Mice
Scope Antarctic krill is a great source of n‐3 fatty acids and high‐quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. Methods and results Sixty apoEKO mice were divided into four groups and fed Western diet (...
Published in: | Molecular Nutrition & Food Research |
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Online Access: | http://dx.doi.org/10.1002/mnfr.201700098 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201700098 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201700098 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mnfr.201700098 |
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crwiley:10.1002/mnfr.201700098 2024-06-23T07:47:47+00:00 Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE‐Deficient Mice Parolini, Cinzia Bjorndal, Bodil Busnelli, Marco Manzini, Stefano Ganzetti, Giulia S. Dellera, Federica Ramsvik, Marie Bruheim, Inge Berge, Rolf Kristian Chiesa, Giulia Norges Forskningsråd Universitetet i Bergen Seventh Framework Programme Fondazione Cariplo 2017 http://dx.doi.org/10.1002/mnfr.201700098 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201700098 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201700098 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mnfr.201700098 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Molecular Nutrition & Food Research volume 61, issue 12 ISSN 1613-4125 1613-4133 journal-article 2017 crwiley https://doi.org/10.1002/mnfr.201700098 2024-06-13T04:24:25Z Scope Antarctic krill is a great source of n‐3 fatty acids and high‐quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. Methods and results Sixty apoEKO mice were divided into four groups and fed Western diet (CONTROL) or Western‐like diets, differing for protein or fat content. Specifically, casein or fat in CONTROL was partially replaced by krill proteins (PRO), krill oil (KRILL OIL), or both (KRILL OIL+PRO). In KRILL OIL+PRO and KRILL OIL, cholesterol levels were significantly lower than in CONTROL group. Atherosclerosis in aorta of PRO, KRILL OIL and KRILL OIL+PRO was lower than in CONTROL, whereas, at the aortic sinus, atherosclerosis reduction was only observed in KRILL OIL. Liver steatosis, commonly present in CONTROL and PRO animals, was sporadic in KRILL OIL+PRO and KRILL OIL mice. Krill oil containing diets affected the expression of genes involved in cholesterol metabolism, mainly HMG‐CoA reductase. No reduced systemic inflammation was found in all groups. Conclusion Krill oil containing diets were able to reduce cholesterol levels, inhibit plaque development and prevent liver damage. Krill proteins also reduced atherosclerosis development through mechanisms not involving lipid metabolism. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill Wiley Online Library Antarctic Molecular Nutrition & Food Research 61 12 1700098 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Scope Antarctic krill is a great source of n‐3 fatty acids and high‐quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. Methods and results Sixty apoEKO mice were divided into four groups and fed Western diet (CONTROL) or Western‐like diets, differing for protein or fat content. Specifically, casein or fat in CONTROL was partially replaced by krill proteins (PRO), krill oil (KRILL OIL), or both (KRILL OIL+PRO). In KRILL OIL+PRO and KRILL OIL, cholesterol levels were significantly lower than in CONTROL group. Atherosclerosis in aorta of PRO, KRILL OIL and KRILL OIL+PRO was lower than in CONTROL, whereas, at the aortic sinus, atherosclerosis reduction was only observed in KRILL OIL. Liver steatosis, commonly present in CONTROL and PRO animals, was sporadic in KRILL OIL+PRO and KRILL OIL mice. Krill oil containing diets affected the expression of genes involved in cholesterol metabolism, mainly HMG‐CoA reductase. No reduced systemic inflammation was found in all groups. Conclusion Krill oil containing diets were able to reduce cholesterol levels, inhibit plaque development and prevent liver damage. Krill proteins also reduced atherosclerosis development through mechanisms not involving lipid metabolism. |
author2 |
Norges Forskningsråd Universitetet i Bergen Seventh Framework Programme Fondazione Cariplo |
format |
Article in Journal/Newspaper |
author |
Parolini, Cinzia Bjorndal, Bodil Busnelli, Marco Manzini, Stefano Ganzetti, Giulia S. Dellera, Federica Ramsvik, Marie Bruheim, Inge Berge, Rolf Kristian Chiesa, Giulia |
spellingShingle |
Parolini, Cinzia Bjorndal, Bodil Busnelli, Marco Manzini, Stefano Ganzetti, Giulia S. Dellera, Federica Ramsvik, Marie Bruheim, Inge Berge, Rolf Kristian Chiesa, Giulia Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE‐Deficient Mice |
author_facet |
Parolini, Cinzia Bjorndal, Bodil Busnelli, Marco Manzini, Stefano Ganzetti, Giulia S. Dellera, Federica Ramsvik, Marie Bruheim, Inge Berge, Rolf Kristian Chiesa, Giulia |
author_sort |
Parolini, Cinzia |
title |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE‐Deficient Mice |
title_short |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE‐Deficient Mice |
title_full |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE‐Deficient Mice |
title_fullStr |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE‐Deficient Mice |
title_full_unstemmed |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE‐Deficient Mice |
title_sort |
effect of dietary components from antarctic krill on atherosclerosis in apoe‐deficient mice |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1002/mnfr.201700098 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmnfr.201700098 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201700098 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mnfr.201700098 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_source |
Molecular Nutrition & Food Research volume 61, issue 12 ISSN 1613-4125 1613-4133 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/mnfr.201700098 |
container_title |
Molecular Nutrition & Food Research |
container_volume |
61 |
container_issue |
12 |
container_start_page |
1700098 |
_version_ |
1802637947364704256 |