Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral ( R)‐ or ( S)‐Ibuprofen Pendants
An interesting cooperation between Candida antarctica Lipase B (CAL‐B) and alkaline protease from Bacillus subtilis (BSP) in the copolymerization of bulky ibuprofen‐containing hydroxyacid methyl ester (HAEP) and ε ‐caprolactone ( ε ‐CL) is observed. This cooperation improved the of the polymers from...
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crwiley:10.1002/marc.201400394 2024-06-02T07:58:39+00:00 Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral ( R)‐ or ( S)‐Ibuprofen Pendants Qian, Xueqi Wang, Jianfeng Li, Yanyan Lin, Xianfu Wu, Qi 2014 http://dx.doi.org/10.1002/marc.201400394 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmarc.201400394 https://onlinelibrary.wiley.com/doi/pdf/10.1002/marc.201400394 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor Macromolecular Rapid Communications volume 35, issue 20, page 1788-1794 ISSN 1022-1336 1521-3927 journal-article 2014 crwiley https://doi.org/10.1002/marc.201400394 2024-05-03T10:57:37Z An interesting cooperation between Candida antarctica Lipase B (CAL‐B) and alkaline protease from Bacillus subtilis (BSP) in the copolymerization of bulky ibuprofen‐containing hydroxyacid methyl ester (HAEP) and ε ‐caprolactone ( ε ‐CL) is observed. This cooperation improved the of the polymers from 3130 (CAL‐B) to 9200 g mol –1 (CAL‐B/BSP). Experimental results clearly indicate that CAL‐B mainly catalyzes the ring‐opening polymerization (ROP) of ε ‐CL under the initiation of HAEP to form the homopolymer of ε ‐CL, while BSP catalyzes the subsequent polycondensation of the ROP product to yield the copolymer with increased molecular weight. Furthermore, using suitable chemo‐enzymatic methods, valuable polyesters with chiral ( R )‐ or ( S )‐ibuprofen pendants can be tailor‐made. image Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Macromolecular Rapid Communications 35 20 1788 1794 |
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Open Polar |
collection |
Wiley Online Library |
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crwiley |
language |
English |
description |
An interesting cooperation between Candida antarctica Lipase B (CAL‐B) and alkaline protease from Bacillus subtilis (BSP) in the copolymerization of bulky ibuprofen‐containing hydroxyacid methyl ester (HAEP) and ε ‐caprolactone ( ε ‐CL) is observed. This cooperation improved the of the polymers from 3130 (CAL‐B) to 9200 g mol –1 (CAL‐B/BSP). Experimental results clearly indicate that CAL‐B mainly catalyzes the ring‐opening polymerization (ROP) of ε ‐CL under the initiation of HAEP to form the homopolymer of ε ‐CL, while BSP catalyzes the subsequent polycondensation of the ROP product to yield the copolymer with increased molecular weight. Furthermore, using suitable chemo‐enzymatic methods, valuable polyesters with chiral ( R )‐ or ( S )‐ibuprofen pendants can be tailor‐made. image |
format |
Article in Journal/Newspaper |
author |
Qian, Xueqi Wang, Jianfeng Li, Yanyan Lin, Xianfu Wu, Qi |
spellingShingle |
Qian, Xueqi Wang, Jianfeng Li, Yanyan Lin, Xianfu Wu, Qi Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral ( R)‐ or ( S)‐Ibuprofen Pendants |
author_facet |
Qian, Xueqi Wang, Jianfeng Li, Yanyan Lin, Xianfu Wu, Qi |
author_sort |
Qian, Xueqi |
title |
Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral ( R)‐ or ( S)‐Ibuprofen Pendants |
title_short |
Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral ( R)‐ or ( S)‐Ibuprofen Pendants |
title_full |
Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral ( R)‐ or ( S)‐Ibuprofen Pendants |
title_fullStr |
Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral ( R)‐ or ( S)‐Ibuprofen Pendants |
title_full_unstemmed |
Two Enzyme Cooperatively Catalyzed Tandem Polymerization for the Synthesis of Polyester Containing Chiral ( R)‐ or ( S)‐Ibuprofen Pendants |
title_sort |
two enzyme cooperatively catalyzed tandem polymerization for the synthesis of polyester containing chiral ( r)‐ or ( s)‐ibuprofen pendants |
publisher |
Wiley |
publishDate |
2014 |
url |
http://dx.doi.org/10.1002/marc.201400394 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmarc.201400394 https://onlinelibrary.wiley.com/doi/pdf/10.1002/marc.201400394 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Macromolecular Rapid Communications volume 35, issue 20, page 1788-1794 ISSN 1022-1336 1521-3927 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/marc.201400394 |
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Macromolecular Rapid Communications |
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35 |
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20 |
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1788 |
op_container_end_page |
1794 |
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1800742078404100096 |