Improved Swelling Property of Tissue Adhesive Hydrogels Based on α‐Cyclodextrin/Decyl Group‐Modified Alaska Pollock Gelatin Inclusion Complexes

Abstract Adhesives/sealants are used after suturing to prevent leakage of cerebrospinal fluid from an anastomotic site. Commercial adhesives/sealants have been used to close the cerebral dura. However, swelling of the cured adhesives/sealants induces increased intracranial pressure and decreases the...

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Bibliographic Details
Published in:Macromolecular Bioscience
Main Authors: Komatsu, Hiyori, Watanabe, Shiharu, Ito, Shima, Nagasaka, Kazuhiro, Nishiguchi, Akihiro, Taguchi, Tetsushi
Other Authors: Japan Society for the Promotion of Science, Uehara Memorial Foundation
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2023
Subjects:
alaska pollock
Alaska
Online Access:http://dx.doi.org/10.1002/mabi.202300097
https://onlinelibrary.wiley.com/doi/pdf/10.1002/mabi.202300097
Description
Summary:Abstract Adhesives/sealants are used after suturing to prevent leakage of cerebrospinal fluid from an anastomotic site. Commercial adhesives/sealants have been used to close the cerebral dura. However, swelling of the cured adhesives/sealants induces increased intracranial pressure and decreases the strength of the seal. In the present study, tissue adhesive hydrogels with improved swelling property using inclusion complex composed of α ‐cyclodextrin ( α CD) and decyl group (C10)‐modified Alaska pollock‐derived gelatin (C10‐ApGltn) with a high degree of substitution (DS) (>20 mol%) are developed. Viscosity of C10‐ApGltn with a high DS solution remarkably decreased by the addition of α CD. The resulting α CD/C10‐ApGltn adhesive hydrogel composed of α CD/C10‐ApGltn inclusion complexes and poly(ethylene glycol) (PEG)‐based crosslinker showed improved swelling property after immersion in saline. Also, the resulting adhesive has a significantly higher burst strength than fibrin‐based adhesives and is as strong as a PEG‐based adhesive. Quantitative analysis of α CD revealed that the improved swelling property of the resulting adhesive hydrogels is induced by the release of α CD from cured adhesive, and the subsequent assembly of decyl groups in the saline. These results suggest that adhesives developed using the α CD/C10‐ApGltn inclusion complex can be useful for closing the cerebral dura mater.

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